Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review
Olesja Bondarenko,Katre Juganson,Katre Juganson,Angela Ivask,Kaja Kasemets,Monika Mortimer,Monika Mortimer,Anne Kahru +7 more
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TLDR
The toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.Abstract:
Nanoparticles (NPs) of copper oxide (CuO), zinc oxide (ZnO) and especially nanosilver are intentionally used to fight the undesirable growth of bacteria, fungi and algae. Release of these NPs from consumer and household products into waste streams and further into the environment may, however, pose threat to the ‘non-target’ organisms, such as natural microbes and aquatic organisms. This review summarizes the recent research on (eco)toxicity of silver (Ag), CuO and ZnO NPs. Organism-wise it focuses on key test species used for the analysis of ecotoxicological hazard. For comparison, the toxic effects of studied NPs toward mammalian cells in vitro were addressed. Altogether 317 L(E)C50 or minimal inhibitory concentrations (MIC) values were obtained for algae, crustaceans, fish, bacteria, yeast, nematodes, protozoa and mammalian cell lines. As a rule, crustaceans, algae and fish proved most sensitive to the studied NPs. The median L(E)C50 values of Ag NPs, CuO NPs and ZnO NPs (mg/L) were 0.01, 2.1 and 2.3 for crustaceans; 0.36, 2.8 and 0.08 for algae; and 1.36, 100 and 3.0 for fish, respectively. Surprisingly, the NPs were less toxic to bacteria than to aquatic organisms: the median MIC values for bacteria were 7.1, 200 and 500 mg/L for Ag, CuO and ZnO NPs, respectively. In comparison, the respective median L(E)C50 values for mammalian cells were 11.3, 25 and 43 mg/L. Thus, the toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.read more
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Aggregation, sedimentation, and dissolution of CuO and ZnO nanoparticles in five waters.
Zhilin Liu,Chao Wang,Jun Hou,Peifang Wang,Lingzhan Miao,Bowen Lv,Yangyang Yang,Guoxiang You,Yi Xu,Mingzhi Zhang,Hanlin Ci +10 more
TL;DR: The environmental behaviors of two metallic NPs, including aggregation, sedimentation, and dissolution, were systematically evaluated in five representative waters with varying properties and indicated that the aggregation and sedimentation of NPs have a strong correlation.
Journal ArticleDOI
Ag nanoparticle–coated zirconia for antibacterial prosthesis
Risa Yamada,Kosuke Nozaki,Naohiro Horiuchi,Kimihiro Yamashita,Reina Nemoto,Hiroyuki Miura,Akiko Nagai +6 more
TL;DR: Accelerated aging test showed that the AgNP-coated surface was extremely stable, exhibiting a total silver leaching level of only 1% and confirming the effectiveness of this coating method for retaining AgNPs while exerting an antibacterial effect against oral pathogens.
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Toxicity Effect of Silver Nanoparticles on Photosynthetic Pigment Content, Growth, ROS Production and Ultrastructural Changes of Microalgae Chlorella vulgaris.
Layla J. Hazeem,Gamze Kuku,Etienne Dewailly,Christian Slomianny,Alexandre Barras,Abderrahmane Hamdi,Rabah Boukherroub,Mustafa Culha,Mohamed Bououdina +8 more
TL;DR: Silver nanoparticles exhibit antibacterial activity and are extensively used in numerous applications and were found to have a negative effect on viable cell concentration, a variable effect on chlorophyll a concentration, and increased ROS formation in the marine microalgae cells.
Journal ArticleDOI
Evaluation of metal-based antimicrobial compounds for the treatment of bacterial pathogens.
Andris Evans,Kevin Kavanagh +1 more
TL;DR: In this paper, the antibacterial activity, mode of action, and potential for systemic use of a number of metal-based antibacterial complexes are discussed and the current limitations of these compounds are highlighted to determine if metalbased agents are a potential solution for the treatment of bacterial infections, especially those resistant to conventional antibiotics.
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Physiological and transcriptomic analyses reveal CuO nanoparticle inhibition of anabolic and catabolic activities of sulfate-reducing bacterium
Zhaoyu Chen,Shu-Hong Gao,Min Jin,Shengjie Sun,Ji Lu,Ping Yang,Philip L. Bond,Zhiguo Yuan,Jianhua Guo +8 more
TL;DR: This study elucidated how the anabolic and catabolic processes of a model SRB, Desulfovibrio vulgaris Hidenborough (D. vulgaris), respond to CuO NPs and offered new insights into the bacterial-nanoparticles interaction at the transcriptional level, and advance the understanding of impacts of CuONPs on SRB in the environment.
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