S
Stephen J. O'Brien
Researcher at Saint Petersburg State University of Information Technologies, Mechanics and Optics
Publications - 1074
Citations - 98793
Stephen J. O'Brien is an academic researcher from Saint Petersburg State University of Information Technologies, Mechanics and Optics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 153, co-authored 1062 publications receiving 93025 citations. Previous affiliations of Stephen J. O'Brien include University College Cork & QIMR Berghofer Medical Research Institute.
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Comparison of carnivore, omnivore, and herbivore mammalian genomes with a new leopard assembly
Soonok Kim,Yun Sung Cho,Yun Sung Cho,Hak-Min Kim,Oksung Chung,Hyunho Kim,Sungwoong Jho,Hong Seomun,Jeong-Ho Kim,Woo Young Bang,Changmu Kim,Junghwa An,Chang Hwan Bae,Youngjune Bhak,Sungwon Jeon,Hyejun Yoon,Yumi Kim,JeHoon Jun,Hye Jin Lee,Suan Cho,Olga Uphyrkina,Aleksey V. Kostyria,John M. Goodrich,Dale G. Miquelle,Dale G. Miquelle,Melody E. Roelke,John G. Lewis,Andrey A. Yurchenko,Anton Bankevich,Juok Cho,Semin Lee,Semin Lee,Jeremy S. Edwards,Jessica A. Weber,Jo Cook,Sangsoo Kim,Hang Lee,Andrea Manica,Ilbeum Lee,Stephen J. O'Brien,Stephen J. O'Brien,Jong Bhak,Joo-Hong Yeo +42 more
TL;DR: This study provides a large-scale family level comparative genomic analysis to address genomic changes associated with dietary specialization in carnivores, felids, and omnivores, indicating that carnivores are under strong selective pressure related to diet.
Journal ArticleDOI
Inter-species hybridization among Neotropical cats of the genus Leopardus, and evidence for an introgressive hybrid zone between L. geoffroyi and L. tigrinus in southern Brazil.
Tatiane Campos Trigo,Thales Renato Ochotorena de Freitas,G. Kunzler,L. Cardoso,J. C. R. Silva,Warren E. Johnson,Stephen J. O'Brien,Sandro L. Bonatto,Eduardo Eizirik,Eduardo Eizirik +9 more
TL;DR: This study employs mitochondrial DNA sequences and nine microsatellite loci to identify and characterize a hybrid zone between two Neotropical felids, Leopardus geoffroyi and L. tigrinus, and presents strong evidence for the occurrence of hybridization between these species.
Journal ArticleDOI
State of cat genomics
Stephen J. O'Brien,Warren E. Johnson,Carlos A. Driscoll,Joan Pontius,Jill Pecon-Slattery,Marilyn Menotti-Raymond +5 more
TL;DR: As the genome resources develop, the cat is poised to make a major contribution to many areas in genetics and biology.
Journal ArticleDOI
Evolution of CRISPs Associated with Toxicoferan-Reptilian Venom and Mammalian Reproduction
Kartik Sunagar,Warren E. Johnson,Stephen J. O'Brien,Stephen J. O'Brien,Vitor Vasconcelos,Agostinho Antunes +5 more
TL;DR: The use of ancestral sequence reconstruction, mapping of mutations on the three-dimensional structure, and detailed evaluation of selection pressures suggests that the toxicoferan CRISPs underwent accelerated evolution aided by strong positive selection and directional mutagenesis, whereas their mammalian homologs are constrained by negative selection.
Journal Article
Polymorphic admixture typing in human ethnic populations.
Michael Dean,J. Claiborne Stephens,Cheryl A. Winkler,Deborah A. Lomb,Mark Ramsburg,Raleigh Boaze,Claudia Stewart,Lauren Charbonneau,David Goldman,Bernard Albaugh,James J. Goedert,R. Palmer Beasley,Lu-Yu Hwang,Susan Buchbinder,Michael Weedon,Patricia A. Johnson,Mary Eichelberger,Stephen J. O'Brien +17 more
TL;DR: A panel of 257 RFLP loci was selected on the basis of high heterozygosity in Caucasian DNA surveys and equivalent spacing throughout the human genome to identify loci with high delta values between recently admixed populations of use in mapping by admixture linkage disequilibrium (MALD).