Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review
Olesja Bondarenko,Katre Juganson,Katre Juganson,Angela Ivask,Kaja Kasemets,Monika Mortimer,Monika Mortimer,Anne Kahru +7 more
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TLDR
The toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.Abstract:
Nanoparticles (NPs) of copper oxide (CuO), zinc oxide (ZnO) and especially nanosilver are intentionally used to fight the undesirable growth of bacteria, fungi and algae. Release of these NPs from consumer and household products into waste streams and further into the environment may, however, pose threat to the ‘non-target’ organisms, such as natural microbes and aquatic organisms. This review summarizes the recent research on (eco)toxicity of silver (Ag), CuO and ZnO NPs. Organism-wise it focuses on key test species used for the analysis of ecotoxicological hazard. For comparison, the toxic effects of studied NPs toward mammalian cells in vitro were addressed. Altogether 317 L(E)C50 or minimal inhibitory concentrations (MIC) values were obtained for algae, crustaceans, fish, bacteria, yeast, nematodes, protozoa and mammalian cell lines. As a rule, crustaceans, algae and fish proved most sensitive to the studied NPs. The median L(E)C50 values of Ag NPs, CuO NPs and ZnO NPs (mg/L) were 0.01, 2.1 and 2.3 for crustaceans; 0.36, 2.8 and 0.08 for algae; and 1.36, 100 and 3.0 for fish, respectively. Surprisingly, the NPs were less toxic to bacteria than to aquatic organisms: the median MIC values for bacteria were 7.1, 200 and 500 mg/L for Ag, CuO and ZnO NPs, respectively. In comparison, the respective median L(E)C50 values for mammalian cells were 11.3, 25 and 43 mg/L. Thus, the toxic range of all the three metal-containing NPs to target- and non-target organisms overlaps, indicating that the leaching of biocidal NPs from consumer products should be addressed.read more
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A novel method for comparison of biocidal properties of nanomaterials to bacteria, yeasts and algae
Sandra Suppi,Sandra Suppi,Kaja Kasemets,Angela Ivask,Kai Künnis-Beres,Mariliis Sihtmäe,Imbi Kurvet,Villem Aruoja,Anne Kahru +8 more
TL;DR: Toxicity mechanism of biocidal chemicals seems to be similar, whatever the organism (bacteria, yeast, alga), when the organisms are not 'protected' by their environment that usually includes various organic and inorganic supplements their tolerance to toxicants is chemical- rather than organism-dependent.
Journal ArticleDOI
A One Health approach to managing the applications and implications of nanotechnologies in agriculture.
TL;DR: This Perspective outlines the need for a combined approach to regulate health and environmental risks under the same framework and proposes that a transdisciplinary approach, underpinned by the One Health concept, is needed to support the sustainable development of these technologies.
Journal ArticleDOI
Metal-based nanoparticles for bone tissue engineering.
Reza Eivazzadeh-Keihan,Ehsan Bahojb Noruzi,Ehsan Bahojb Noruzi,Karim Khanmohammadi Chenab,Amir Jafari,Fateme Radinekiyan,Seyed Masoud Hashemi,Farnoush Ahmadpour,Ali Behboudi,Jafar Mosafer,Ahad Mokhtarzadeh,Ali Maleki,Michael R. Hamblin,Michael R. Hamblin +13 more
TL;DR: The unique physiochemical properties of metal nanoparticles suggest that they can perform as novel types of scaffolds for bone tissue engineering, and the basic principles of various nanoparticle‐based composites and scaffolds are discussed.
Journal ArticleDOI
Integration of Cotton Fabrics with Biosynthesized CuO Nanoparticles for Bactericidal Activity in the Terms of Their Cytotoxicity Assessment
TL;DR: Green biosynthesis of highly active materials for healthcare and hygiene products, such as medical textiles that allow us to wear comfortable clothes with potent protection elements, is in great demand.
Journal ArticleDOI
Potential of Hyperspectral Imaging Microscopy for Semi-quantitative Analysis of Nanoparticle Uptake by Protozoa
Monika Mortimer,Monika Mortimer,Alexander Gogos,Nora Bartolomé,Anne Kahru,Thomas D. Bucheli,Vera I. Slaveykova +6 more
TL;DR: The capability of HSI-M for examining cellular uptake of different metal-based NPs, including nanosized metals, metal oxides, and CdSe/ZnS core/shell quantum dots at subtoxic concentrations is determined.
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