Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics
TLDR
This review highlights the use of trace elements in CaP biomaterials, and offers an insight into the mechanisms of how metal ions can enhance both osteogenesis and angiogenesis.About:
This article is published in Trends in Biotechnology.The article was published on 2013-10-01 and is currently open access. It has received 387 citations till now.read more
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Towards modular bone tissue engineering using Ti-Co-doped phosphate glass microspheres: cytocompatibility and dynamic culture studies.
Carlotta Peticone,David De Silva Thompson,Gareth J Owens,Hae-Won Kim,Martina Micheletti,Jonathan C. Knowles,Jonathan C. Knowles,Ivan Wall,Ivan Wall +8 more
TL;DR: Ti–Co phosphate glasses were found to support osteoblastic cell growth and aggregate formation that is a necessary precursor to tissue formation and the upregaulation of VEGF production can potentially support vascularization.
Journal ArticleDOI
Hierarchical porosity inherited by natural sources affects the mechanical and biological behaviour of bone scaffolds
Simone Sprio,Silvia Panseri,Monica Montesi,Massimiliano Dapporto,Andrea Ruffini,Samuele M. Dozio,Riccardo Cavuoto,Diego Misseroni,Marco Paggi,Davide Bigoni,Anna Tampieri +10 more
TL;DR: In this article, a 3D porous apatite scaffold (B-HA), recently obtained through biomorphic transformation of a natural wood, is investigated on its multi-scale porous structure determining superior biological and mechanical behaviour.
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Copper peptide-incorporated 3D-printed silk-based scaffolds promote vascularized bone regeneration
Mingliang Zhou,Xiaolin Wu,Jiaxin Luo,Guangzheng Yang,Yuezhi Lu,Sihan Lin,Fei Jiang,Fei Jiang,Wenjie Zhang,Xinquan Jiang +9 more
TL;DR: 3D-printed silk-based scaffolds with sustained release of copper peptide, a copper ion-specific binding tripeptide, were fabricated and exhibited similar therapeutic effects to free copper ions, with lower toxicity.
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Enhancing Bioactivity of Hydroxyapatite Scaffolds Using Fibrous Type I Collagen.
Paola Nitti,Sanosh Kunjalukkal Padmanabhan,Serena Cortazzi,Eleonora Stanca,Luisa Siculella,Antonio Licciulli,Christian Demitri +6 more
Abstract: In the field of bone tissue regeneration, the development of osteoconductive and osteoinductive scaffolds is an open challenge The purpose of this work was the design and characterization of composite structures made of hydroxyapatite scaffold impregnated with a collagen slurry in order to mimic the bone tissue structure The effect of magnesium and silicon ions enhancing both mechanical and biological properties of partially substituted hydroxyapatite were evaluated and compared with that of pure hydroxyapatite The use of an innovative freeze-drying approach was developed, in which composite scaffolds were immersed in cold water, frozen and then lyophilized, thereby creating an open-pore structure, an essential feature for tissue regeneration The mechanical stability of bone scaffolds is very important in the first weeks of slow bone regeneration process Therefore, the biodegradation behavior of 3D scaffolds was evaluated by incubating them for different periods of time in Tris-HCl buffer The microstructure observation, the weight loss measurements and mechanical stability up to 28 days of incubation (particularly for HA-Mg_Coll scaffolds), revealed moderate weight loss and mechanical performances reduction due to collagen dissolution At the same time, the presence of collagen helps to protect the ceramic structure until it degrades These results, combined with MTT tests, confirm that HA-Mg_Coll scaffolds may be the suitable candidate for bone remodeling
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Improved osseointegration of strontium-modified titanium implants by regulating angiogenesis and macrophage polarization.
TL;DR: It is demonstrated that the angiogenic capacity of human umbilical vein endothelial cells on the Sr-incorporated micro/nano titanium (SLA-Sr) surface was also significantly improved through the up-regulated expression of the HIF-1α protein and Erk1/2 phosphorylation.
References
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TL;DR: Results obtained from available animal studies suggest that the compound is protective, and further studies are needed to better understand the cellular effects of this essential, but potentially toxic, trace mineral and its functional interaction with other nutrients.
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Pierre J. Meunier,Christian Roux,Ego Seeman,Sergio Ortolani,J. Badurski,Tim D. Spector,J. Cannata,Adam Balogh,EM Lemmel,S. Pors-Nielsen,René Rizzoli,Harry K. Genant,Jean-Yves Reginster +12 more
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Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis.
TL;DR: It is suggested that the stimulatory effect of the ionic products of Bioglass 45S5 dissolution on osteoblast proliferation may be mediated by IGF-II.
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Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review
Susmita Bose,Solaiman Tarafder +1 more
TL;DR: This review highlights some of the current drug and growth factor delivery approaches and critical issues using CaP particles, coatings, cements, and scaffolds towards orthopedic and dental applications.