Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics
TLDR
This review highlights the use of trace elements in CaP biomaterials, and offers an insight into the mechanisms of how metal ions can enhance both osteogenesis and angiogenesis.About:
This article is published in Trends in Biotechnology.The article was published on 2013-10-01 and is currently open access. It has received 387 citations till now.read more
Citations
More filters
Journal ArticleDOI
Comprehensive In Vitro Testing of Calcium Phosphate-Based Bioceramics with Orthopedic and Dentistry Applications
Radu Albulescu,Adrian-Claudiu Popa,Ana-Maria Enciu,Lucian Albulescu,Maria Dudau,Ionela Daniela Popescu,Simona Mihai,Elena Codrici,Sevinci Pop,Andreea-Roxana Lupu,George E. Stan,Gina Manda,Cristiana Tanase +12 more
TL;DR: In this review, current molecular techniques are assessed for the in-depth characterization of angiogenic potential, osteogenic capability, and the modulation of oxidative stress and inflammation properties of CaPs and their cation- and/or anion-substituted derivatives.
Journal ArticleDOI
Micro or nano: Evaluation of biosafety and biopotency of magnesium metal organic framework-74 with different particle sizes
Zhou Zhu,Shaokang Jiang,Yanhua Liu,Xiaomeng Gao,Shanshan Hu,Xin Zhang,Chao Huang,Qianbing Wan,Jian Wang,Xibo Pei +9 more
TL;DR: In this paper, the effect of the particle size change of the magnesium metal organic framework-74 (Mg-MOF74) was evaluated in vitro and in vivo toxicity of micron/nanoscale particles of the same material.
Journal ArticleDOI
Combinatorial incorporation of fluoride and cobalt ions into calcium phosphates to stimulate osteogenesis and angiogenesis
Zeinab Tahmasebi Birgani,Nazli Gharraee,Angad Malhotra,Angad Malhotra,Clemens van Blitterswijk,Clemens van Blitterswijk,Pamela Habibovic,Pamela Habibovic +7 more
TL;DR: The incorporation of cobalt and fluoride into CaPs is a promising method to improve the biological performance of fully synthetic bone graft substitutes and demonstrates an approach to simultaneously target the two essential mechanisms in bone healing: angiogenesis and osteogenesis.
Journal ArticleDOI
Enhanced Osteogenesis of Nanosized Cobalt-substituted Hydroxyapatite
Nenad Ignjatović,Zorica Ajdukovic,Jelena Rajković,Stevo Najman,Dragan Mihailovic,Dragan Uskoković +5 more
TL;DR: In this paper, the osteogenetic potential of synthesized hydroxyapatite (HAp) and Co2+-substituted HAp was analyzed in vivo with the aim of stimulating osteogenesis in vivo.
Journal ArticleDOI
Biological behavior of bioactive glasses and their composites
Saba Zahid,Asma Tufail Shah,Arshad Jamal,Aqif Anwar Chaudhry,Abdul Samad Khan,Ather Farooq Khan,Nawshad Muhammad,Ihtesham Ur Rehman +7 more
TL;DR: A main focus was given to highlight the role of BGs and their composites in osteogenic differentiation and angiogenesis, followed by their cytotoxicity, protein adsorption ability and antibacterial properties.
References
More filters
Journal ArticleDOI
Copper toxicity, oxidative stress, and antioxidant nutrients.
Lisa M. Gaetke,Ching Kuang Chow +1 more
TL;DR: Results obtained from available animal studies suggest that the compound is protective, and further studies are needed to better understand the cellular effects of this essential, but potentially toxic, trace mineral and its functional interaction with other nutrients.
Journal ArticleDOI
WNT signaling in bone homeostasis and disease: from human mutations to treatments
Roland Baron,Michaela Kneissel +1 more
TL;DR: Current understanding of the mechanisms by which WNT signalng regulates bone homeostasis is reviewed, finding the pathway is now the target for therapeutic intervention to restore bone strength in millions of patients at risk for fracture.
Journal ArticleDOI
The Effects of Strontium Ranelate on the Risk of Vertebral Fracture in Women with Postmenopausal Osteoporosis
Pierre J. Meunier,Christian Roux,Ego Seeman,Sergio Ortolani,J. Badurski,Tim D. Spector,J. Cannata,Adam Balogh,EM Lemmel,S. Pors-Nielsen,René Rizzoli,Harry K. Genant,Jean-Yves Reginster +12 more
TL;DR: Treatment of postmenopausal osteoporosis with strontium ranelate leads to early and sustained reductions in the risk of vertebral fractures.
Journal ArticleDOI
Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis.
TL;DR: It is suggested that the stimulatory effect of the ionic products of Bioglass 45S5 dissolution on osteoblast proliferation may be mediated by IGF-II.
Journal ArticleDOI
Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review
Susmita Bose,Solaiman Tarafder +1 more
TL;DR: This review highlights some of the current drug and growth factor delivery approaches and critical issues using CaP particles, coatings, cements, and scaffolds towards orthopedic and dental applications.