Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics
TLDR
This review highlights the use of trace elements in CaP biomaterials, and offers an insight into the mechanisms of how metal ions can enhance both osteogenesis and angiogenesis.About:
This article is published in Trends in Biotechnology.The article was published on 2013-10-01 and is currently open access. It has received 387 citations till now.read more
Citations
More filters
Journal ArticleDOI
Zinc and Strontium based Phosphate glass beads: a novel material for bone tissue engineering
Mustafa Alqaysi,Alaa Aldaadaa,Nicky Mordan,Rishma Shah,Jonathan C. Knowles,Jonathan C. Knowles +5 more
TL;DR: Degradable phosphate-based glasses that contain strontium, zinc and calcium were investigated to examine their function as an osteoconductive material and cellular studies emphasised that all formulations enhanced cellular proliferation.
Journal ArticleDOI
Multiphase zinc and magnesium mono-substituted calcium phosphates derived from cuttlefish bone: A multifunctional biomaterials
Antonia Ressler,Tomislav Ivanković,Irena Ivanišević,Matija Cvetnić,Maja Antunović,Inga Urlić,Hrvoje Ivanković,Marica Ivanković +7 more
TL;DR: In this article , a mixture of carbonated hydroxyapatite (HAp), octacalcium phosphate (OCP), and amorphous calcium phosphate (ACP), mono-substituted with zinc (Zn2+) and magnesium (Mg2+) ions were prepared from cuttlefish bone by wet precipitation method.
Journal ArticleDOI
Synergistic Effect of Micro-Nano-Hybrid Surfaces and Sr Doping on the Osteogenic and Angiogenic Capacity of Hydroxyapatite Bioceramics Scaffolds
TL;DR: In this paper , the synergistic effect of chemical element doping and surface modification is considered to regulate cell biological responses and improve the osteoinductive ability of biomaterials, which can be a promising material for bone defect repair.
Book ChapterDOI
The Evolution, Control, and Effects of the Compositions of Bioactive Glasses on Their Properties and Applications
TL;DR: This chapter provides an overview of new tissue engineering approaches based on therapeutic ion release, which aids in understanding how the chemical composition can be tailored according to each application.
Journal ArticleDOI
High throughput synthesis and screening of zinc-doped biphasic calcium phosphate for bone regeneration
TL;DR: In this article, a biphasic calcium phosphate (BCP) was used as the doping matrix and zinc was chosen as a doping element, and the results showed that zinc tended to enter the β-TCP structure by substituting calcium at the Ca(5) and Ca(4) sites.
References
More filters
Journal ArticleDOI
Copper toxicity, oxidative stress, and antioxidant nutrients.
Lisa M. Gaetke,Ching Kuang Chow +1 more
TL;DR: Results obtained from available animal studies suggest that the compound is protective, and further studies are needed to better understand the cellular effects of this essential, but potentially toxic, trace mineral and its functional interaction with other nutrients.
Journal ArticleDOI
WNT signaling in bone homeostasis and disease: from human mutations to treatments
Roland Baron,Michaela Kneissel +1 more
TL;DR: Current understanding of the mechanisms by which WNT signalng regulates bone homeostasis is reviewed, finding the pathway is now the target for therapeutic intervention to restore bone strength in millions of patients at risk for fracture.
Journal ArticleDOI
The Effects of Strontium Ranelate on the Risk of Vertebral Fracture in Women with Postmenopausal Osteoporosis
Pierre J. Meunier,Christian Roux,Ego Seeman,Sergio Ortolani,J. Badurski,Tim D. Spector,J. Cannata,Adam Balogh,EM Lemmel,S. Pors-Nielsen,René Rizzoli,Harry K. Genant,Jean-Yves Reginster +12 more
TL;DR: Treatment of postmenopausal osteoporosis with strontium ranelate leads to early and sustained reductions in the risk of vertebral fractures.
Journal ArticleDOI
Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis.
TL;DR: It is suggested that the stimulatory effect of the ionic products of Bioglass 45S5 dissolution on osteoblast proliferation may be mediated by IGF-II.
Journal ArticleDOI
Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review
Susmita Bose,Solaiman Tarafder +1 more
TL;DR: This review highlights some of the current drug and growth factor delivery approaches and critical issues using CaP particles, coatings, cements, and scaffolds towards orthopedic and dental applications.