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Open AccessJournal ArticleDOI

Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics

TLDR
This review highlights the use of trace elements in CaP biomaterials, and offers an insight into the mechanisms of how metal ions can enhance both osteogenesis and angiogenesis.
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This article is published in Trends in Biotechnology.The article was published on 2013-10-01 and is currently open access. It has received 387 citations till now.

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Journal ArticleDOI

Synchrotron SAXS/WAXS and TEM studies of zinc doped natural hydroxyapatite nanoparticles and their evaluation on osteogenic differentiation of human mesenchymal stem cells

TL;DR: In this article , the osteogenic differentiation impact of nanoparticles was investigated on mesenchymal stem cells using alizarin red staining (ARS) and real timequantitative polymerase chain reaction (RT-PCR) analyses.
Journal ArticleDOI

Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine

TL;DR: The combination of Li-doped bioceramics with polymers can provide new biomaterials with suitable flexibility, especially as bio-ink used in 3D printing for clinical applications of tissue engineering.
Journal ArticleDOI

A novel peptide hydrogel of metal ion clusters for accelerating bone defect regeneration.

TL;DR: In this paper , a self-assembled chelating peptide hydrogel loaded with an osteogenic metal ion cluster extracted from the processed pyritum decoction, including Fe2+, Cu2+, Zn2+, Mn2+, Mg2+, and Ca2+ ions, was used to accelerate the progress of various bone healing stages, and shortened the bone healing cycle by 4 weeks.
Book ChapterDOI

Industrial implementations of biocomposites

TL;DR: In this paper, various types of biocomposites based on ceramics, polymers, and metals are discussed for their industrial applications with corresponding physical, chemical or mechanical properties.
Journal ArticleDOI

Biocompatible hydroxyapatite ceramic coating on titanium alloys by electrochemical methods via Growing Integration Layers [GIL] strategy: A review

TL;DR: The Growing Integration Layers (GIL) method as discussed by the authors is a noble approach for the application of biocompatible oxide ceramics layers coating on bulk metallic alloys, which differs significantly from so-called layer-by-layer integration, layers are deposited from top-to-top.
References
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Journal ArticleDOI

Copper toxicity, oxidative stress, and antioxidant nutrients.

TL;DR: Results obtained from available animal studies suggest that the compound is protective, and further studies are needed to better understand the cellular effects of this essential, but potentially toxic, trace mineral and its functional interaction with other nutrients.
Journal ArticleDOI

WNT signaling in bone homeostasis and disease: from human mutations to treatments

TL;DR: Current understanding of the mechanisms by which WNT signalng regulates bone homeostasis is reviewed, finding the pathway is now the target for therapeutic intervention to restore bone strength in millions of patients at risk for fracture.
Journal ArticleDOI

Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis.

TL;DR: It is suggested that the stimulatory effect of the ionic products of Bioglass 45S5 dissolution on osteoblast proliferation may be mediated by IGF-II.
Journal ArticleDOI

Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review

TL;DR: This review highlights some of the current drug and growth factor delivery approaches and critical issues using CaP particles, coatings, cements, and scaffolds towards orthopedic and dental applications.
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