S
Stephen J. O'Brien
Researcher at Saint Petersburg State University of Information Technologies, Mechanics and Optics
Publications - 1074
Citations - 98793
Stephen J. O'Brien is an academic researcher from Saint Petersburg State University of Information Technologies, Mechanics and Optics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 153, co-authored 1062 publications receiving 93025 citations. Previous affiliations of Stephen J. O'Brien include University College Cork & QIMR Berghofer Medical Research Institute.
Papers
More filters
Journal ArticleDOI
The Genome 10K Project: A Way Forward
TL;DR: The status of known vertebrate genome projects, recommend standards for pronouncing a genome as sequenced or completed, and the present and future vision of the landscape of Genome 10K are provided.
Journal ArticleDOI
Genomic ancestry of the American puma (Puma concolor)
TL;DR: The marked uniformity of mtDNA and a reduction in microsatellite allele size expansion indicates that North American pumas derive from a recent (late Pleistocene circa 10,000 years ago) replacement and recolonization by a small number of founders who themselves originated from a centrum of puma genetic diversity in eastern South America.
Journal ArticleDOI
Report of the committee on comparative mapping
P. L. Pearson,T. H. Roderick,Muriel T. Davisson,J.J. Garver,Dorothy Warburton,P. A. Lalley,Stephen J. O'Brien +6 more
Journal ArticleDOI
Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10.
Hyoung Doo Shin,Cheryl A. Winkler,J. Claiborne Stephens,Jay H. Bream,Howard A. Young,James J. Goedert,Thomas R. O'Brien,David Vlahov,Susan Buchbinder,Janis V. Giorgi,Charles R. Rinaldo,Sharyne Donfield,Anne Willoughby,Stephen J. O'Brien,Michael W. Smith +14 more
TL;DR: Alternative IL10 promoter alleles are functionally distinct in relative IL10 production, in retention of an avian erythroblastosis virus transcription factor recognition sequence and in binding to specific putative nuclear transcription factors, suggesting a potential mechanism whereby IL10-5'A down-regulation of inhibitory IL10 facilitates HIV-1 replication in vivo, accelerating the onset of AIDS.
Journal ArticleDOI
Accounting for multiple comparisons in a genome-wide association study (GWAS)
Randall C. Johnson,Randall C. Johnson,George W. Nelson,Jennifer L. Troyer,James A. Lautenberger,Bailey Kessing,Cheryl A. Winkler,Stephen J. O'Brien +7 more
TL;DR: Correcting for the number of LD blocks resulted in an anti-conservative Bonferroni adjustment, and SLIDE and simpleℳ are particularly useful when using a statistical test not handled in optimized permutation testing packages, and genome-wide corrected p-values using SLIDE, are much easier to interpret for consumers of GWAS studies.