Institution
California Institute of Technology
Education•Pasadena, California, United States•
About: California Institute of Technology is a education organization based out in Pasadena, California, United States. It is known for research contribution in the topics: Galaxy & Redshift. The organization has 57649 authors who have published 146691 publications receiving 8620287 citations. The organization is also known as: Caltech & Cal Tech.
Topics: Galaxy, Redshift, Population, Star formation, Stars
Papers published on a yearly basis
Papers
More filters
••
TL;DR: Measurements at room temperature in the analogous regime of electromagnetically induced absorption show the utility of these chip-scale optomechanical systems for optical buffering, amplification, and filtering of microwave-over-optical signals.
Abstract: Controlling the interaction between localized optical and mechanical excitations has recently become possible following advances in micro- and nanofabrication techniques. So far, most experimental studies of optomechanics have focused on measurement and control of the mechanical subsystem through its interaction with optics, and have led to the experimental demonstration of dynamical back-action cooling and optical rigidity of the mechanical system. Conversely, the optical response of these systems is also modified in the presence of mechanical interactions, leading to effects such as electromagnetically induced transparency (EIT) and parametric normal-mode splitting. In atomic systems, studies of slow and stopped light (applicable to modern optical networks and future quantum networks) have thrust EIT to the forefront of experimental study during the past two decades. Here we demonstrate EIT and tunable optical delays in a nanoscale optomechanical crystal, using the optomechanical nonlinearity to control the velocity of light by way of engineered photon-phonon interactions. Our device is fabricated by simply etching holes into a thin film of silicon. At low temperature (8.7 kelvin), we report an optically tunable delay of 50 nanoseconds with near-unity optical transparency, and superluminal light with a 1.4 microsecond signal advance. These results, while indicating significant progress towards an integrated quantum optomechanical memory, are also relevant to classical signal processing applications. Measurements at room temperature in the analogous regime of electromagnetically induced absorption show the utility of these chip-scale optomechanical systems for optical buffering, amplification, and filtering of microwave-over-optical signals.
1,208 citations
••
TL;DR: The first fully automated design and experimental validation of a novel sequence for an entire protein is described, and a BLAST search shows that the designed sequence, full sequence design 1 (FSD-1), has very low identity to any known protein sequence.
Abstract: The first fully automated design and experimental validation of a novel sequence for an entire protein is described. A computational design algorithm based on physical chemical potential functions and stereochemical constraints was used to screen a combinatorial library of 1.9 x 10^(27) possible amino acid sequences for compatibility with the design target, a ββα protein motif based on the polypeptide backbone structure of a zinc finger domain. A BLAST search shows that the designed sequence, full sequence design 1 (FSD-1), has very low identity to any known protein sequence. The solution structure of FSD-1 was solved by nuclear magnetic resonance spectroscopy and indicates that FSD-1 forms a compact well-ordered structure, which is in excellent agreement with the design target structure. This result demonstrates that computational methods can perform the immense combinatorial search required for protein design, and it suggests that an unbiased and quantitative algorithm can be used in various structural contexts.
1,208 citations
••
TL;DR: It is shown that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity.
1,205 citations
••
TL;DR: Using a multiround version of an economic exchange (trust game), it is reported that reciprocity expressed by one player strongly predicts future trust expressed by their partner—a behavioral finding mirrored by neural responses in the dorsal striatum that extends previous model-based functional magnetic resonance imaging studies into the social domain.
Abstract: Using a multiround version of an economic exchange (trust game), we report that reciprocity expressed by one player strongly predicts future trust expressed by their partner—a behavioral finding mirrored by neural responses in the dorsal striatum. Here, analyses within and between brains revealed two signals—one encoded by response magnitude, and the other by response timing. Response magnitude correlated with the “intention to trust” on the next play of the game, and the peak of these “intention to trust” responses shifted its time of occurrence by 14 seconds as player reputations developed. This temporal transfer resembles a similar shift of reward prediction errors common to reinforcement learning models, but in the context of a social exchange. These data extend previous model-based functional magnetic resonance imaging studies into the social domain and broaden our view of the spectrum of functions implemented by the dorsal striatum.
1,204 citations
••
Ames Research Center1, University of California, Berkeley2, San Jose State University3, Las Cumbres Observatory Global Telescope Network4, Aarhus University5, University of Texas at Austin6, Lowell Observatory7, California Institute of Technology8, Harvard University9, Space Telescope Science Institute10, Goddard Space Flight Center11, United States Department of the Navy12, Carnegie Institution for Science13, University of Washington14, York University15, University of Hawaii16, Marshall Space Flight Center17
TL;DR: The Kepler mission as mentioned in this paper was designed with the explicit capability to detect Earth-size planets in the habitable zone of solar-like stars using the transit photometry method, and the results from just 43 days of data along with ground-based follow-up observations have identified five new transiting planets with measurements of their masses, radii, and orbital periods.
Abstract: The Kepler Mission, launched on 2009 March 6, was designed with the explicit capability to detect Earth-size planets in the habitable zone of solar-like stars using the transit photometry method. Results from just 43 days of data along with ground-based follow-up observations have identified five new transiting planets with measurements of their masses, radii, and orbital periods. Many aspects of stellar astrophysics also benefit from the unique, precise, extended, and nearly continuous data set for a large number and variety of stars. Early results for classical variables and eclipsing stars show great promise. To fully understand the methodology, processes, and eventually the results from the mission, we present the underlying rationale that ultimately led to the flight and ground system designs used to achieve the exquisite photometric performance. As an example of the initial photometric results, we present variability measurements that can be used to distinguish dwarf stars from red giants.
1,203 citations
Authors
Showing all 58155 results
Name | H-index | Papers | Citations |
---|---|---|---|
Eric S. Lander | 301 | 826 | 525976 |
Donald P. Schneider | 242 | 1622 | 263641 |
George M. Whitesides | 240 | 1739 | 269833 |
Yi Chen | 217 | 4342 | 293080 |
David Baltimore | 203 | 876 | 162955 |
Edward Witten | 202 | 602 | 204199 |
George Efstathiou | 187 | 637 | 156228 |
Michael A. Strauss | 185 | 1688 | 208506 |
Jing Wang | 184 | 4046 | 202769 |
Ruedi Aebersold | 182 | 879 | 141881 |
Douglas Scott | 178 | 1111 | 185229 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Phillip A. Sharp | 172 | 614 | 117126 |
Timothy M. Heckman | 170 | 754 | 141237 |
Zhenan Bao | 169 | 865 | 106571 |