S
Stephen J. O'Brien
Researcher at Saint Petersburg State University of Information Technologies, Mechanics and Optics
Publications - 1074
Citations - 98793
Stephen J. O'Brien is an academic researcher from Saint Petersburg State University of Information Technologies, Mechanics and Optics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 153, co-authored 1062 publications receiving 93025 citations. Previous affiliations of Stephen J. O'Brien include University College Cork & QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
Five-year clinical and radiological outcomes in 257 consecutive cementless Oxford medial unicompartmental knee arthroplasties
TL;DR: The proportion of patients requiring revision at five years is lower than that generally reported for UKA, adding support for the use of the cementless OUKA outside the design centre.
Journal ArticleDOI
Aldehyde dehydrogenase 1 (ALDH1) isoform expression and potential clinical implications in hepatocellular carcinoma.
Cheng Kun Yang,Xiang‑Kun Wang,Xi‑Wen Liao,Chuang Ye Han,Ting Dong Yu,Wei Qin,Guang Zhi Zhu,Hao Su,Long Yu,Xiao Guang Liu,Si Cong Lu,Zhiwei Chen,Zhen Liu,Ke Tuan Huang,Zhengtao Liu,Yu Liang,Jian Lu Huang,Kai Yin Xiao,Min Hao Peng,Cheryl Ann Winkle,Stephen J. O'Brien,Tao Peng +21 more
TL;DR: It was found that the ALDH1 isoform showed high aldehyde dehydrogenase activity, which was protective for HCCs with multiple nodules and high serum alpha–fetoprotein (AFP) level.
Journal ArticleDOI
Genomic Adaptations and Evolutionary History of the Extinct Scimitar-Toothed Cat, Homotherium latidens.
Ross Barnett,Michael V. Westbury,Marcela Sandoval-Velasco,Filipe G. Vieira,Sungwon Jeon,Grant D. Zazula,Michael D. Martin,Simon Y. W. Ho,Niklas Mather,Shyam Gopalakrishnan,Jazmín Ramos-Madrigal,Marc de Manuel,M. Lisandra Zepeda-Mendoza,M. Lisandra Zepeda-Mendoza,Agostinho Antunes,Aldo Carmona Baez,Binia De Cahsan,Greger Larson,Stephen J. O'Brien,Stephen J. O'Brien,Eduardo Eizirik,Warren E. Johnson,Warren E. Johnson,Warren E. Johnson,Klaus-Peter Koepfli,Andreas Wilting,Jörns Fickel,Jörns Fickel,Love Dalén,Eline D. Lorenzen,Tomas Marques-Bonet,Anders J. Hansen,Guojie Zhang,Guojie Zhang,Jong Bhak,Nobuyuki Yamaguchi,M. Thomas P. Gilbert,M. Thomas P. Gilbert +37 more
TL;DR: It is suggested that Homotherium may have been more abundant than the limited fossil record suggests, and relatively high levels of genetic diversity are uncovered, enhancing understanding of the evolution and ecology of this remarkable lineage.
Book ChapterDOI
Quantitative Cladistic Analyses of Chromosomal Banding Data Among Species in Three Orders of Mammals: Hominoid Primates, Felids and Arvicolid Rodents
TL;DR: Over the past two decades a number of technical advances have been made which have improved the resolving power of differential chromosome staining procedures, enabling the identification of homologous elements both within and between species.
Journal ArticleDOI
Nonpathogenic lion and puma lentiviruses impart resistance to superinfection by virulent feline immunodeficiency virus.
TL;DR: Cats previously infected with LLV or PLV were able to more effectively control FIV infection and resist its immunologic effects, despite the substantial genetic divergence between these lentiviruses-raising the possibility that superinfection may impart resistance to lentivirus infection by heightening innate immune mechanisms.