Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics
TLDR
This review highlights the use of trace elements in CaP biomaterials, and offers an insight into the mechanisms of how metal ions can enhance both osteogenesis and angiogenesis.About:
This article is published in Trends in Biotechnology.The article was published on 2013-10-01 and is currently open access. It has received 387 citations till now.read more
Citations
More filters
Book ChapterDOI
Angiogenic Attributes of Multifaceted Bioactive Glass: Its Therapeutic Potential on Soft Tissues and Drug Delivery Utilization
TL;DR: This work has shown that the development of new blood vessels is angiogenesis, which is a continuous process all through life, both when the body is healthy and diseased, and suggested that treatments can be formulated by controlling itsAngiogenesis.
Journal ArticleDOI
eIF2α-ATF4 Pathway Activated by a Change in the Calcium Environment Participates in BCP-Mediated Bone Regeneration.
TL;DR: In this paper, a rat lateral femoral epicondyle defect model in vivo and a simulated BCP-mediated calcium environment in vitro were constructed for the analysis of BCPrelated osteogenesis and the activation of ERs and the eIF2α-ATF4 pathway.
Journal ArticleDOI
Biphasic calcium phosphate doped with zirconia nanoparticles for reconstruction of induced mandibular defects in dogs: cone-beam computed tomographic and histopathologic evaluation
TL;DR: In this paper , the authors evaluated osteogenic potential and biocompatibility of combining biphasic calcium phosphate with zirconia nanoparticles (4Zr TCP/HA) compared to TCP/HHA for reconstruction of induced mandibular defects in dog model.
Journal ArticleDOI
Mg‐CS/HA Microscaffolds Display Excellent Biodegradability and Controlled Release of Si and Mg Bioactive Ions to Synergistically Promote Vascularized Bone Regeneration
Ling Wei,Zhiyun Du,Chenguang Zhang,Ying-Hua Zhou,Fangyu Zhu,Huan Zhao,Feng Zhang,Pengrui Dang,Yijun Wang,Yanze Meng,Boon Chin Heng,Hongcheng Zhang,Jinlin Song,Wenwen Liu,Qing Cai,Xuliang Deng +15 more
TL;DR: In this article , a magnesium ion-doped calcium silicate/HA composite microscaffold (Mg•CS/HA) is fabricated to enhance angiogenesis and osteogenic efficiency for bone repair.
Book ChapterDOI
Osteogenic trace element doped ceramic coating for bioimplant applications
TL;DR: The main aim of biomaterials and tissue engineering is to develop biocompatible materials to replace damaged tissues as discussed by the authors , which can be fabricated from a range of different materials depending on the function for which they have been chosen to perform.
References
More filters
Journal ArticleDOI
Copper toxicity, oxidative stress, and antioxidant nutrients.
Lisa M. Gaetke,Ching Kuang Chow +1 more
TL;DR: Results obtained from available animal studies suggest that the compound is protective, and further studies are needed to better understand the cellular effects of this essential, but potentially toxic, trace mineral and its functional interaction with other nutrients.
Journal ArticleDOI
WNT signaling in bone homeostasis and disease: from human mutations to treatments
Roland Baron,Michaela Kneissel +1 more
TL;DR: Current understanding of the mechanisms by which WNT signalng regulates bone homeostasis is reviewed, finding the pathway is now the target for therapeutic intervention to restore bone strength in millions of patients at risk for fracture.
Journal ArticleDOI
The Effects of Strontium Ranelate on the Risk of Vertebral Fracture in Women with Postmenopausal Osteoporosis
Pierre J. Meunier,Christian Roux,Ego Seeman,Sergio Ortolani,J. Badurski,Tim D. Spector,J. Cannata,Adam Balogh,EM Lemmel,S. Pors-Nielsen,René Rizzoli,Harry K. Genant,Jean-Yves Reginster +12 more
TL;DR: Treatment of postmenopausal osteoporosis with strontium ranelate leads to early and sustained reductions in the risk of vertebral fractures.
Journal ArticleDOI
Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis.
TL;DR: It is suggested that the stimulatory effect of the ionic products of Bioglass 45S5 dissolution on osteoblast proliferation may be mediated by IGF-II.
Journal ArticleDOI
Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review
Susmita Bose,Solaiman Tarafder +1 more
TL;DR: This review highlights some of the current drug and growth factor delivery approaches and critical issues using CaP particles, coatings, cements, and scaffolds towards orthopedic and dental applications.