Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review
Olesja Bondarenko,Katre Juganson,Katre Juganson,Angela Ivask,Kaja Kasemets,Monika Mortimer,Monika Mortimer,Anne Kahru +7 more
TLDR
The toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.Abstract:
Nanoparticles (NPs) of copper oxide (CuO), zinc oxide (ZnO) and especially nanosilver are intentionally used to fight the undesirable growth of bacteria, fungi and algae. Release of these NPs from consumer and household products into waste streams and further into the environment may, however, pose threat to the ‘non-target’ organisms, such as natural microbes and aquatic organisms. This review summarizes the recent research on (eco)toxicity of silver (Ag), CuO and ZnO NPs. Organism-wise it focuses on key test species used for the analysis of ecotoxicological hazard. For comparison, the toxic effects of studied NPs toward mammalian cells in vitro were addressed. Altogether 317 L(E)C50 or minimal inhibitory concentrations (MIC) values were obtained for algae, crustaceans, fish, bacteria, yeast, nematodes, protozoa and mammalian cell lines. As a rule, crustaceans, algae and fish proved most sensitive to the studied NPs. The median L(E)C50 values of Ag NPs, CuO NPs and ZnO NPs (mg/L) were 0.01, 2.1 and 2.3 for crustaceans; 0.36, 2.8 and 0.08 for algae; and 1.36, 100 and 3.0 for fish, respectively. Surprisingly, the NPs were less toxic to bacteria than to aquatic organisms: the median MIC values for bacteria were 7.1, 200 and 500 mg/L for Ag, CuO and ZnO NPs, respectively. In comparison, the respective median L(E)C50 values for mammalian cells were 11.3, 25 and 43 mg/L. Thus, the toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.read more
Citations
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Physiological and morphological responses of green microalgae Chlorella vulgaris to silver nanoparticles.
Natalí Romero,Flavia F. Visentini,Vanina E. Márquez,Liliana G. Santiago,Guillermo R. Castro,Ana María Gagneten +5 more
TL;DR: Algae cell concentration, diameter, and volume, plus total lipid, protein, and carbohydrates contents in the presence of AgNPs, were significantly altered compared to untreated cells, and this study warns about possible impacts on energy flow and aquatic food web structure, and on the transfer efficiency of energy to higher trophic levels.
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Molecular Toxicity of Metal Oxide Nanoparticles in Danio rerio
TL;DR: Gene ontology analysis of genes that were differentially expressed following exposure to all three metal oxide nanoparticles showed that the nanoparticles mainly affected nucleic Acid metabolism in the nucleus via alterations in nucleic acid binding.
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Sorption and desorption studies on silver ions from aqueous solution by coconut fiber
TL;DR: In this article, the effect of several parameters, such as initial concentration, pH, temperature, etc. on the degree of removal of Ag+ from the solution was examined, and the results obtained at the equilibrium state allowed us to fit an isotherm sorption model and to calculate the maximum sorption capacity.
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Effects of silver nitrate and silver nanoparticles on a planktonic community: general trends after short-term exposure.
Jens Boenigk,Daniela Beisser,Sonja Zimmermann,Christina Bock,Jurij Jakobi,Daniel Grabner,Lars Großmann,Sven Rahmann,Stephan Barcikowski,Bernd Sures +9 more
TL;DR: The view that ionic silver rather than silver nanoparticles are responsible for silver toxicity is supported, which highlights the strength of metatranscriptome approaches for assessing metal toxicity on aquatic communities.
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Impact of surface functionalization on the uptake mechanism and toxicity effects of silver nanoparticles in HepG2 cells
Lada Brkić Ahmed,Mirta Milić,Igor M. Pongrac,Ana Marija Marjanović,Hrvoje Mlinarić,Ivan Pavičić,Srećko Gajović,Ivana Vinković Vrček +7 more
TL;DR: The study findings contribute to the criteria that should be considered in evaluating the biocompatibility and safety of novel nanomaterials.
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