Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review
Olesja Bondarenko,Katre Juganson,Katre Juganson,Angela Ivask,Kaja Kasemets,Monika Mortimer,Monika Mortimer,Anne Kahru +7 more
TLDR
The toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.Abstract:
Nanoparticles (NPs) of copper oxide (CuO), zinc oxide (ZnO) and especially nanosilver are intentionally used to fight the undesirable growth of bacteria, fungi and algae. Release of these NPs from consumer and household products into waste streams and further into the environment may, however, pose threat to the ‘non-target’ organisms, such as natural microbes and aquatic organisms. This review summarizes the recent research on (eco)toxicity of silver (Ag), CuO and ZnO NPs. Organism-wise it focuses on key test species used for the analysis of ecotoxicological hazard. For comparison, the toxic effects of studied NPs toward mammalian cells in vitro were addressed. Altogether 317 L(E)C50 or minimal inhibitory concentrations (MIC) values were obtained for algae, crustaceans, fish, bacteria, yeast, nematodes, protozoa and mammalian cell lines. As a rule, crustaceans, algae and fish proved most sensitive to the studied NPs. The median L(E)C50 values of Ag NPs, CuO NPs and ZnO NPs (mg/L) were 0.01, 2.1 and 2.3 for crustaceans; 0.36, 2.8 and 0.08 for algae; and 1.36, 100 and 3.0 for fish, respectively. Surprisingly, the NPs were less toxic to bacteria than to aquatic organisms: the median MIC values for bacteria were 7.1, 200 and 500 mg/L for Ag, CuO and ZnO NPs, respectively. In comparison, the respective median L(E)C50 values for mammalian cells were 11.3, 25 and 43 mg/L. Thus, the toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.read more
Citations
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Hazard evaluation of polystyrene nanoplastic with nine bioassays did not show particle-specific acute toxicity.
Margit Heinlaan,Kaja Kasemets,Villem Aruoja,Irina Blinova,Olesja Bondarenko,Aljona Lukjanova,Alla Khosrovyan,Imbi Kurvet,Mirjam Pullerits,Mariliis Sihtmäe,Grigory Vasiliev,Heiki Vija,Anne Kahru +12 more
TL;DR: Toxicity of 'as-received' PS-NPL was not fully explainable by NaN3 but also attributable to other additives in the suspensions, e.g.surfactants and biocidal NaN 3.
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Histopathological lesions and toxicity in common carp (Cyprinus carpio L. 1758) induced by copper nanoparticles.
TL;DR: The findings of the present study demonstrate that sublethal concentration of NPs‐CuO can lead to serious tissue lesions and some clinical signs; such as skin darkening and death with open mouth as well as definite fish death.
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Shape-Dependent Surface Reactivity and Antimicrobial Activity of Nano-Cupric Oxide
Leanne M. Gilbertson,Eva Albalghiti,Zachary S. Fishman,François Perreault,Charlie Corredor,Jonathan D. Posner,Menachem Elimelech,Lisa D. Pfefferle,Julie B. Zimmerman +8 more
TL;DR: These structure-property-function (SPF) and structure- property-hazard (SPH) relationships are established for nano-cupric oxide (n-CuO) as a function of shape, including nanospheres and nanosheets, and correlations between CuO surface reactivity and bacterial toxicity are revealed.
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Tissue distribution of zinc and subtle oxidative stress effects after dietary administration of ZnO nanoparticles to rainbow trout
Mona Connolly,Marta Fernández,Estefanía Conde,Fernando Torrent,José María Navas,María Luisa Fernández-Cruz +5 more
TL;DR: High levels of Zn bioaccumulation in the gills and intestine of exposed fish following exposure to both dose levels are observed and oxidative stress responses in gills associated with such long term ZnO NPs bio Accumulation and lack of elimination are evidenced.
Journal ArticleDOI
Oxidative stress-induced toxicity of CuO nanoparticles and related toxicogenomic responses in Arabidopsis thaliana.
TL;DR: CuO NPs contributed much stronger up-regulation of oxidative stress-related genes than the corresponding Cu(2+) ions, which resulted in significantly inhibited Arabidopsis growth and higher reactive oxygen species generation in root tips.
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