Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review
Olesja Bondarenko,Katre Juganson,Katre Juganson,Angela Ivask,Kaja Kasemets,Monika Mortimer,Monika Mortimer,Anne Kahru +7 more
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TLDR
The toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.Abstract:
Nanoparticles (NPs) of copper oxide (CuO), zinc oxide (ZnO) and especially nanosilver are intentionally used to fight the undesirable growth of bacteria, fungi and algae. Release of these NPs from consumer and household products into waste streams and further into the environment may, however, pose threat to the ‘non-target’ organisms, such as natural microbes and aquatic organisms. This review summarizes the recent research on (eco)toxicity of silver (Ag), CuO and ZnO NPs. Organism-wise it focuses on key test species used for the analysis of ecotoxicological hazard. For comparison, the toxic effects of studied NPs toward mammalian cells in vitro were addressed. Altogether 317 L(E)C50 or minimal inhibitory concentrations (MIC) values were obtained for algae, crustaceans, fish, bacteria, yeast, nematodes, protozoa and mammalian cell lines. As a rule, crustaceans, algae and fish proved most sensitive to the studied NPs. The median L(E)C50 values of Ag NPs, CuO NPs and ZnO NPs (mg/L) were 0.01, 2.1 and 2.3 for crustaceans; 0.36, 2.8 and 0.08 for algae; and 1.36, 100 and 3.0 for fish, respectively. Surprisingly, the NPs were less toxic to bacteria than to aquatic organisms: the median MIC values for bacteria were 7.1, 200 and 500 mg/L for Ag, CuO and ZnO NPs, respectively. In comparison, the respective median L(E)C50 values for mammalian cells were 11.3, 25 and 43 mg/L. Thus, the toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.read more
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Comparative cytotoxicity and apoptotic pathways induced by nanosilver in human liver HepG2 and L02 cells.
TL;DR: Results suggest that apoptosis induced by nanosilver in HepG2 cells is mediated via a mitochondria-dependent pathway and the Fas death receptor pathway, which provides toxicological and mechanistic information that can help in assessing the effects of nanossilver in biological systems, including the potential for anticancer activities.
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Long-term effects of cupric oxide nanoparticles (CuO NPs) on the performance, microbial community and enzymatic activity of activated sludge in a sequencing batch reactor.
Sen Wang,Zhiwei Li,Mengchun Gao,Zonglian She,Bingrui Ma,Liang Guo,Dong Zheng,Yangguo Zhao,Chunji Jin,Xuejiao Wang,Feng Gao +10 more
TL;DR: The variations of ROS production and LDH release demonstrated that CuO NPs could induce the toxicity towards the microorganisms and destroy the integrity of microbial cytomembrane in the activated sludge.
Journal ArticleDOI
Uptake and toxicity of CuO nanoparticles to Daphnia magna varies between indirect dietary and direct waterborne exposures.
TL;DR: Examining the uptake and trophic transfer of CuO NPs from the algae Chlorella vulgaris to the crustacean Daphnia magna and assessed bio-partitioning and resulting toxicity highlighted the importance of evaluating potential ecological impacts of nanomaterials in more relevant, complex exposure scenarios.
Dissertation
Design and physico-chemical characterization of metal-containing nanoparticles for antimicrobial coatings
Journal ArticleDOI
Response of Aerobic Granular Sludge to the Long-Term Presence of CuO NPs in A/O/A SBRs: Nitrogen and Phosphorus Removal, Enzymatic Activity, and the Microbial Community
TL;DR: High-throughput sequencing showed that CuO NPs increased the abundance of nitrogen-removal bacteria and reduction of phosphorus- Removal bacteria, which is consistent with the results of pollutant removal upon long-term exposure to CuONPs.
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Silver as Antibacterial Agent: Ion, Nanoparticle, and Metal
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