S
Stephen J. O'Brien
Researcher at Saint Petersburg State University of Information Technologies, Mechanics and Optics
Publications - 1074
Citations - 98793
Stephen J. O'Brien is an academic researcher from Saint Petersburg State University of Information Technologies, Mechanics and Optics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 153, co-authored 1062 publications receiving 93025 citations. Previous affiliations of Stephen J. O'Brien include University College Cork & QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
Dating the Origin of the CCR5-Δ32 AIDS-Resistance Allele by the Coalescence of Haplotypes
J. Claiborne Stephens,David Reich,David Goldstein,Hyoung Doo Shin,Michael W. Smith,Mary Carrington,Cheryl A. Winkler,Gavin A. Huttley,Rando Allikmets,Lynn M. Schriml,Bernard Gerrard,Michael Malasky,Maria D. Ramos,Susanne Morlot,Maria Tzetis,Carole Oddoux,Francesco S. di Giovine,Georgios Nasioulas,David Chandler,Michael Aseev,Matthew Hanson,Luba Kalaydjieva,Damjan Glavač,Paolo Gasparini,Emmanuel Kanavakis,Mireille Claustres,Marios Kambouris,Harry Ostrer,Gordon W. Duff,Vladislav S Baranov,Hiljar Sibul,Andres Metspalu,David Goldman,Nicholas G. Martin,David L. Duffy,Jörg Schmidtke,Xavier Estivill,Stephen J. O'Brien,Michael Dean +38 more
TL;DR: The geographic cline of CCR5-Delta32 frequencies and its recent emergence are consistent with a historic strong selective event, driving its frequency upward in ancestral Caucasian populations.
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Reconstruction of the chronically insufficient anterior cruciate ligament with the central third of the patellar ligament.
TL;DR: It is thought that major associated ligamentous instability predisposes the reconstruction to failure and should be corrected in conjunction with the reconstruction.
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Interactive influence of infectious disease and genetic diversity in natural populations.
TL;DR: The critical importance of maintaining genetic diversity with respect to disease defense genes in natural populations is indicated by certain populations which have reduced genetic variability and apparent increased vulnerability to infectious disease.
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Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS.
Xiaojiang Gao,George W. Nelson,Peter Karacki,Maureen P. Martin,John P. Phair,Richard A. Kaslow,James J. Goedert,Susan Buchbinder,Keith Hoots,David Vlahov,Stephen J. O'Brien,Mary Carrington,Mary Carrington +12 more
TL;DR: This analysis shows that, in patients with HIV-1 infection, a single amino acid change in HLA molecules has a substantial effect on the rate of progression to AIDS.
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The Multidomain Protein Trio Binds the LAR Transmembrane Tyrosine Phosphatase, Contains a Protein Kinase Domain, and Has Separate Rac-Specific and Rho-Specific Guanine Nucleotide Exchange Factor Domains
Anne Debant,Carles Serra-Pagès,Katja Seipel,Stephen J. O'Brien,May Tang,Sang-Ho Park,Michel Streuli +6 more
TL;DR: As the LAR PTPase localizes to the ends of focal adhesions, it is proposed that LAR and the Trio GEF/PSK may orchestrate cell-matrix and cytoskeletal rearrangements necessary for cell migration.