Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review
Olesja Bondarenko,Katre Juganson,Katre Juganson,Angela Ivask,Kaja Kasemets,Monika Mortimer,Monika Mortimer,Anne Kahru +7 more
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The toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.Abstract:
Nanoparticles (NPs) of copper oxide (CuO), zinc oxide (ZnO) and especially nanosilver are intentionally used to fight the undesirable growth of bacteria, fungi and algae. Release of these NPs from consumer and household products into waste streams and further into the environment may, however, pose threat to the ‘non-target’ organisms, such as natural microbes and aquatic organisms. This review summarizes the recent research on (eco)toxicity of silver (Ag), CuO and ZnO NPs. Organism-wise it focuses on key test species used for the analysis of ecotoxicological hazard. For comparison, the toxic effects of studied NPs toward mammalian cells in vitro were addressed. Altogether 317 L(E)C50 or minimal inhibitory concentrations (MIC) values were obtained for algae, crustaceans, fish, bacteria, yeast, nematodes, protozoa and mammalian cell lines. As a rule, crustaceans, algae and fish proved most sensitive to the studied NPs. The median L(E)C50 values of Ag NPs, CuO NPs and ZnO NPs (mg/L) were 0.01, 2.1 and 2.3 for crustaceans; 0.36, 2.8 and 0.08 for algae; and 1.36, 100 and 3.0 for fish, respectively. Surprisingly, the NPs were less toxic to bacteria than to aquatic organisms: the median MIC values for bacteria were 7.1, 200 and 500 mg/L for Ag, CuO and ZnO NPs, respectively. In comparison, the respective median L(E)C50 values for mammalian cells were 11.3, 25 and 43 mg/L. Thus, the toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.read more
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Book ChapterDOI
Toxicity and Risk Assessment of Nanomaterials
Gulzar Ahmed Rather,Mir Zahoor Gul,Muzafar Riyaz,Arghya Chakravorty,Mohd Hashim Khan,Anima Nanda,Mohd Yasin Bhat +6 more
TL;DR: The development and advancement of nanotechnology has led to widespread use of nanomaterials (NMs) in a wide variety of fields, including the environment, agriculture, biomedicine, industry, and human health.
Additional file 1: Table S1. of Comparative toxicity and biodistribution assessments in rats following subchronic oral exposure to copper nanoparticles and microparticles
In-Chul Lee,Je-Won Ko,Sung-Hyeuk Park,Na-Rae Shin,In-Sik Shin,Changjong Moon,Je-Hein Kim,Hyoung-Chin Kim,Jong-Choon Kim +8 more
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Journal ArticleDOI
Effects of electrical biostimulation and silver ions on porcine fibroblast cells.
TL;DR: In this paper, the authors investigated transcriptomic changes in porcine fibroblast cells in response to electrical biostimulation in the presence of silver ions, and found that 2.00 mg/L of electrically generated silver ion caused an increase of ATP generation and an increase in the total pool of NAD+ and NADH, while ROS production did not change.
Journal ArticleDOI
Preparation of metal nanoparticles by femtosecond laser ablation
TL;DR: In this article, an apparatus for fabrication of metal nanoparticles (NPs) directly in liquids initiated by femtosecond laser pulses was designed and created, and the laser parameters leading to ~10 μJ/pulse energy and 0.1 GW peak power resulted in predominantly spherical particles with the sizes varying from <10 nm to ~100 nm.
DissertationDOI
Breast cancer targeted therapy using ZnO nanostructures
TL;DR: The author’s decision to publish the book was based on a review of the evidence and the book proved to be “generally satisfactory”.
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