Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review
Olesja Bondarenko,Katre Juganson,Katre Juganson,Angela Ivask,Kaja Kasemets,Monika Mortimer,Monika Mortimer,Anne Kahru +7 more
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TLDR
The toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.Abstract:
Nanoparticles (NPs) of copper oxide (CuO), zinc oxide (ZnO) and especially nanosilver are intentionally used to fight the undesirable growth of bacteria, fungi and algae. Release of these NPs from consumer and household products into waste streams and further into the environment may, however, pose threat to the ‘non-target’ organisms, such as natural microbes and aquatic organisms. This review summarizes the recent research on (eco)toxicity of silver (Ag), CuO and ZnO NPs. Organism-wise it focuses on key test species used for the analysis of ecotoxicological hazard. For comparison, the toxic effects of studied NPs toward mammalian cells in vitro were addressed. Altogether 317 L(E)C50 or minimal inhibitory concentrations (MIC) values were obtained for algae, crustaceans, fish, bacteria, yeast, nematodes, protozoa and mammalian cell lines. As a rule, crustaceans, algae and fish proved most sensitive to the studied NPs. The median L(E)C50 values of Ag NPs, CuO NPs and ZnO NPs (mg/L) were 0.01, 2.1 and 2.3 for crustaceans; 0.36, 2.8 and 0.08 for algae; and 1.36, 100 and 3.0 for fish, respectively. Surprisingly, the NPs were less toxic to bacteria than to aquatic organisms: the median MIC values for bacteria were 7.1, 200 and 500 mg/L for Ag, CuO and ZnO NPs, respectively. In comparison, the respective median L(E)C50 values for mammalian cells were 11.3, 25 and 43 mg/L. Thus, the toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.read more
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A Bi2S3@mSiO2@Ag nanocomposite for enhanced CT visualization and antibacterial response in the gastrointestinal tract
TL;DR: A dual-functional Bi2S3@mSiO2@Ag nanocomposite is constructed for simultaneous enhanced X-ray computed tomography imaging and efficient antibacterial activity in the GI tract and the investigation of the long-term toxicity and biodistribution after oral administration confirms its safety at the tested dosage.
Journal ArticleDOI
Exposure to CuO Nanoparticles Mediates NFκB Activation and Enhances Amyloid Precursor Protein Expression.
Xiaoyang Mou,Alexander Pilozzi,Breeya A Tailor,Jing Yi,Catherine M. Cahill,Jack T. Rogers,Xudong Huang +6 more
TL;DR: A low dose of CuONPs effectively activated the NFκB signaling pathway and increased APP expression and the inhibition of p65 expression using siRNA abolished CuONP-mediated APP expression, suggesting thatNFκB-regulated APP expression in response to CuONp exposure may be associated with AD pathology.
Journal ArticleDOI
Metatranscriptomic Insights Into the Response of River Biofilm Communities to Ionic and Nano-Zinc Oxide Exposures.
Jordyn Bergsveinson,Julie Roy,Christine Maynard,Sylvie Sanschagrin,Claire N. Freeman,George D. W. Swerhone,James J. Dynes,Julien Tremblay,Charles W. Greer,Darren R. Korber,John R. Lawrence +10 more
TL;DR: While the physical coating of ZnO-NP may not induce specific toxicity observable at a community level, alteration of ecologically important processes of photosynthesis and nitrogen cycling are an important potential consequence of exposure to ionic Zn and Zn oxides.
Journal ArticleDOI
Comparison of Antifungal Properties of Acrylic Resin Reinforced with ZnO and Ag Nanoparticles
Mahmoud Robati Anaraki,Arash Jangjoo,Fatemeh Alimoradi,Solmaz Maleki Dizaj,Farzaneh Lotfipour +4 more
TL;DR: Evaluation of the antifungal effects of ZnO NPs in acrylic resin (polymethyle methacrylate (PMMA) as a more biocompatible material on C. albicans suggested this technique as a reliable method and determination of technical particle should be evaluated in clinical trials.
Journal ArticleDOI
Behavior of silver nanoparticles in wastewater: systematic investigation on the combined effects of surfactants and electrolytes in model systems
Ivona Capjak,Maja Zebić Avdičević,Maja Dutour Sikirić,Darija Jurašin,Amela Amela Hozić,Damir Pajić,Slaven Dobrović,Walter Goessler,Ivana Vinković Vrček +8 more
TL;DR: In this article, the authors investigated the aggregation and dissolution behavior of engineered silver nanoparticles in model aquatic systems including a range of different pH values, different concentrations of mono-and divalent electrolytes, and the presence of non-ionic, anionic and cationic surfactants used in commercial detergents.
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