Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review
Olesja Bondarenko,Katre Juganson,Katre Juganson,Angela Ivask,Kaja Kasemets,Monika Mortimer,Monika Mortimer,Anne Kahru +7 more
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TLDR
The toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.Abstract:
Nanoparticles (NPs) of copper oxide (CuO), zinc oxide (ZnO) and especially nanosilver are intentionally used to fight the undesirable growth of bacteria, fungi and algae. Release of these NPs from consumer and household products into waste streams and further into the environment may, however, pose threat to the ‘non-target’ organisms, such as natural microbes and aquatic organisms. This review summarizes the recent research on (eco)toxicity of silver (Ag), CuO and ZnO NPs. Organism-wise it focuses on key test species used for the analysis of ecotoxicological hazard. For comparison, the toxic effects of studied NPs toward mammalian cells in vitro were addressed. Altogether 317 L(E)C50 or minimal inhibitory concentrations (MIC) values were obtained for algae, crustaceans, fish, bacteria, yeast, nematodes, protozoa and mammalian cell lines. As a rule, crustaceans, algae and fish proved most sensitive to the studied NPs. The median L(E)C50 values of Ag NPs, CuO NPs and ZnO NPs (mg/L) were 0.01, 2.1 and 2.3 for crustaceans; 0.36, 2.8 and 0.08 for algae; and 1.36, 100 and 3.0 for fish, respectively. Surprisingly, the NPs were less toxic to bacteria than to aquatic organisms: the median MIC values for bacteria were 7.1, 200 and 500 mg/L for Ag, CuO and ZnO NPs, respectively. In comparison, the respective median L(E)C50 values for mammalian cells were 11.3, 25 and 43 mg/L. Thus, the toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.read more
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Study on the therapeutic index and synergistic effect of Chitosan-zinc oxide nanomicellar composites for drug-resistant bacterial biofilm inhibition.
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Book ChapterDOI
An Integrated Data-Driven Strategy for Safe-by-Design Nanoparticles: The FP7 MODERN Project
Martin Brehm,Alexander Kafka,Alexander Kafka,Markus Bamler,Ralph Kühne,Gerrit Schüürmann,Lauri Sikk,Lauri Sikk,Jaanus Burk,Peeter Burk,Tarmo Tamm,Kaido Tämm,Suman Pokhrel,Lutz Mädler,Anne Kahru,Villem Aruoja,Mariliis Sihtmäe,Janeck J. Scott-Fordsmand,Peter Sørensen,Laura Escorihuela,Carlos P. Roca,Alberto Fernández,Francesc Giralt,Robert Rallo +23 more
TL;DR: This chapter describes each of the elements of a computational framework for the evaluation of the environmental and health impacts of nanoparticles including aspects related to data generation, management and integration; development of nanodescriptors; establishment of nanostructure-activity relationships; identification of nanoparticle categories; hazard ranking and risk assessment.
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Effects of silver adsorbed on fumed silica, silver phosphate glass, bentonite organomodified with silver and titanium dioxide in aquatic indicator organisms
Daiane Tomacheski,Michele Pittol,Douglas Naue Simões,Vanda Ferreira Ribeiro,Ruth Marlene Campomanes Santana +4 more
TL;DR: TiO2 demonstrated to have a low acute toxicity against D. magna, and the shape, surface chemistry, size and carrier of three additives containing silver and one with titanium dioxide on microcrustacean survival was evaluated.
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