S
Stephen J. O'Brien
Researcher at Saint Petersburg State University of Information Technologies, Mechanics and Optics
Publications - 1074
Citations - 98793
Stephen J. O'Brien is an academic researcher from Saint Petersburg State University of Information Technologies, Mechanics and Optics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 153, co-authored 1062 publications receiving 93025 citations. Previous affiliations of Stephen J. O'Brien include University College Cork & QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
The Predictive Value of Early Molecular Response in Chronic Phase CML Patients Treated with Dasatinib First Line Therapy
David Marin,Corinne Hedgley,Richard E. Clark,Jane F. Apperley,Letizia Foroni,Dragana Milojkovic,Christopher Pocock,John M. Goldman,Stephen J. O'Brien +8 more
TL;DR: The key finding from this analysis is that patients who achieve a transcript level ≤10% after 3 months of dasatinib therapy on the 2 years CI of cytogenetic and molecular responses will have a significantly better 2 year CI of CCyR.
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Avian Binocularity and Adaptation to Nocturnal Environments: Genomic Insights from a Highly Derived Visual Phenotype
Rui Borges,João Fonseca,Cidália Gomes,Warren E. Johnson,Warren E. Johnson,Stephen J. O'Brien,Stephen J. O'Brien,Guojie Zhang,Guojie Zhang,M. Thomas P. Gilbert,Erich D. Jarvis,Erich D. Jarvis,Agostinho Antunes +12 more
TL;DR: This study disentangles the genomic changes governing the binocularity and low-light perception adaptations of barn owls to nocturnal environments while revealing the molecular mechanisms contributing to the shift from the typical avian photopic vision to the more-novel scotopic-adapted eye.
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Putting Russia on the genome map.
TL;DR: In the News story “Who has your DNA—or wants it” (25 September, p.1475), J. Kaiser listed 17 projects that aim to chart human genetic diversity across the globe in the context of a dozen ongoing national genome sequencing initiatives, yet Russia—a country with 1/10th of the population—isn’t among them.
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Giant panda paternity
Stephen J. O'Brien,David Goldman,John Knight,H. D. M. Moore,David E. Wildt,Mitchell Bush,Richard J. Montali,Devra G. Kleiman +7 more
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Primary cultures of human colon cancer as a model to study cancer stem cells.
S. A. Koshkin,Anna Danilova,Grigory Raskin,N. S. Petrov,Olga Bajenova,Stephen J. O'Brien,Alexey Tomilin,E. N. Tolkunova +7 more
TL;DR: The data shows the role of stem cell marker Oct4 in the resistance of primary colorectal cancer tumor cells to 5-fluorouracil and the ability of cells to form tumors in mice.