Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review
Olesja Bondarenko,Katre Juganson,Katre Juganson,Angela Ivask,Kaja Kasemets,Monika Mortimer,Monika Mortimer,Anne Kahru +7 more
TLDR
The toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.Abstract:
Nanoparticles (NPs) of copper oxide (CuO), zinc oxide (ZnO) and especially nanosilver are intentionally used to fight the undesirable growth of bacteria, fungi and algae. Release of these NPs from consumer and household products into waste streams and further into the environment may, however, pose threat to the ‘non-target’ organisms, such as natural microbes and aquatic organisms. This review summarizes the recent research on (eco)toxicity of silver (Ag), CuO and ZnO NPs. Organism-wise it focuses on key test species used for the analysis of ecotoxicological hazard. For comparison, the toxic effects of studied NPs toward mammalian cells in vitro were addressed. Altogether 317 L(E)C50 or minimal inhibitory concentrations (MIC) values were obtained for algae, crustaceans, fish, bacteria, yeast, nematodes, protozoa and mammalian cell lines. As a rule, crustaceans, algae and fish proved most sensitive to the studied NPs. The median L(E)C50 values of Ag NPs, CuO NPs and ZnO NPs (mg/L) were 0.01, 2.1 and 2.3 for crustaceans; 0.36, 2.8 and 0.08 for algae; and 1.36, 100 and 3.0 for fish, respectively. Surprisingly, the NPs were less toxic to bacteria than to aquatic organisms: the median MIC values for bacteria were 7.1, 200 and 500 mg/L for Ag, CuO and ZnO NPs, respectively. In comparison, the respective median L(E)C50 values for mammalian cells were 11.3, 25 and 43 mg/L. Thus, the toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.read more
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Alteration of gene expression by zinc oxide nanoparticles or zinc sulfate in vivo and comparison with in vitro data: A harmonious case
Wei-Dong Zhang,Yong Zhao,Hongfu Zhang,Shu-Kun Wang,Zhi-Hui Hao,Jing Liu,Yu-Qing Yuan,Pengfei Zhang,Hong-Di Yang,Wei Shen,Lan Li +10 more
TL;DR: Previous findings indicating ZnO NPs promote adverse effects on organisms are supported, and precautions should be taken whenZnO NPs are used as diet additives for hens because they might cause reproductive issues.
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Exposure to sublethal concentrations of Co 3 O 4 and Mn 2 O 3 nanoparticles induced elevated metal body burden in Daphnia magna.
Margit Heinlaan,Margit Heinlaan,Marge Muna,Katre Juganson,Olena Oriekhova,Serge Stoll,Anne Kahru,Vera I. Slaveykova +7 more
TL;DR: The (sub)lethal effects of Co and Mn NPs in parallel with the respective soluble metal salts on Daphnia magna were studied to address open questions and indicate potential for trophic transfer of NPs/heavy metals and thus hazard for freshwater ecosystem.
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Green synthesis of silver nanoparticles using Nardostachys jatamansi and evaluation of its anti-biofilm effect against classical colonizers.
Meenakshi Sundaram Muthuraman,S. Nithya,V. Vinoth kumar,Lowrence Rene Christena,Vellingiri Vadivel,Nagarajan Sai Subramanian,Savarimuthu Philip Anthony +6 more
TL;DR: Interestingly, biomolecules functionalised AgNPs exhibited a remarkable antioxidant, anti-inflammatory, and anti-biofilm activities and hence biosynthesized AgNBP from N. jatamansi can be used as a promising biomaterial for biomedical applications.
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Effect of gold nanoparticles and ciprofloxacin on microbial catabolism: a community‐based approach
Kela P. Weber,Elijah J. Petersen,Sonja Bissegger,Iris Koch,Jun Zhang,Kenneth J. Reimer,Lars Rehmann,Robin M. Slawson,Raymond L. Legge,Denis M. O'Carroll +9 more
TL;DR: Under the conditions considered, the possible adverse effects of AuNPs on the catabolism of microbial communities appears to be minimal and dose−response curves were generated and exemplified how this method can be used to assess the effect of a toxicant on overall catabolic capabilities of microbial Communities.
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Effect of copper nanoparticles and ions on spermatozoa motility of sea trout (Salmo trutta m. Trutta L.).
TL;DR: The effect of Cu ion on sea trout spermatozoa motility was more harmful than that of copper nanoparticles, and various copper products had different effects on LIN, ALH, and motility duration, which can also affect fertilization.
References
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