S
Stephen J. O'Brien
Researcher at Saint Petersburg State University of Information Technologies, Mechanics and Optics
Publications - 1074
Citations - 98793
Stephen J. O'Brien is an academic researcher from Saint Petersburg State University of Information Technologies, Mechanics and Optics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 153, co-authored 1062 publications receiving 93025 citations. Previous affiliations of Stephen J. O'Brien include University College Cork & QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
Mammalian Keratin Associated Proteins (KRTAPs) Subgenomes: Disentangling Hair Diversity and Adaptation to Terrestrial and Aquatic Environments
Imran Khan,Emanuel Maldonado,Vitor Vasconcelos,Stephen J. O'Brien,Stephen J. O'Brien,Warren E. Johnson,Agostinho Antunes +6 more
TL;DR: Differences in KRTAP gene repertoire and gene expression, together with distinct rates of gene conversion/recombination, pseudogenization and positive selection, are likely responsible for micro and macro-phenotypic hair diversification among mammals in response to adaptations to ecological pressures.
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Considering genetic profiles in functional studies of immune responsiveness to HIV-1.
TL;DR: Here, an approach is proposed for assessing overall genetic risk on an individual basis and it is suggested that this information be considered when selecting comparison groups in studies of immune responses to HIV and/or in the interpretation of data derived from such studies.
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Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth.
Katja Seipel,Quintus G. Medley,Nancy Kedersha,Xin Zhang,Stephen J. O'Brien,Carles Serra-Pagès,Martin E. Hemler,Michel Streuli +7 more
TL;DR: Findings support a role for Trio as a multifunctional protein that integrates and amplifies signals involved in coordinating actin remodeling, which is necessary for cell migration and growth.
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How the Leopard Hides Its Spots: ASIP Mutations and Melanism in Wild Cats
Alexsandra Schneider,Victor A. David,Warren E. Johnson,Stephen J. O'Brien,Gregory S. Barsh,Marilyn Menotti-Raymond,Eduardo Eizirik +6 more
TL;DR: In this article, the coding region of the Agouti Signaling Protein (ASIP) gene in multiple leopard and Asian golden cat individuals was sequenced and identified distinct mutations strongly associated with melanism in each of them.
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Pandas, people and policy
TL;DR: Panda conservation in China has been plagued by controversy and cultural and political differences, but international cooperation, together with new studies identifying the main threats, offer renewed hope for the species' survival.