Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review
Olesja Bondarenko,Katre Juganson,Katre Juganson,Angela Ivask,Kaja Kasemets,Monika Mortimer,Monika Mortimer,Anne Kahru +7 more
Reads0
Chats0
TLDR
The toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.Abstract:
Nanoparticles (NPs) of copper oxide (CuO), zinc oxide (ZnO) and especially nanosilver are intentionally used to fight the undesirable growth of bacteria, fungi and algae. Release of these NPs from consumer and household products into waste streams and further into the environment may, however, pose threat to the ‘non-target’ organisms, such as natural microbes and aquatic organisms. This review summarizes the recent research on (eco)toxicity of silver (Ag), CuO and ZnO NPs. Organism-wise it focuses on key test species used for the analysis of ecotoxicological hazard. For comparison, the toxic effects of studied NPs toward mammalian cells in vitro were addressed. Altogether 317 L(E)C50 or minimal inhibitory concentrations (MIC) values were obtained for algae, crustaceans, fish, bacteria, yeast, nematodes, protozoa and mammalian cell lines. As a rule, crustaceans, algae and fish proved most sensitive to the studied NPs. The median L(E)C50 values of Ag NPs, CuO NPs and ZnO NPs (mg/L) were 0.01, 2.1 and 2.3 for crustaceans; 0.36, 2.8 and 0.08 for algae; and 1.36, 100 and 3.0 for fish, respectively. Surprisingly, the NPs were less toxic to bacteria than to aquatic organisms: the median MIC values for bacteria were 7.1, 200 and 500 mg/L for Ag, CuO and ZnO NPs, respectively. In comparison, the respective median L(E)C50 values for mammalian cells were 11.3, 25 and 43 mg/L. Thus, the toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.read more
Citations
More filters
Journal ArticleDOI
Recent developments in paper-based microfluidic devices.
Journal ArticleDOI
SERS Nanoparticles in Medicine: From Label-Free Detection to Spectroscopic Tagging.
TL;DR: Spectroscopic Tagging helps clarify the role of X-ray diffraction in the determination of Higgs boson levels in the response of EMTs to injury.
Journal ArticleDOI
Metal-based nanoparticles as antimicrobial agents: an overview.
Elena Sánchez-López,Elena Sánchez-López,Daniela Gomes,Gerard Esteruelas,Lorena Bonilla,Ana López-Machado,Ana López-Machado,Ruth Galindo,Amanda Cano,Amanda Cano,Marta Espina,Miren Ettcheto,Miren Ettcheto,Antoni Camins,Antoni Camins,Amélia M. Silva,Alessandra Durazzo,Antonello Santini,Maria Luisa García,Maria Luisa García,Eliana B. Souto,Eliana B. Souto +21 more
TL;DR: Their added-value in the development of alternative, more effective antibiotics against multi-resistant Gram-negative bacteria has been highlighted and their production methods, physicochemical characterization, and pharmacokinetics are reviewed.
Journal ArticleDOI
Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles.
TL;DR: The degradability and clearance timelines of various siliceous nanomaterials are compared and it is highlighted that researchers can select a specific nanommaterial in this large family according to the targeted applications and the required clearance kinetics.
Journal ArticleDOI
Size-Dependent Toxicity of Silver Nanoparticles to Bacteria, Yeast, Algae, Crustaceans and Mammalian Cells In Vitro
Angela Ivask,Imbi Kurvet,Kaja Kasemets,Irina Blinova,Villem Aruoja,Sandra Suppi,Heiki Vija,Aleksandr Kakinen,Tiina Titma,Margit Heinlaan,Meeri Visnapuu,Dagmar Koller,Vambola Kisand,Anne Kahru +13 more
TL;DR: This study investigated the size-dependent toxic effects of a well-characterized library of Ag NPs to several microbial species, protozoans, algae, crustaceans and mammalian cells in vitro and showed that the toxicity of 20–80 nm Ag NPS could fully be explained by released Ag ions whereas 10 nm AgNPs proved more toxic than predicted.
References
More filters
Journal ArticleDOI
Sublethal and lethal toxicity in juvenile Senegal sole (Solea senegalensis) exposed to copper: a preliminary toxicity range-finding test.
TL;DR: The results of the study indicate the sensitivity of juvenile S. senegalensis to copper (II), the persistence of sub lethal effects and histology as a tool capable of revealing the sublethal effects of heavy metals on the environment and aquatic biota.
Journal ArticleDOI
Knock down of Caenorhabditis elegans cutc-1 Exacerbates the Sensitivity Toward High Levels of Copper
Sara Calafato,Suresh C. Swain,Samantha Jane Hughes,Samantha Jane Hughes,Peter Kille,Stephen R. Stürzenbaum +5 more
TL;DR: RNAi of cutc-1 affected brood size, growth, and induced a marked increase in protruding vulva and bagging phenotypes at higher copper exposures, indicating that cut c-1 plays a crucial role in the protection from excess copper.
Journal ArticleDOI
Microscopic and Spectroscopic Methods Applied to the Measurements of Nanoparticles in the Environment
Susmita Bandyopadhyay,Jose R. Peralta-Videa,Jose A. Hernandez-Viezcas,Milka O. Montes,Arturo A. Keller,Jorge L. Gardea-Torresdey +5 more
TL;DR: A review of the most recent literature about the methods applied to the measurement of NPs and ENPs can be found in this paper, where the authors also discuss the potential impacts of ENPs on aquatic and terrestrial ecosystems.
Book ChapterDOI
Metal-Containing Nano-Antimicrobials: Differentiating the Impact of Solubilized Metals and Particles
TL;DR: In this article, the authors discuss the recent findings on the antimicrobial mechanisms of metal-based nanomaterials with special emphasis on metal dissolution and discuss the (bio)analytical methods that have been developed and/or applied to discriminate between the toxic effects mediated by metal dissolution.
Journal ArticleDOI
Extracellular conversion of silver ions into silver nanoparticles by protozoan Tetrahymena thermophila
TL;DR: Protein analysis indicated an extensive extracellular protein binding by the Ag NPs formed in the protozoan exudates, suggesting their ability to sequester silver ions into a less bioavailable and less toxic form of silver (e.g. NPs) may be one of the adaption mechanisms of ciliate survival in contaminated environments.