S
Stephen J. O'Brien
Researcher at Saint Petersburg State University of Information Technologies, Mechanics and Optics
Publications - 1074
Citations - 98793
Stephen J. O'Brien is an academic researcher from Saint Petersburg State University of Information Technologies, Mechanics and Optics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 153, co-authored 1062 publications receiving 93025 citations. Previous affiliations of Stephen J. O'Brien include University College Cork & QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
Racial Differences in HLA Class II Associations with Hepatitis C Virus Outcomes
Chloe L. Thio,David L. Thomas,James J. Goedert,David Vlahov,David Vlahov,Kenrad E. Nelson,Margaret W. Hilgartner,Stephen J. O'Brien,Peter Karacki,Darlene Marti,Jacquie Astemborski,Mary Carrington +11 more
TL;DR: A role for class II alleles in the immune response to HCV is supported and the importance of studying genetic associations in an ethnically diverse cohort is underscored.
Journal ArticleDOI
A molecular solution to the riddle of the giant panda's phylogeny
TL;DR: The apparently dramatic, but actually limited, distinctions between the giant panda and the bears in chromosomal and anatomical morphology provide a graphic mammalian example of the discordance of molecular and morphological (and chromosomal) evolutionary change
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A Family Matter: Conclusive Resolution of the Taxonomic Position of the Long-Fingered Bats, Miniopterus
Cassandra M. Miller-Butterworth,William J. Murphy,Stephen J. O'Brien,David S. Jacobs,Mark S. Springer,Emma C. Teeling +5 more
TL;DR: The authors' data confirm the distinctiveness of Miniopterus, and support previous recommendations to elevate these bats to full familial status, and estimate that they diverged from all other bat species approximately 49-38 MYA, which is comparable to most other bat families.
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A Scan for Linkage Disequilibrium Across the Human Genome
TL;DR: Although the spatial heterogeneity of LD the authors detect in Europeans is consistent with the operation of natural selection, absence of a formal test for such genomic scale data prevents eliminating neutral processes as the evolutionary origin of the LD.
Journal Article
The Case for Selection at CCR5-Δ32
Pardis C. Sabeti,Emily C. Walsh,Stephen F. Schaffner,Patrick Varilly,Ben Fry,Holli B. Hutcheson,Mike Cullen,Tarjei S. Mikkelsen,Jessica Roy,Nick Patterson,Richard Cooper,David Reich,David Altshuler,Stephen J. O'Brien,Eric S. Lander +14 more
TL;DR: The authors showed that the pattern of genetic variation at C-C chemokine receptor 5, 32 base-pair deletion (CCR5-D32) does not stand out as exceptional relative to other loci across the genome.