Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics
TLDR
This review highlights the use of trace elements in CaP biomaterials, and offers an insight into the mechanisms of how metal ions can enhance both osteogenesis and angiogenesis.About:
This article is published in Trends in Biotechnology.The article was published on 2013-10-01 and is currently open access. It has received 387 citations till now.read more
Citations
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Bone grafts and biomaterials substitutes for bone defect repair: A review.
Wenhao Wang,Kelvin W.K. Yeung +1 more
TL;DR: The currently available bone grafts and bone substitutes as well as the biological and bio-inorganic factors for the treatments of bone defect are reviewed.
Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity
TL;DR: It is demonstrated that it is possible to develop multifunctional scaffolds by combining enhanced angiogenesis potential, osteostimulation, and antibacterial properties for the treatment of large bone defects.
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Additive manufacturing of biomaterials.
TL;DR: Key additive manufacturing methods are first introduced followed by AM of different materials, and finally applications of AM in various treatment options are reviewed.
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Bioactive Glasses: Sprouting Angiogenesis in Tissue Engineering
Saeid Kargozar,Francesco Baino,Sepideh Hamzehlou,Sepideh Hamzehlou,Robert G. Hill,Masoud Mozafari +5 more
TL;DR: The salient features, the hurdles that must be overcome, and the hopes and constraints for the development of BGs with improved angiogenetic properties are introduced.
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Biomimetic Materials and Fabrication Approaches for Bone Tissue Engineering.
Hwan Kim,Sivashanmugam Amirthalingam,Seung Hyun Kim,Seung-Hun Lee,Jayakumar Rangasamy,Nathaniel S. Hwang +5 more
TL;DR: In this article, a progress report of biomimetic materials and fabrication approaches that are currently being utilized for biomimic scaffold design are reviewed, including 3D printing methods, for optimal host stem cell infiltration, vascularization, nutrient transfer, and stem cell differentiation.
References
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Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro
David Reffitt,N. Ogston,Ravin Jugdaohsingh,H. F. J. Cheung,Bronwen Alice James Evans,Richard P. H. Thompson,Jonathan J. Powell,Geeta Hampson +7 more
TL;DR: In conclusion, orthosilicic acid at physiological concentrations stimulates collagen type 1 synthesis in human osteoblast-like cells and enhances osteoblastic differentiation.
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Collagen sponges for bone regeneration with rhBMP-2.
M Geiger,R H Li,Wolfgang Friess +2 more
TL;DR: Several factors involved in the preparation of adequate matrices, specifically collagen sponges, were investigated in order to test the performance in a new role as an implant providing local delivery of an osteoinductive differentiation factor.
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Angiogenesis and bone repair.
TL;DR: The role of osteogenic factors in the adaptive response and interactive function of OB and EC during the multi-step process of bone repair will be discussed.
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Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion
Lisa B. E. Shields,George H. Raque,Steven D. Glassman,Mitchell J. Campbell,Todd W. Vitaz,John E. Harpring,Christopher B. Shields +6 more
TL;DR: It is hypothesized that in the cervical area, the putative inflammatory effect that contributes to the effectiveness of INFUSE® in inducing fusion may spread to adjacent critical structures and lead to increased postoperative morbidity.
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Activation of the Wnt Signaling Pathway: A Molecular Mechanism for Lithium Action
Chester M. Hedgepeth,Leslee J. Conrad,Jie Zhang,Hui-Chuan Huang,Virginia M.-Y. Lee,Peter S. Klein +5 more
TL;DR: It is shown that lithium inhibits GSK-3 beta from species as diverse as Dictyostelium discoideum and Xenopus laevis, providing a biochemical mechanism for the action of lithium on the development of these organisms.