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Angeline S. Andrew
Researcher at Dartmouth–Hitchcock Medical Center
Publications - 33
Citations - 1687
Angeline S. Andrew is an academic researcher from Dartmouth–Hitchcock Medical Center. The author has contributed to research in topics: Lung cancer & Genome-wide association study. The author has an hindex of 11, co-authored 33 publications receiving 1198 citations. Previous affiliations of Angeline S. Andrew include Dartmouth College.
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Journal ArticleDOI
Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study
Robert Carreras-Torres,Mattias Johansson,Philip C Haycock,Kaitlin H Wade,Caroline L Relton,Richard M. Martin,Richard M. Martin,George Davey Smith,Demetrius Albanes,Melinda C. Aldrich,Angeline S. Andrew,Susanne M. Arnold,Heike Bickeböller,Stig E. Bojesen,Hans Brunnström,Jonas Manjer,Irene Brüske,Neil E. Caporaso,Chu Chen,David C. Christiani,W. Jay Christian,Jennifer A. Doherty,Eric J. Duell,John K. Field,Michael P.A. Davies,Michael W. Marcus,Gary E. Goodman,Kjell Grankvist,Aage Haugen,Yun-Chul Hong,Lambertus A. Kiemeney,Erik H.F.M. van der Heijden,Peter Kraft,Mikael Johansson,Stephen Lam,Maria Teresa Landi,Philip Lazarus,Loic Le Marchand,Geoffrey Liu,Olle Melander,Sungshim L. Park,Gad Rennert,Angela Risch,Eric B. Haura,Ghislaine Scelo,David Zaridze,Anush Mukeriya,Milan Savic,Jolanta Lissowska,Beata Swiatkowska,Vladimir Janout,Ivana Holcatova,Dana Mates,Matthew B. Schabath,Hongbing Shen,Adonina Tardón,M. Dawn Teare,Penella J. Woll,Ming-Sound Tsao,Xifeng Wu,Jian-Min Yuan,Rayjean J. Hung,Christopher I. Amos,James D. McKay,Paul Brennan +64 more
TL;DR: The results are consistent with a causal role of fasting insulin and low-density lipoprotein cholesterol in lung cancer etiology, as well as for BMI in squamous cell and small cell carcinoma, and the latter relation may be mediated by a previously unrecognized effect of obesity on smoking behavior.
Journal ArticleDOI
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
James D. McKay,Rayjean J. Hung,Younghun Han,Xuchen Zong,Robert Carreras-Torres,David C. Christiani,Neil E. Caporaso,Mattias Johansson,Xiangjun Xiao,Yafang Li,Jinyoung Byun,Alison M. Dunning,Karen A. Pooley,David C. Qian,Xuemei Ji,Geoffrey Liu,Maria Timofeeva,Stig E. Bojesen,Stig E. Bojesen,Stig E. Bojesen,Xifeng Wu,Loic Le Marchand,Demetrios Albanes,Heike Bickeböller,Melinda C. Aldrich,William S. Bush,Adonina Tardón,Gad Rennert,M. Dawn Teare,John K. Field,Lambertus A. Kiemeney,Philip Lazarus,Aage Haugen,Stephen Lam,Matthew B. Schabath,Angeline S. Andrew,Hongbing Shen,Yun Chul Hong,Jian-Min Yuan,Pier Alberto Bertazzi,Angela Cecilia Pesatori,Yuanqing Ye,Nancy Diao,Li Su,Ruyang Zhang,Yonathan Brhane,Natasha B. Leighl,Jakob S Johansen,Anders Mellemgaard,Walid Saliba,Christopher A. Haiman,Lynne R. Wilkens,Ana Fernández-Somoano,Guillermo Fernández-Tardón,Henricus F. M. van der Heijden,Jin Hee Kim,Juncheng Dai,Zhibin Hu,Michael P.A. Davies,Michael W. Marcus,Hans Brunnström,Jonas Manjer,Olle Melander,David C. Muller,Kim Overvad,Antonia Trichopoulou,Rosario Tumino,Jennifer A. Doherty,Matt P Barnett,Chu Chen,Gary E. Goodman,Angela Cox,Fiona Taylor,Penella J. Woll,Irene Brüske,H-Erich Wichmann,H-Erich Wichmann,Judith Manz,Thomas Muley,Angela Risch,Albert Rosenberger,Kjell Grankvist,Mikael Johansson,Frances A. Shepherd,Ming-Sound Tsao,Susanne M. Arnold,Eric B. Haura,Ciprian Bolca,Ivana Holcatova,Vladimir Janout,Milica Kontic,Jolanta Lissowska,Anush Mukeria,Simona Ognjanovic,Tadeusz M Orlowski,Ghislaine Scelo,Beata Swiatkowska,David Zaridze,Per Bakke,Vidar Skaug,Shanbeh Zienolddiny,Eric J. Duell,Lesley M. Butler,Woon-Puay Koh,Yu-Tang Gao,Richard S. Houlston,John McLaughlin,Victoria L. Stevens,Philippe Joubert,Maxime Lamontagne,David C. Nickle,Ma'en Obeidat,Wim Timens,Bin Zhu,Lei Song,Linda Kachuri,María Soler Artigas,María Soler Artigas,Martin D. Tobin,Martin D. Tobin,Louise V. Wain,Louise V. Wain,Thorunn Rafnar,Thorgeir E. Thorgeirsson,Gunnar W Reginsson,Kari Stefansson,Dana B. Hancock,Laura J. Bierut,Margaret R. Spitz,Nathan C. Gaddis,Sharon M. Lutz,Fangyi Gu,Eric O. Johnson,Ahsan Kamal,Claudio W. Pikielny,Dakai Zhu,Sara Lindstroem,Xia Jiang,Rachel F. Tyndale,Rachel F. Tyndale,Georgia Chenevix-Trench,Jonathan Beesley,Yohan Bossé,Stephen J. Chanock,Paul Brennan,Maria Teresa Landi,Christopher I. Amos +146 more
TL;DR: 18 susceptibility loci achieving genome-wide significance are identified, including 10 new loci linked with lung cancer overall and six loci associated with lung adenocarcinoma, highlighting the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer.
Journal ArticleDOI
Shared heritability and functional enrichment across six solid cancers
Xia Jiang,Hilary K. Finucane,Fredrick R. Schumacher,Stephanie L. Schmit,Jonathan Tyrer,Younghun Han,Kyriaki Michailidou,Corina Lesseur,Karoline Kuchenbaecker,Joe Dennis,David V. Conti,Graham Casey,Mia M. Gaudet,Jeroen R. Huyghe,Demetrius Albanes,Melinda C. Aldrich,Angeline S. Andrew,Irene L. Andrulis,Hoda Anton-Culver,Antonis C. Antoniou,Natalia Antonenkova,Susanne M. Arnold,Kristan J. Aronson,Banu Arun,Elisa V. Bandera,Rosa B. Barkardottir,Daniel R. Barnes,Jyotsna Batra,Matthias W. Beckmann,Javier Benitez,Sara Benlloch,Andrew Berchuck,Sonja I. Berndt,Heike Bickeböller,Stephanie A. Bien,Carl Blomqvist,Stefania Boccia,Natalia Bogdanova,Stig E. Bojesen,Manjeet K. Bolla,Hiltrud Brauch,Hermann Brenner,James D. Brenton,Mark N. Brook,Joan Brunet,Hans Brunnström,Daniel D. Buchanan,Barbara Burwinkel,Ralf Bützow,Gabriella Cadoni,Trinidad Caldés,Maria A. Caligo,Ian G. Campbell,Peter T. Campbell,Geraldine Cancel-Tassin,Lisa A. Cannon-Albright,Daniele Campa,Neil E. Caporaso,André Lopes Carvalho,Andrew T. Chan,Jenny Chang-Claude,Stephen J. Chanock,Chu Chen,David C. Christiani,Kathleen Claes,Frank Claessens,Judith A. Clements,J. Margriet Collée,Marcia Cruz Correa,Fergus J. Couch,Angela Cox,Julie M. Cunningham,Cezary Cybulski,Kamila Czene,Mary B. Daly,Anna deFazio,Peter Devilee,Orland Diez,Manuela Gago-Dominguez,Jenny L Donovan,Thilo Dörk,Eric J. Duell,Alison M. Dunning,Miriam Dwek,Diana Eccles,Christopher K. Edlund,Digna R. Velez Edwards,Carolina Ellberg,D. Gareth Evans,Peter A. Fasching,Robert L. Ferris,Triantafillos Liloglou,Jane C. Figueiredo,Olivia Fletcher,Renée T. Fortner,Florentia Fostira,Silvia Franceschi,Eitan Friedman,Steven Gallinger,Patricia A. Ganz,Judy Garber,José A. García-Sáenz,Simon A. Gayther,Graham G. Giles,Andrew K. Godwin,Mark S. Goldberg,David E. Goldgar,Ellen L. Goode,Marc T. Goodman,Gary E. Goodman,Kjell Grankvist,Mark H. Greene,Henrik Grönberg,Jacek Gronwald,Pascal Guénel,Niclas Håkansson,Per Hall,Ute Hamann,Freddie C. Hamdy,Robert J. Hamilton,Jochen Hampe,Aage Haugen,Florian Heitz,Rolando Herrero,Peter Hillemanns,Michael Hoffmeister,Estrid Høgdall,Yun-Chul Hong,John L. Hopper,Richard S. Houlston,Peter J. Hulick,David J. Hunter,David G. Huntsman,Gregory Idos,Evgeny N. Imyanitov,Sue A. Ingles,Claudine Isaacs,Anna Jakubowska,Paul A. James,Mark A. Jenkins,Mattias Johansson,Mikael Johansson,Esther M. John,Amit Joshi,Radka Kaneva,Beth Y. Karlan,Linda E. Kelemen,Tabea Kühl,Kay-Tee Khaw,Elza Khusnutdinova,Adam S. Kibel,Lambertus A. Kiemeney,Jeri Kim,Susanne K. Kjaer,Julia A. Knight,Manolis Kogevinas,Zsofia Kote-Jarai,Stella Koutros,Vessela N. Kristensen,Jolanta Kupryjanczyk,Martin Lacko,Stephan Lam,Diether Lambrechts,Maria Teresa Landi,Philip Lazarus,Nhu D. Le,Eunjung Lee,Flavio Lejbkowicz,Heinz-Josef Lenz,Goska Leslie,Davor Lessel,Jenny Lester,Douglas A. Levine,Li Li,Christopher I. Li,Annika Lindblom,Noralane M. Lindor,Geoffrey Liu,Fotios Loupakis,Jan Lubinski,Lovise Maehle,Christiane Maier,Arto Mannermaa,Loic Le Marchand,Sara Margolin,Taymaa May,Lesley McGuffog,Alfons Meindl,Pooja Middha,Austin Miller,Roger L. Milne,Robert J. MacInnis,Francesmary Modugno,Marco Montagna,Victor Moreno,Kirsten B. Moysich,Lorelei A. Mucci,Kenneth Muir,Anna Marie Mulligan,Katherine L. Nathanson,David E. Neal,Andy R Ness,Susan L. Neuhausen,Heli Nevanlinna,Polly A. Newcomb,Lisa F. Newcomb,Finn Cilius Nielsen,Liene Nikitina-Zake,Børge G. Nordestgaard,Robert L. Nussbaum,Kenneth Offit,Edith Olah,Ali Amin Al Olama,Olufunmilayo I. Olopade,Andrew F. Olshan,Håkan Olsson,Ana Osorio,Hardev Pandha,Jong Y. Park,Nora Pashayan,Michael T. Parsons,Tanja Pejovic,Kathryn L. Penney,Wilbert H.M. Peters,Catherine M. Phelan,Amanda I. Phipps,Dijana Plaseska-Karanfilska,Miranda Pring,Darya Prokofyeva,Paolo Radice,Kari Stefansson,Susan J. Ramus,Leon Raskin,Gad Rennert,Hedy S. Rennert,Elizabeth J. van Rensburg,Marjorie J. Riggan,Harvey A. Risch,Angela Risch,Monique J. Roobol,Barry S. Rosenstein,Mary Anne Rossing,Kim De Ruyck,Emmanouil Saloustros,Dale P. Sandler,Elinor J. Sawyer,Matthew B. Schabath,Johanna Schleutker,Marjanka K. Schmidt,V. Wendy Setiawan,Hongbing Shen,Erin M. Siegel,Weiva Sieh,Christian F. Singer,Martha L. Slattery,Karina Dalsgaard Sørensen,Melissa C. Southey,Amanda B. Spurdle,Janet L. Stanford,Victoria L. Stevens,Sebastian Stintzing,Jennifer Stone,Karin Sundfeldt,Rebecca Sutphen,Anthony J. Swerdlow,Eloiza H. Tajara,Catherine M. Tangen,Adonina Tardón,Jack A. Taylor,M. Dawn Teare,Manuel R. Teixeira,Mary Beth Terry,Kathryn L. Terry,Stephen N. Thibodeau,Mads Thomassen,Line Bjørge,Marc Tischkowitz,Amanda E. Toland,Diana Torres,Paul A. Townsend,Ruth C. Travis,Nadine Tung,Shelley S. Tworoger,Cornelia M. Ulrich,Nawaid Usmani,Celine M. Vachon,Els Van Nieuwenhuysen,Ana Vega,Miguel E. Aguado-Barrera,Qin Wang,Penelope M. Webb,Clarice R. Weinberg,Stephanie J. Weinstein,Mark C. Weissler,Jeffrey N. Weitzel,Catharine M L West,Emily White,Emily White,Alice S. Whittemore,H-Erich Wichmann,Fredrik Wiklund,Robert Winqvist,Alicja Wolk,Penella J. Woll,Michael O. Woods,Anna H. Wu,Xifeng Wu,Drakoulis Yannoukakos,Wei Zheng,Shanbeh Zienolddiny,Argyrios Ziogas,Kristin K. Zorn,Jacqueline M. Lane,Richa Saxena,Duncan Thomas,Rayjean J. Hung,Brenda Diergaarde,James D. McKay,Ulrike Peters,Li Hsu,Montserrat Garcia-Closas,Rosalind A. Eeles,Georgia Chenevix-Trench,Paul Brennan,Christopher A. Haiman,Jacques Simard,Douglas F. Easton,Stephen B. Gruber,Paul D.P. Pharoah,Alkes L. Price,Bogdan Pasaniuc,Christopher I. Amos,Peter Kraft,Sara Lindström +333 more
TL;DR: The authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry to show that solid tumours arising from different tissues share a degree of common germline genetic basis.
Journal ArticleDOI
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
Xuemei Ji,Yohan Bossé,Maria Teresa Landi,Jiang Gui,Xiangjun Xiao,David C. Qian,Philippe Joubert,Maxime Lamontagne,Yafang Li,Ivan P. Gorlov,Mariella De Biasi,Younghun Han,Olga Y. Gorlova,Rayjean J. Hung,Xifeng Wu,James D. McKay,Xuchen Zong,Robert Carreras-Torres,David C. Christiani,Neil E. Caporaso,Mattias Johansson,Geoffrey Liu,Stig E. Bojesen,Stig E. Bojesen,Stig E. Bojesen,Loic Le Marchand,Demetrios Albanes,Heike Bickeböller,Melinda C. Aldrich,William S. Bush,William S. Bush,Adonina Tardón,Gad Rennert,Chu Chen,M. Dawn Teare,John K. Field,Lambertus A. Kiemeney,Philip Lazarus,Aage Haugen,Stephen Lam,Matthew B. Schabath,Angeline S. Andrew,Hongbing Shen,Yun-Chul Hong,Jian-Min Yuan,Pier Alberto Bertazzi,Angela Cecilia Pesatori,Yuanqing Ye,Nancy Diao,Li Su,Ruyang Zhang,Ruyang Zhang,Yonathan Brhane,Natasha B. Leighl,Jakob S Johansen,Anders Mellemgaard,Walid Saliba,Christopher A. Haiman,Lynne R. Wilkens,Ana Fernández-Somoano,Guillermo Fernández-Tardón,Erik H.F.M. van der Heijden,Jin Hee Kim,Juncheng Dai,Zhibin Hu,Michael P.A. Davies,Michael W. Marcus,Hans Brunnström,Jonas Manjer,Olle Melander,David C. Muller,Kim Overvad,Antonia Trichopoulou,Rosario Tumino,Jennifer A. Doherty,Jennifer A. Doherty,Gary E. Goodman,Angela Cox,Fiona Taylor,Penella J. Woll,Irene Brüske,Judith Manz,Thomas Muley,Angela Risch,Albert Rosenberger,Kjell Grankvist,Mikael Johansson,Frances A. Shepherd,Ming-Sound Tsao,Susanne M. Arnold,Eric B. Haura,Ciprian Bolca,Ivana Holcatova,V. Janout,Milica Kontic,Jolanta Lissowska,Anush Mukeria,Simona Ognjanovic,Tadeusz M Orlowski,Ghislaine Scelo,Beata Swiatkowska,David Zaridze,Per Bakke,Vidar Skaug,Shanbeh Zienolddiny,Eric J. Duell,Lesley M. Butler,Woon-Puay Koh,Yu-Tang Gao,Richard S. Houlston,John McLaughlin,Victoria L. Stevens,David C. Nickle,Ma'en Obeidat,Wim Timens,Bin Zhu,Lei Song,María Soler Artigas,María Soler Artigas,Martin D. Tobin,Martin D. Tobin,Louise V. Wain,Louise V. Wain,Fangyi Gu,Jinyoung Byun,Ahsan Kamal,Dakai Zhu,Rachel F. Tyndale,Rachel F. Tyndale,Wei-Qi Wei,Stephen J. Chanock,Paul Brennan,Christopher I. Amos,Christopher I. Amos +133 more
TL;DR: Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk, and provide important insights for the etiology of lung cancer.
Journal ArticleDOI
Causal relationships between body mass index, smoking and lung cancer: Univariable and multivariable Mendelian randomization
Wen Zhou,Wen Zhou,Geoffrey Liu,Rayjean J. Hung,Rayjean J. Hung,Philip C Haycock,Melinda C. Aldrich,Angeline S. Andrew,Susanne M. Arnold,Heike Bickeböller,Stig E. Bojesen,Paul Brennan,Hans Brunnström,Olle Melander,Neil E. Caporaso,Maria Teresa Landi,Chu Chen,Gary E. Goodman,David C. Christiani,Angela Cox,John K. Field,Mikael Johansson,Lambertus A. Kiemeney,Stephen Lam,Philip Lazarus,Loic Le Marchand,Gad Rennert,Angela Risch,Matthew B. Schabath,Sanjay Shete,Adonina Tardón,Shanbeh Zienolddiny,Hongbing Shen,Christopher I. Amos +33 more
TL;DR: The results highlight the histology‐specific impact of BMI on lung carcinogenesis and imply mediator role of smoking behaviors in the association between BMI and lung cancer.