Takashi Saito

TL;DR: Oral inoculation of Clostridium during the early life of conventionally reared mice resulted in resistance to colitis and systemic immunoglobulin E responses in adult mice, suggesting a new therapeutic approach to autoimmunity and allergy.

TL;DR: The ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes as mentioned in this paper, which is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100GeV and above 100 TeV.

TL;DR: The medium chains of two clathrin-associated protein complexes specifically interacted with tyrosine-based signals of several integral membrane proteins, and it is likely that the medium chains serve as signal-binding components of the clathin-dependent sorting machinery.

TL;DR: It is shown that FcγRs have two additional specific attributes in murine DCs: the induction of DC maturation and the promotion of efficient MHC class I–restricted presentation of peptides from exogenous, IgG-complexed antigens.

TL;DR: It is proposed that T CR signaling is sustained by stabilized microclusters and is terminated in the cSMAC, a structure from which TCR are sorted for degradation, and a role for F-actin in TCR signaling beyond microcluster formation is revealed.