Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review
Olesja Bondarenko,Katre Juganson,Katre Juganson,Angela Ivask,Kaja Kasemets,Monika Mortimer,Monika Mortimer,Anne Kahru +7 more
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TLDR
The toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.Abstract:
Nanoparticles (NPs) of copper oxide (CuO), zinc oxide (ZnO) and especially nanosilver are intentionally used to fight the undesirable growth of bacteria, fungi and algae. Release of these NPs from consumer and household products into waste streams and further into the environment may, however, pose threat to the ‘non-target’ organisms, such as natural microbes and aquatic organisms. This review summarizes the recent research on (eco)toxicity of silver (Ag), CuO and ZnO NPs. Organism-wise it focuses on key test species used for the analysis of ecotoxicological hazard. For comparison, the toxic effects of studied NPs toward mammalian cells in vitro were addressed. Altogether 317 L(E)C50 or minimal inhibitory concentrations (MIC) values were obtained for algae, crustaceans, fish, bacteria, yeast, nematodes, protozoa and mammalian cell lines. As a rule, crustaceans, algae and fish proved most sensitive to the studied NPs. The median L(E)C50 values of Ag NPs, CuO NPs and ZnO NPs (mg/L) were 0.01, 2.1 and 2.3 for crustaceans; 0.36, 2.8 and 0.08 for algae; and 1.36, 100 and 3.0 for fish, respectively. Surprisingly, the NPs were less toxic to bacteria than to aquatic organisms: the median MIC values for bacteria were 7.1, 200 and 500 mg/L for Ag, CuO and ZnO NPs, respectively. In comparison, the respective median L(E)C50 values for mammalian cells were 11.3, 25 and 43 mg/L. Thus, the toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.read more
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Bioinspired NiO Nanospheres: Exploring In Vitro Toxicity Using Bm-17 and L. rohita Liver Cells, DNA Degradation, Docking, and Proposed Vacuolization Mechanism
Prashant B. Chouke,Ajay K. Potbhare,Nitin P. Meshram,M. M. Rai,Kanhaiya M. Dadure,Karan Chaudhary,Alok R. Rai,Martín F. Desimone,Ratiram Gomaji Chaudhary,Dhanraj T. Masram +9 more
TL;DR: In this article , the authors demonstrated a novel Cleome simplicifolia-mediated green fabrication of nickel oxide nanoparticles (NiO NPs) to explore in vitro toxicity in Bm-17 and Labeo rohita liver cells.
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Efficient intracellular delivery and improved biocompatibility of colloidal silver nanoparticles towards intracellular SERS immuno-sensing
TL;DR: The TATHA2 facilitated approach efficiently delivered high payload with no toxicity, pre-requisites for intracellular applications of plasmonic metal nanoparticles (PMNPs) in sensing and therapeutics.
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Combined Effects of Test Media and Dietary Algae on the Toxicity of CuO and ZnO Nanoparticles to Freshwater Microcrustaceans Daphnia magna and Heterocypris incongruens: Food for Thought.
Marge Muna,Irina Blinova,Anne Kahru,Ivana Vinković Vrček,Barbara Pem,Kaja Orupõld,Margit Heinlaan +6 more
TL;DR: The addition of algae to D. magna test medium mitigated the toxicity of CuO and ZnO NP 4⁻11-fold when the test was conducted in natural water but not in the artificial freshwater, and to add environmental relevance to NP hazard assessment for the freshwater ecosystem.
Journal ArticleDOI
Microwave-induced catalytic degradation of a textile dye using bentonite–poly(o-toluidine) nanohybrid
Ufana Riaz,S. M. Ashraf +1 more
TL;DR: In this paper, the potential use of natural clay based organic-inorganic hybrids as eco-friendly catalysts for the degradation of Malachite Green under microwave irradiation was highlighted.
Journal ArticleDOI
Development of scalable and versatile nanomaterial libraries for nanosafety studies: polyvinylpyrrolidone (PVP) capped metal oxide nanoparticles
Sophie Marie Briffa,Iseult Lynch,Vanessa Trouillet,Michael Bruns,Dimitri Hapiuk,Jian Liu,Richard E. Palmer,Eugenia Valsami-Jones +7 more
TL;DR: In this paper, the authors developed and fully characterised one such library, which included comparable NMs with a range of core chemistries, but the same capping agent and size range, for use in future studies to test the hypothesis that the core chemistry is a primary factor in controlling toxicity.
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