Institution
California Institute of Technology
Education•Pasadena, California, United States•
About: California Institute of Technology is a education organization based out in Pasadena, California, United States. It is known for research contribution in the topics: Galaxy & Redshift. The organization has 57649 authors who have published 146691 publications receiving 8620287 citations. The organization is also known as: Caltech & Cal Tech.
Topics: Galaxy, Redshift, Population, Star formation, Stars
Papers published on a yearly basis
Papers
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TL;DR: This work demonstrates the creation of structural metamaterials composed of nanoscale ceramics that are simultaneously ultralight, strong, and energy-absorbing and can recover their original shape after compressions in excess of 50% strain.
Abstract: Ceramics have some of the highest strength- and stiffness-to-weight ratios of any material but are suboptimal for use as structural materials because of their brittleness and sensitivity to flaws. We demonstrate the creation of structural metamaterials composed of nanoscale ceramics that are simultaneously ultralight, strong, and energy-absorbing and can recover their original shape after compressions in excess of 50% strain. Hollow-tube alumina nanolattices were fabricated using two-photon lithography, atomic layer deposition, and oxygen plasma etching. Structures were made with wall thicknesses of 5 to 60 nanometers and densities of 6.3 to 258 kilograms per cubic meter. Compression experiments revealed that optimizing the wall thickness-to-radius ratio of the tubes can suppress brittle fracture in the constituent solid in favor of elastic shell buckling, resulting in ductile-like deformation and recoverability.
1,044 citations
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TL;DR: The results offer the promise of in vivo mapping of gene expression in transgenic animals and validate a general approach for constructing a family of MRI contrast agents that respond to biological activity.
Abstract: High-resolution in vivo imaging of gene expression is not possible in opaque animals by existing techniques. Here we present a new approach for obtaining such images by magnetic resonance imaging (MRI) using an MRI contrast agent that can indicate reporter gene expression in living animals. We have prepared MRI contrast agents in which the access of water to the first coordination sphere of a chelated paramagnetic ion is blocked with a substrate that can be removed by enzymatic cleavage. Following cleavage, the paramagnetic ion can interact directly with water protons to increase the MR signal. Here, we report an agent where galactopyranose is the blocking group. This group renders the MRI contrast agent sensitive to expression of the commonly used marker gene, β-galactosidase. To cellular resolution, regions of higher intensity in the MR image correlate with regions expressing marker enzyme. These results offer the promise of in vivo mapping of gene expression in transgenic animals and validate a general approach for constructing a family of MRI contrast agents that respond to biological activity.
1,043 citations
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TL;DR: In this paper, the accuracy of global-gridded terrestrial water storage (TWS) estimates derived from temporal gravity field variations observed by the Gravity Recovery and Climate Experiment (GRACE) satellites is assessed.
Abstract: [1] We assess the accuracy of global-gridded terrestrial water storage (TWS) estimates derived from temporal gravity field variations observed by the Gravity Recovery and Climate Experiment (GRACE) satellites. The TWS data set has been corrected for signal modification due to filtering and truncation. Simulations of terrestrial water storage variations from land-hydrology models are used to infer relationships between regional time series representing different spatial scales. These relationships, which are independent of the actual GRACE data, are used to extrapolate the GRACE TWS estimates from their effective spatial resolution (length scales of a few hundred kilometers) to finer spatial scales (∼100 km). Gridded, scaled data like these enable users who lack expertise in processing and filtering the standard GRACE spherical harmonic geopotential coefficients to estimate the time series of TWS over arbitrarily shaped regions. In addition, we provide gridded fields of leakage and GRACE measurement errors that allow users to rigorously estimate the associated regional TWS uncertainties. These fields are available for download from the GRACE project website (available at http://grace.jpl.nasa.gov). Three scaling relationships are examined: a single gain factor based on regionally averaged time series, spatially distributed (i.e., gridded) gain factors based on time series at each grid point, and gridded-gain factors estimated as a function of temporal frequency. While regional gain factors have typically been used in previously published studies, we find that comparable accuracies can be obtained from scaled time series based on gridded gain factors. In regions where different temporal modes of TWS variability have significantly different spatial scales, gain factors based on the first two methods may reduce the accuracy of the scaled time series. In these cases, gain factors estimated separately as a function of frequency may be necessary to achieve accurate results.
1,043 citations
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TL;DR: The capabilities and design philosophy of the current version of the PySCF package are document, which is as efficient as the best existing C or Fortran‐based quantum chemistry programs.
Abstract: Python-based simulations of chemistry framework (PySCF) is a general-purpose electronic structure platform designed from the ground up to emphasize code simplicity, so as to facilitate new method development and enable flexible computational workflows. The package provides a wide range of tools to support simulations of finite-size systems, extended systems with periodic boundary conditions, low-dimensional periodic systems, and custom Hamiltonians, using mean-field and post-mean-field methods with standard Gaussian basis functions. To ensure ease of extensibility, PySCF uses the Python language to implement almost all of its features, while computationally critical paths are implemented with heavily optimized C routines. Using this combined Python/C implementation, the package is as efficient as the best existing C or Fortran-based quantum chemistry programs. In this paper, we document the capabilities and design philosophy of the current version of the PySCF package. WIREs Comput Mol Sci 2018, 8:e1340. doi: 10.1002/wcms.1340
This article is categorized under:
Structure and Mechanism > Computational Materials Science
Electronic Structure Theory > Ab Initio Electronic Structure Methods
Software > Quantum Chemistry
1,042 citations
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TL;DR: The formation of vortex rings generated through impulsively started jets is studied experimentally in this paper, where the velocity and vorticity field of the leading vortex ring formed is disconnected from that of the trailing jet.
Abstract: The formation of vortex rings generated through impulsively started jets is studied experimentally. Utilizing a piston/cylinder arrangement in a water tank, the velocity and vorticity fields of vortex rings are obtained using digital particle image velocimetry (DPIV) for a wide range of piston stroke to diameter (L/D) ratios. The results indicate that the flow field generated by large L/D consists of a leading vortex ring followed by a trailing jet. The vorticity field of the leading vortex ring formed is disconnected from that of the trailing jet. On the other hand, flow fields generated by small stroke ratios show only a single vortex ring. The transition between these two distinct states is observed to occur at a stroke ratio of approximately 4, which, in this paper, is referred to as the ‘formation number’. In all cases, the maximum circulation that a vortex ring can attain during its formation is reached at this non-dimensional time or formation number. The universality of this number was tested by generating vortex rings with different jet exit diameters and boundaries, as well as with various non-impulsive piston velocities. It is shown that the ‘formation number’ lies in the range of 3.6–4.5 for a broad range of flow conditions. An explanation is provided for the existence of the formation number based on the Kelvin–Benjamin variational principle for steady axis-touching vortex rings. It is shown that based on the measured impulse, circulation and energy of the observed vortex rings, the Kelvin–Benjamin principle correctly predicts the range of observed formation numbers.
1,042 citations
Authors
Showing all 58155 results
Name | H-index | Papers | Citations |
---|---|---|---|
Eric S. Lander | 301 | 826 | 525976 |
Donald P. Schneider | 242 | 1622 | 263641 |
George M. Whitesides | 240 | 1739 | 269833 |
Yi Chen | 217 | 4342 | 293080 |
David Baltimore | 203 | 876 | 162955 |
Edward Witten | 202 | 602 | 204199 |
George Efstathiou | 187 | 637 | 156228 |
Michael A. Strauss | 185 | 1688 | 208506 |
Jing Wang | 184 | 4046 | 202769 |
Ruedi Aebersold | 182 | 879 | 141881 |
Douglas Scott | 178 | 1111 | 185229 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Phillip A. Sharp | 172 | 614 | 117126 |
Timothy M. Heckman | 170 | 754 | 141237 |
Zhenan Bao | 169 | 865 | 106571 |