California Institute of Technology

About: California Institute of Technology is a education organization based out in Pasadena, California, United States. It is known for research contribution in the topics: Galaxy & Redshift. The organization has 57649 authors who have published 146691 publications receiving 8620287 citations. The organization is also known as: Caltech & Cal Tech.

Cyclodextrin-based pharmaceutics: past, present and future

Abstract: Cyclodextrins are cyclic oligomers of glucose that can form water-soluble inclusion complexes with small molecules and portions of large compounds. These biocompatible, cyclic oligosaccharides do not elicit immune responses and have low toxicities in animals and humans. Cyclodextrins are used in pharmaceutical applications for numerous purposes, including improving the bioavailability of drugs. Current cyclodextrin-based therapeutics are described and possible future applications discussed. Cyclodextrin-containing polymers are reviewed and their use in drug delivery presented. Of specific interest is the use of cyclodextrin-containing polymers to provide unique capabilities for the delivery of nucleic acids.

Plasmonics—A Route to Nanoscale Optical Devices

Abstract: The further integration of optical devices will require the fabrication of waveguides for electromagnetic energy below the diffraction limit of light. We investigate the possibility of using arrays of closely spaced metal nanoparticles for this purpose. Coupling between adjacent particles sets up coupled plasmon modes that give rise to coherent propagation of energy along the array. A point dipole analysis predicts group velocities of energy transport that exceed 0.1c along straight arrays and shows that energy transmission and switching through chain networks such as corners (see Figure) and tee structures is possible at high efficiencies. Radiation losses into the far field are expected to be negligible due to the near-field nature of the coupling, and resistive heating leads to transmission losses of about 6 dB/lm for gold and silver particles. We analyze macroscopic analogues operating in the microwave regime consisting of closely spaced metal rods by experiments and full field electrodynamic simulations. The guiding structures show a high confinement of the electromagnetic energy and allow for highly variable geometries and switching. Also, we have fabricated gold nanoparticle arrays using electron beam lithography and atomic force microscopy manipulation. These plasmon waveguides and switches could be the smallest devices with optical functionality.

Cosmic-Ray Rejection by Laplacian Edge Detection

Abstract: Conventional algorithms for rejecting cosmic rays in single CCD exposures rely on the contrast between cosmic rays and their surroundings and may produce erroneous results if the point-spread function is smaller than the largest cosmic rays. This paper describes a robust algorithm for cosmic-ray rejection, based on a variation of Laplacian edge detection. The algorithm identifies cosmic rays of arbitrary shapes and sizes by the sharpness of their edges and reliably discriminates between poorly sampled point sources and cosmic rays. Examples of its performance are given for spectroscopic and imaging data, including Hubble Space Telescope Wide Field Planetary Camera 2 images.

Understanding Intelligence

Abstract: From the Publisher: Researchers now agree that intelligence always manifests itself in behavior - thus it is behavior that we must understand. An exciting new field has grown around the study of behavior-based intelligence, also known as embodied cognitive science, "new AI," and "behavior-based AI.". "Rolf Pfeifer and Christian Scheier provide a systematic introduction to this new way of thinking about intelligence and computers. After discussing concepts and approaches such as subsumption architecture, Braitenberg vehicles, evolutionary robotics, artificial life, self-organization, and learning, the authors derive a set of principles and a coherent framework for the study of naturally and artificially intelligent systems, or autonomous agents. This framework is based on a synthetic methodology whose goal is understanding by designing and building.

Spectral Energy Distributions of T Tauri Stars with Passive Circumstellar Disks

Abstract: We derive hydrostatic, radiative equilibrium models for passive disks surrounding T Tauri stars. Each disk is encased by an optically thin layer of superheated dust grains. This layer reemits directly to space about half the stellar energy it absorbs. The other half is emitted inward and regulates the interior temperature of the disk. The heated disk flares. As a consequence, it absorbs more stellar radiation, especially at large radii, than a flat disk would. The portion of the spectral energy distribution contributed by the disk is fairly flat throughout the thermal infrared. At fixed frequency, the contribution from the surface layer exceeds that from the interior by about a factor 3 and is emitted at more than an order of magnitude greater radius. Spectral features from dust grains in the superheated layer appear in emission if the disk is viewed nearly face-on.