S
Stephen J. O'Brien
Researcher at Saint Petersburg State University of Information Technologies, Mechanics and Optics
Publications - 1074
Citations - 98793
Stephen J. O'Brien is an academic researcher from Saint Petersburg State University of Information Technologies, Mechanics and Optics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 153, co-authored 1062 publications receiving 93025 citations. Previous affiliations of Stephen J. O'Brien include University College Cork & QIMR Berghofer Medical Research Institute.
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Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps.
TL;DR: Genomic distances between species, dominated by inversions (reversals) and translocations, are presented in a first multispecies attempt using ordered mapping data to reconstruct the evolutionary exchanges that preceded modern placental mammal genomes.
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Evolution of gene regulation in ruminants differs between evolutionary breakpoint regions and homologous synteny blocks
Marta Farré,Jaebum Kim,Anastasia A. Proskuryakova,Yang Zhang,Anastasia I. Kulemzina,Qiye Li,Yang Zhou,Yingqi Xiong,Jennifer L. Johnson,Polina L. Perelman,Warren E. Johnson,Wesley C. Warren,Anna V. Kukekova,Guojie Zhang,Guojie Zhang,Stephen J. O'Brien,Oliver A. Ryder,Alexander S. Graphodatsky,Jian Ma,Harris A. Lewin,Denis M. Larkin,Denis M. Larkin +21 more
TL;DR: This work demonstrated that lineage-specific regulatory elements colocalized with gross chromosome rearrangements may have provided valuable functional modifications that helped to shape ruminant evolution.
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Clinically Relevant Anatomy and Biomechanics of the Proximal Biceps.
TL;DR: A more comprehensive understanding of the anatomy, pathoanatomy, and functional implications of the biceps-labral complex is embraced and clinicians can proceed with greater confidence and can more accurately select patient-specific surgical techniques.
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FIV diversity: FIVPle subtype composition may influence disease outcome in African lions
Jennifer L. Troyer,Melody E. Roelke,Jillian M. Jespersen,Natalie Baggett,Natalie Baggett,Valerie A. Buckley-Beason,Daniel R. MacNulty,Daniel R. MacNulty,Meggan E. Craft,Craig Packer,Jill Pecon-Slattery,Stephen J. O'Brien +11 more
TL;DR: In the Serengeti National Park, Tanzania, three divergent subtypes of lion FIV (FIVPle) are endemic, whereby 100% of adult lions are infected with one or more of these strains.
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Evolutionary Genomics and Adaptive Evolution of the Hedgehog Gene Family ( Shh, Ihh and Dhh ) in Vertebrates
Joana Pereira,Warren E. Johnson,Stephen J. O'Brien,Stephen J. O'Brien,Erich D. Jarvis,Guojie Zhang,M. Thomas P. Gilbert,Vitor Vasconcelos,Agostinho Antunes +8 more
TL;DR: Comparative genomic and adaptive evolutionary analyses are used to characterize the evolution of the Hh genes in vertebrates following the two major whole genome duplication (WGD) events and suggest that vertebrate Hh paralogous genes evolved independently within similar linkage groups and under different evolutionary rates, especially within the catalytic domain.