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Open AccessJournal ArticleDOI

Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics

TLDR
This review highlights the use of trace elements in CaP biomaterials, and offers an insight into the mechanisms of how metal ions can enhance both osteogenesis and angiogenesis.
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This article is published in Trends in Biotechnology.The article was published on 2013-10-01 and is currently open access. It has received 387 citations till now.

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Journal ArticleDOI

Synthesis by solid route and physicochemical characterizations of blends of calcium orthophosphate powders and mesoporous silicon particles

TL;DR: In this article , the authors investigated the synthesis of economic calcium phosphate powders from recycled oyster shells using a ball milling method and characterized the final powders using X-ray diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy.
Journal ArticleDOI

Chitosan/collagen/Mg, Se, Sr, Zn-substituted calcium phosphate scaffolds for bone tissue engineering applications: A growth factor free approach

TL;DR: Wang et al. as mentioned in this paper improved the properties of growth factor-free scaffolds by adding collagen into the chitosan matrix at weight ratios of 100:0, 75:25, 50:50, 25:75 and 0:100.
Journal ArticleDOI

One-step co-doping of ZnO and Zn2+ in osteoinductive calcium phosphate ceramics with synergistic antibacterial activity for regenerative repair of infected bone defect

TL;DR: In this paper , the synergistic antibacterial mechanism of zinc oxide and zinc ion co-doping in biphasic calcium phosphate (BCP) ceramics was investigated and the results indicated that the simultaneous introduction of ZnO/Zn2+ could have immense potential to expand the application of osteoinductive BCP-ceramics in the regenerative repair of infected bone defects.
Journal ArticleDOI

Lanthanides-Substituted Hydroxyapatite for Biomedical Applications

TL;DR: In this article , a comprehensive review of the applications of lanthanides-substituted HAp nanoparticles (HAp NPs) is presented to unveil the potential biomedical uses of these systems and the need to study the tolerable and non-toxic percentages of substitution with these elements is highlighted.
Book ChapterDOI

Synthesis of Hydroxyapatite from Biogenic Resources

TL;DR: In this paper , the main inorganic component present in bones and teeth of vertebrate is synthesized from natural resources, such as Mg, Na, F, and Sr. The authors tried to summarize the HAp extraction methods, which are used to synthesize HAp from biogenic resources.
References
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Journal ArticleDOI

Copper toxicity, oxidative stress, and antioxidant nutrients.

TL;DR: Results obtained from available animal studies suggest that the compound is protective, and further studies are needed to better understand the cellular effects of this essential, but potentially toxic, trace mineral and its functional interaction with other nutrients.
Journal ArticleDOI

WNT signaling in bone homeostasis and disease: from human mutations to treatments

TL;DR: Current understanding of the mechanisms by which WNT signalng regulates bone homeostasis is reviewed, finding the pathway is now the target for therapeutic intervention to restore bone strength in millions of patients at risk for fracture.
Journal ArticleDOI

Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis.

TL;DR: It is suggested that the stimulatory effect of the ionic products of Bioglass 45S5 dissolution on osteoblast proliferation may be mediated by IGF-II.
Journal ArticleDOI

Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review

TL;DR: This review highlights some of the current drug and growth factor delivery approaches and critical issues using CaP particles, coatings, cements, and scaffolds towards orthopedic and dental applications.
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