Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics
TLDR
This review highlights the use of trace elements in CaP biomaterials, and offers an insight into the mechanisms of how metal ions can enhance both osteogenesis and angiogenesis.About:
This article is published in Trends in Biotechnology.The article was published on 2013-10-01 and is currently open access. It has received 387 citations till now.read more
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Bioactive glass-based nanocomposites for personalized dental tissue regeneration.
TL;DR: This review focuses on a variety of processes and practical applications of BGNs and their derivatives, which is expected to aid readerships with understanding and employing B GNs andtheir derivatives for personalized dental treatments.
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Development of a synthetic tissue engineered three-dimensional printed bioceramic-based bone graft with homogenously distributed osteoblasts and mineralizing bone matrix in vitro.
Doaa Adel-Khattab,Doaa Adel-Khattab,Francesca Giacomini,Renate Gildenhaar,Georg Berger,Cynthia M. Gomes,Ulf Linow,Martin Hardt,Barbara Peleska,Jens Günster,Michael Stiller,Alireza Houshmand,Khaled Abdel Ghaffar,Ahmed Y. Gamal,Mohamed El-Mofty,Christine Knabe +15 more
TL;DR: 3D‐printed scaffolds (RPS) displayed superior mechanical and biological properties and facilitated generating a tissue engineered synthetic bone graft in vitro, which mimics the advantageous properties of autogenous bone grafts, by containing homogenously distributed terminally differentiated osteoblasts and mineralizing bone matrix and therefore is suitable for subsequent in vivo implantation for regenerating segmental discontinuity bone defects.
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Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold
Antonia Ressler,Antonia Ressler,Maja Antunović,Laura Teruel-Biosca,Gloria Gallego Ferrer,Slaven Babić,Inga Urlić,Marica Ivanković,Hrvoje Ivanković +8 more
TL;DR: In this paper, highly porous composite scaffolds based on CaPs substituted with Sr2+, Mg2+, Zn2+ and SeO32− ions, and chitosan have been prepared by freeze-gelation technique.
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Synthesis and investigations of mineral ions-loaded apatite from fish scale and PLA/chitosan composite for bone scaffolds
Weeraphat Pon-On,Panan Suntornsaratoon,Narattaphol Charoenphandhu,Jirawan Thongbunchoo,Nateetip Krishnamra,I. Ming Tang +5 more
TL;DR: In this article, a composite scaffolds consisting of mineral ion-loaded hydroxyapatite derived from fish scale (mHAFS) in a poly(lactic acid) (PLA)/chitosan (Chi) matrix were fabricated by an in situ blending technique.
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Recent developments in strontium-based biocomposites for bone regeneration
TL;DR: Different categories of recently explored strontium-integrated biomaterials, including calcium silicate, calcium phosphate, bioglasses and polymer-based synthetic implants along with their in vivo bone formation efficacies and/or in vitro cell responses are presented.
References
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Lisa M. Gaetke,Ching Kuang Chow +1 more
TL;DR: Results obtained from available animal studies suggest that the compound is protective, and further studies are needed to better understand the cellular effects of this essential, but potentially toxic, trace mineral and its functional interaction with other nutrients.
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Roland Baron,Michaela Kneissel +1 more
TL;DR: Current understanding of the mechanisms by which WNT signalng regulates bone homeostasis is reviewed, finding the pathway is now the target for therapeutic intervention to restore bone strength in millions of patients at risk for fracture.
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The Effects of Strontium Ranelate on the Risk of Vertebral Fracture in Women with Postmenopausal Osteoporosis
Pierre J. Meunier,Christian Roux,Ego Seeman,Sergio Ortolani,J. Badurski,Tim D. Spector,J. Cannata,Adam Balogh,EM Lemmel,S. Pors-Nielsen,René Rizzoli,Harry K. Genant,Jean-Yves Reginster +12 more
TL;DR: Treatment of postmenopausal osteoporosis with strontium ranelate leads to early and sustained reductions in the risk of vertebral fractures.
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Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis.
TL;DR: It is suggested that the stimulatory effect of the ionic products of Bioglass 45S5 dissolution on osteoblast proliferation may be mediated by IGF-II.
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Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review
Susmita Bose,Solaiman Tarafder +1 more
TL;DR: This review highlights some of the current drug and growth factor delivery approaches and critical issues using CaP particles, coatings, cements, and scaffolds towards orthopedic and dental applications.