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Showing papers by "California Institute of Technology published in 2003"


Book
17 Mar 2003
TL;DR: The first substantial and authoritative effort to close this gap was made by Camerer, who used psychological principles and hundreds of experiments to develop mathematical theories of reciprocity, limited strategizing, and learning, which help predict what real people and companies do in strategic situations as discussed by the authors.
Abstract: Game theory, the formalized study of strategy, began in the 1940s by asking how emotionless geniuses should play games, but ignored until recently how average people with emotions and limited foresight actually play games. This book marks the first substantial and authoritative effort to close this gap. Colin Camerer, one of the field's leading figures, uses psychological principles and hundreds of experiments to develop mathematical theories of reciprocity, limited strategizing, and learning, which help predict what real people and companies do in strategic situations. Unifying a wealth of information from ongoing studies in strategic behavior, he takes the experimental science of behavioral economics a major step forward. He does so in lucid, friendly prose. Behavioral game theory has three ingredients that come clearly into focus in this book: mathematical theories of how moral obligation and vengeance affect the way people bargain and trust each other; a theory of how limits in the brain constrain the number of steps of "I think he thinks . . ." reasoning people naturally do; and a theory of how people learn from experience to make better strategic decisions. Strategic interactions that can be explained by behavioral game theory include bargaining, games of bluffing as in sports and poker, strikes, how conventions help coordinate a joint activity, price competition and patent races, and building up reputations for trustworthiness or ruthlessness in business or life. While there are many books on standard game theory that address the way ideally rational actors operate, Behavioral Game Theory stands alone in blending experimental evidence and psychology in a mathematical theory of normal strategic behavior. It is must reading for anyone who seeks a more complete understanding of strategic thinking, from professional economists to scholars and students of economics, management studies, psychology, political science, anthropology, and biology.

4,701 citations


Journal ArticleDOI
TL;DR: This work summarizes the Systems Biology Markup Language (SBML) Level 1, a free, open, XML-based format for representing biochemical reaction networks, a software-independent language for describing models common to research in many areas of computational biology.
Abstract: Motivation: Molecular biotechnology now makes it possible to build elaborate systems models, but the systems biology community needs information standards if models are to be shared, evaluated and developed cooperatively. Results: We summarize the Systems Biology Markup Language (SBML) Level 1, a free, open, XML-based format for representing biochemical reaction networks. SBML is a software-independent language for describing models common to research in many areas of computational biology, including cell signaling pathways, metabolic pathways, gene regulation, and others. ∗ To whom correspondence should be addressed. Availability: The specification of SBML Level 1 is freely available from http://www.sbml.org/.

3,205 citations


Journal ArticleDOI
TL;DR: The results establish a precise connection between concepts of quantum information, condensed matter physics, and quantum field theory, by showing that the behavior of critical entanglement in spin systems is analogous to that of entropy in conformal field theories.
Abstract: Entanglement, one of the most intriguing features of quantum theory and a main resource in quantum information science, is expected to play a crucial role also in the study of quantum phase transitions, where it is responsible for the appearance of long-range correlations. We investigate, through a microscopic calculation, the scaling properties of entanglement in spin chain systems, both near and at a quantum critical point. Our results establish a precise connection between concepts of quantum information, condensed matter physics, and quantum field theory, by showing that the behavior of critical entanglement in spin systems is analogous to that of entropy in conformal field theories. We explore some of the implications of this connection.

2,522 citations


Journal ArticleDOI
TL;DR: USNO-B is an all-sky catalog that presents positions, proper motions, magnitudes in various optical passbands, and star/galaxy estimators for 1,042,618,261 objects derived from 3,643,201,733 separate observations as mentioned in this paper.
Abstract: USNO-B is an all-sky catalog that presents positions, proper motions, magnitudes in various optical passbands, and star/galaxy estimators for 1,042,618,261 objects derived from 3,643,201,733 separate observations. The data were obtained from scans of 7435 Schmidt plates taken for the various sky surveys during the last 50 years. USNO-B1.0 is believed to provide all-sky coverage, completeness down to V = 21, 02 astrometric accuracy at J2000, 0.3 mag photometric accuracy in up to five colors, and 85% accuracy for distinguishing stars from nonstellar objects. A brief discussion of various issues is given here, but the actual data are available from the US Naval Observatory Web site and others.

2,502 citations


Proceedings ArticleDOI
18 Jun 2003
TL;DR: The flexible nature of the model is demonstrated by excellent results over a range of datasets including geometrically constrained classes (e.g. faces, cars) and flexible objects (such as animals).
Abstract: We present a method to learn and recognize object class models from unlabeled and unsegmented cluttered scenes in a scale invariant manner. Objects are modeled as flexible constellations of parts. A probabilistic representation is used for all aspects of the object: shape, appearance, occlusion and relative scale. An entropy-based feature detector is used to select regions and their scale within the image. In learning the parameters of the scale-invariant object model are estimated. This is done using expectation-maximization in a maximum-likelihood setting. In recognition, this model is used in a Bayesian manner to classify images. The flexible nature of the model is demonstrated by excellent results over a range of datasets including geometrically constrained classes (e.g. faces, cars) and flexible objects (such as animals).

2,411 citations


Journal ArticleDOI
TL;DR: Observations of electromagnetic energy transport from a localized subwavelength source to a localized detector over distances of about 0.5 μm in plasmon waveguides consisting of closely spaced silver rods are presented.
Abstract: Achieving control of light-material interactions for photonic device applications at nanoscale dimensions will require structures that guide electromagnetic energy with a lateral mode confinement below the diffraction limit of light. This cannot be achieved by using conventional waveguides or photonic crystals. It has been suggested that electromagnetic energy can be guided below the diffraction limit along chains of closely spaced metal nanoparticles that convert the optical mode into non-radiating surface plasmons. A variety of methods such as electron beam lithography and self-assembly have been used to construct metal nanoparticle plasmon waveguides. However, all investigations of the optical properties of these waveguides have so far been confined to collective excitations and direct experimental evidence for energy transport along plasmon waveguides has proved elusive. Here we present observations of electromagnetic energy transport from a localized subwavelength source to a localized detector over distances of about 0.5 μm in plasmon waveguides consisting of closely spaced silver rods. The waveguides are excited by the tip of a near-field scanning optical microscope, and energy transport is probed by using fluorescent nanospheres.

2,305 citations


PatentDOI
24 Sep 2003-Science
TL;DR: The fluidic multiplexor as discussed by the authors is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs.
Abstract: High-density microfluidic chips contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large scale integration (LSI). A component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. These integrated microfluidic networks can be used to construct a variety of highly complex microfluidic devices, for example the microfluidic analog of a comparator array, and a microfluidic memory storage device resembling electronic random access memories.

2,292 citations


Journal ArticleDOI
TL;DR: It is concluded that Mfn1 and Mfn2 have both redundant and distinct functions and act in three separate molecular complexes to promote mitochondrial fusion, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population.
Abstract: Mitochondrial morphology is determined by a dynamic equilibrium between organelle fusion and fission, but the significance of these processes in vertebrates is unknown. The mitofusins, Mfn1 and Mfn2, have been shown to affect mitochondrial morphology when overexpressed. We find that mice deficient in either Mfn1 or Mfn2 die in midgestation. However, whereas Mfn2 mutant embryos have a specific and severe disruption of the placental trophoblast giant cell layer, Mfn1-deficient giant cells are normal. Embryonic fibroblasts lacking Mfn1 or Mfn2 display distinct types of fragmented mitochondria, a phenotype we determine to be due to a severe reduction in mitochondrial fusion. Moreover, we find that Mfn1 and Mfn2 form homotypic and heterotypic complexes and show, by rescue of mutant cells, that the homotypic complexes are functional for fusion. We conclude that Mfn1 and Mfn2 have both redundant and distinct functions and act in three separate molecular complexes to promote mitochondrial fusion. Strikingly, a subset of mitochondria in mutant cells lose membrane potential. Therefore, mitochondrial fusion is essential for embryonic development, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population.

2,239 citations


Journal ArticleDOI
06 Jun 2003
TL;DR: This work demonstrates a process for producing silica toroid-shaped microresonators-on-a-chip with Q factors in excess of 100 million using a combination of lithography, dry etching and a selective reflow process, representing an improvement of nearly four orders of magnitude over previous chip-based resonators.
Abstract: We demonstrate microfabrication of ultra-high-Q microcavities on a chip, exhibiting a novel toroid-shaped geometry. The cavities possess Q-factors in excess of 100 million which constitutes an improvement close to 4 orders-of-magnitude in Q compared to previous work [B. Gayral, et al., 1999].

2,177 citations


Journal ArticleDOI
TL;DR: In this article, the authors explore the consequences that follow if the dark energy is phantom energy, in which the sum of the pressure and energy density is negative, and the positive phantom energy density becomes infinite in finite time, overcoming all other forms of matter, such that the gravitational repulsion rapidly brings our brief epoch of cosmic structure to a close.
Abstract: We explore the consequences that follow if the dark energy is phantom energy, in which the sum of the pressure and energy density is negative. The positive phantom-energy density becomes infinite in finite time, overcoming all other forms of matter, such that the gravitational repulsion rapidly brings our brief epoch of cosmic structure to a close. The phantom energy rips apart the Milky Way, solar system, Earth, and ultimately the molecules, atoms, nuclei, and nucleons of which we are composed, before the death of the Universe in a "big rip."

2,177 citations


Journal ArticleDOI
TL;DR: The sorption data indicate that, under most of the chemical conditions investigated in this study, reduction of As(V) in the presence of HFO or goethite would have only minor effects on or even decrease its mobility in the environment at near-neutral pH conditions.
Abstract: Arsenic derived from natural sources occurs in groundwater in many countries, affecting the health of millions of people. The combined effects of As(V) reduction and diagenesis of iron oxide minerals on arsenic mobility are investigated in this study by comparing As(V) and As(III) sorption onto amorphous iron oxide (HFO), goethite, and magnetite at varying solution compositions. Experimental data are modeled with a diffuse double layer surface complexation model, and the extracted model parameters are used to examine the consistency of our results with those previously reported. Sorption of As(V) onto HFO and goethite is more favorable than that of As(III) below pH 5−6, whereas, above pH 7−8, As(III) has a higher affinity for the solids. The pH at which As(V) and As(III) are equally sorbed depends on the solid-to-solution ratio and type and specific surface area of the minerals and is shifted to lower pH values in the presence of phosphate, which competes for sorption sites. The sorption data indicate tha...

Journal ArticleDOI
K. Eguchi1, Sanshiro Enomoto1, K. Furuno1, J. Goldman1, H. Hanada1, H. Ikeda, Kiyohiro Ikeda1, Kunio Inoue, K. Ishihara1, W. Itoh1, T. Iwamoto1, Tomoya Kawaguchi1, T. Kawashima1, H. Kinoshita1, Yasuhiro Kishimoto, M. Koga, Y. Koseki1, T. Maeda1, T. Mitsui, M. Motoki, K. Nakajima1, M. Nakajima1, T. Nakajima1, Hiroshi Ogawa1, K. Owada1, T. Sakabe1, I. Shimizu, J. Shirai1, F. Suekane, A. Suzuki1, K. Tada1, Osamu Tajima1, T. Takayama1, K. Tamae1, Hideki Watanabe, J. Busenitz2, Z. Djurcic2, K. McKinny2, Dongming Mei2, A. Piepke2, E. Yakushev2, B. E. Berger3, Y. D. Chan3, M. P. Decowski3, D. A. Dwyer3, Stuart J. Freedman3, Y. Fu3, B. K. Fujikawa3, K. M. Heeger3, K. T. Lesko3, K. B. Luk3, Hitoshi Murayama3, D. R. Nygren3, C. E. Okada3, A. W. P. Poon3, H. M. Steiner3, Lindley Winslow3, G. A. Horton-Smith4, R. D. McKeown4, J. Ritter4, B. Tipton4, Petr Vogel4, C. E. Lane5, T. Miletic5, Peter Gorham, G. Guillian, John G. Learned, J. Maricic, S. Matsuno, Sandip Pakvasa, S. Dazeley6, S. Hatakeyama6, M. Murakami6, R. Svoboda6, B. D. Dieterle7, M. DiMauro7, J. A. Detwiler8, Giorgio Gratta8, K. Ishii8, N. Tolich8, Y. Uchida8, M. Batygov9, W. M. Bugg9, H. O. Cohn9, Yuri Efremenko9, Yuri Kamyshkov9, A. Kozlov9, Y. Nakamura9, L. De Braeckeleer10, L. De Braeckeleer11, C. R. Gould11, C. R. Gould10, Hugon J Karwowski11, Hugon J Karwowski10, D. M. Markoff11, D. M. Markoff10, J. A. Messimore10, J. A. Messimore11, Koji Nakamura11, Koji Nakamura10, Ryan Rohm11, Ryan Rohm10, Werner Tornow11, Werner Tornow10, Albert Young11, Albert Young10, Y. F. Wang 
TL;DR: In the context of two-flavor neutrino oscillations with CPT invariance, all solutions to the solar neutrinos problem except for the "large mixing angle" region are excluded.
Abstract: KamLAND has measured the flux of ν _e’s from distant nuclear reactors. We find fewer ν _e events than expected from standard assumptions about ν _e propagation at the 99.95% C.L. In a 162 ton·yr exposure the ratio of the observed inverse β-decay events to the expected number without ν _e disappearance is 0.611±0.085(stat)±0.041(syst) for ν _e energies >3.4 MeV. In the context of two-flavor neutrino oscillations with CPT invariance, all solutions to the solar neutrino problem except for the “large mixing angle” region are excluded.

Journal ArticleDOI
TL;DR: Electrochemistry-based sensors offer sensitivity, selectivity and low cost for the detection of selected DNA sequences or mutated genes associated with human disease.
Abstract: Electrochemistry-based sensors offer sensitivity, selectivity and low cost for the detection of selected DNA sequences or mutated genes associated with human disease. DNA-based electrochemical sensors exploit a range of different chemistries, but all take advantage of nanoscale interactions between the target in solution, the recognition layer and a solid electrode surface. Numerous approaches to electrochemical detection have been developed, including direct electrochemistry of DNA, electrochemistry at polymer-modified electrodes, electrochemistry of DNA-specific redox reporters, electrochemical amplifications with nanoparticles, and electrochemical devices based on DNA-mediated charge transport chemistry.

Journal ArticleDOI
TL;DR: The results imply that a necessary condition for an exponential computational speedup is that the amount of entanglement increases with the size n of the computation, and provide an explicit lower bound on the required growth.
Abstract: We present a classical protocol to efficiently simulate any pure-state quantum computation that involves only a restricted amount of entanglement. More generally, we show how to classically simulate pure-state quantum computations on n qubits by using computational resources that grow linearly in n and exponentially in the amount of entanglement in the quantum computer. Our results imply that a necessary condition for an exponential computational speedup (with respect to classical computations) is that the amount of entanglement increases with the size n of the computation, and provide an explicit lower bound on the required growth.

Book ChapterDOI
01 Jan 2003
TL;DR: A unified and consistent set of flexible tools to approximate important geometric attributes, including normal vectors and curvatures on arbitrary triangle meshes, using averaging Voronoi cells and the mixed Finite-Element/Finite-Volume method is proposed.
Abstract: This paper proposes a unified and consistent set of flexible tools to approximate important geometric attributes, including normal vectors and curvatures on arbitrary triangle meshes. We present a consistent derivation of these first and second order differential properties using averaging Voronoi cells and the mixed Finite-Element/Finite-Volume method, and compare them to existing formulations. Building upon previous work in discrete geometry, these operators are closely related to the continuous case, guaranteeing an appropriate extension from the continuous to the discrete setting: they respect most intrinsic properties of the continuous differential operators. We show that these estimates are optimal in accuracy under mild smoothness conditions, and demonstrate their numerical quality. We also present applications of these operators, such as mesh smoothing, enhancement, and quality checking, and show results of denoising in higher dimensions, such as for tensor images.

Journal ArticleDOI
TL;DR: It is found that tumor-derived progenitors form neurospheres that can be passaged at clonal density and are able to self-renew, which may have important implications for treatment by means of specific targeting of stem-like cells within brain tumors.
Abstract: Pediatric brain tumors are significant causes of morbidity and mortality. It has been hypothesized that they derive from self-renewing multipotent neural stem cells. Here, we tested whether different pediatric brain tumors, including medulloblastomas and gliomas, contain cells with properties similar to neural stem cells. We find that tumor-derived progenitors form neurospheres that can be passaged at clonal density and are able to self-renew. Under conditions promoting differentiation, individual cells are multipotent, giving rise to both neurons and glia, in proportions that reflect the tumor of origin. Unlike normal neural stem cells, however, tumor-derived progenitors have an unusual capacity to proliferate and sometimes differentiate into abnormal cells with multiple differentiation markers. Gene expression analysis reveals that both whole tumors and tumor-derived neurospheres express many genes characteristic of neural and other stem cells, including CD133, Sox2, musashi-1, bmi-1, maternal embryonic leucine zipper kinase, and phosphoserine phosphatase, with variation from tumor to tumor. After grafting to neonatal rat brains, tumor-derived neurosphere cells migrate, produce neurons and glia, and continue to proliferate for more than 4 weeks. The results show that pediatric brain tumors contain neural stem-like cells with altered characteristics that may contribute to tumorigenesis. This finding may have important implications for treatment by means of specific targeting of stem-like cells within brain tumors.

Book
01 Jan 2003
TL;DR: Spacetime and Geometry as discussed by the authors is an introductory textbook on general relativity specifically aimed at students, which covers the foundations of the theory and mathematical formalism, providing an approachable introduction to what can often be an intimidating subject.
Abstract: Spacetime and Geometry is an introductory textbook on general relativity, specifically aimed at students. Using a lucid style, Carroll first covers the foundations of the theory and mathematical formalism, providing an approachable introduction to what can often be an intimidating subject. Three major applications of general relativity are then discussed: black holes, perturbation theory and gravitational waves, and cosmology. Students will learn the origin of how spacetime curves (the Einstein equation) and how matter moves through it (the geodesic equation). They will learn what black holes really are, how gravitational waves are generated and detected, and the modern view of the expansion of the universe. A brief introduction to quantum field theory in curved spacetime is also included. A student familiar with this book will be ready to tackle research-level problems in gravitational physics.

Journal ArticleDOI
TL;DR: It is shown that lentivirus-delivered shRNAs are capable of specific, highly stable and functional silencing of gene expression in a variety of cell types and also in transgenic mice.
Abstract: RNA interference (RNAi) has recently emerged as a specific and efficient method to silence gene expression in mammalian cells either by transfection of short interfering RNAs (siRNAs; ref. 1) or, more recently, by transcription of short hairpin RNAs (shRNAs) from expression vectors and retroviruses. But the resistance of important cell types to transduction by these approaches, both in vitro and in vivo, has limited the use of RNAi. Here we describe a lentiviral system for delivery of shRNAs into cycling and non-cycling mammalian cells, stem cells, zygotes and their differentiated progeny. We show that lentivirus-delivered shRNAs are capable of specific, highly stable and functional silencing of gene expression in a variety of cell types and also in transgenic mice. Our lentiviral vectors should permit rapid and efficient analysis of gene function in primary human and animal cells and tissues and generation of animals that show reduced expression of specific genes. They may also provide new approaches for gene therapy.

Journal ArticleDOI
TL;DR: In this paper, a set of high-redshift supernovae were used to confirm previous supernova evidence for an accelerating universe, and the supernova results were combined with independent flat-universe measurements of the mass density from CMB and galaxy redshift distortion data, they provided a measurement of $w=-1.05^{+0.15}-0.09$ if w is assumed to be constant in time.
Abstract: We report measurements of $\Omega_M$, $\Omega_\Lambda$, and w from eleven supernovae at z=0.36-0.86 with high-quality lightcurves measured using WFPC-2 on the HST. This is an independent set of high-redshift supernovae that confirms previous supernova evidence for an accelerating Universe. Combined with earlier Supernova Cosmology Project data, the new supernovae yield a flat-universe measurement of the mass density $\Omega_M=0.25^{+0.07}_{-0.06}$ (statistical) $\pm0.04$ (identified systematics), or equivalently, a cosmological constant of $\Omega_\Lambda=0.75^{+0.06}_{-0.07}$ (statistical) $\pm0.04$ (identified systematics). When the supernova results are combined with independent flat-universe measurements of $\Omega_M$ from CMB and galaxy redshift distortion data, they provide a measurement of $w=-1.05^{+0.15}_{-0.20}$ (statistical) $\pm0.09$ (identified systematic), if w is assumed to be constant in time. The new data offer greatly improved color measurements of the high-redshift supernovae, and hence improved host-galaxy extinction estimates. These extinction measurements show no anomalous negative E(B-V) at high redshift. The precision of the measurements is such that it is possible to perform a host-galaxy extinction correction directly for individual supernovae without any assumptions or priors on the parent E(B-V) distribution. Our cosmological fits using full extinction corrections confirm that dark energy is required with $P(\Omega_\Lambda>0)>0.99$, a result consistent with previous and current supernova analyses which rely upon the identification of a low-extinction subset or prior assumptions concerning the intrinsic extinction distribution.

Journal ArticleDOI
TL;DR: In this article, the authors present the results of a systematic study of the rest-frame UV spectroscopic properties of Lyman break galaxies (LBGs) and isolate some of the major trends in LBG spectra that are least compromised by selection effects.
Abstract: We present the results of a systematic study of the rest-frame UV spectroscopic properties of Lyman break galaxies (LBGs). The database of almost 1000 LBG spectra proves useful for constructing high signal-to-noise composite spectra. The composite spectrum of the entire sample reveals a wealth of features attributable to hot stars, H II regions, dust, and outflowing neutral and ionized gas. By grouping the database according to galaxy parameters such as Lyα equivalent width, UV spectral slope, and interstellar kinematics, we isolate some of the major trends in LBG spectra that are least compromised by selection effects. We find that LBGs with stronger Lyα emission have bluer UV continua, weaker low-ionization interstellar absorption lines, smaller kinematic offsets between Lyα and the interstellar absorption lines, and lower star formation rates. There is a decoupling between the dependence of low- and high-ionization outflow features on other spectral properties. Additionally, galaxies with rest-frame WLyα ≥ 20 A in emission have weaker than average high-ionization lines and nebular emission lines that are significantly stronger than in the sample as a whole. Most of the above trends can be explained in terms of the properties of the large-scale outflows seen in LBGs. According to this scenario, the appearance of LBG spectra is determined by a combination of the covering fraction of outflowing neutral gas, which contains dust and the range of velocities over which this gas is absorbing. In contrast, the strengths of collisionally excited nebular emission lines should not be affected by the nature of the outflow, and variations in these lines may indicate differences in the temperatures and metallicities in H II regions of galaxies with very strong Lyα emission. Higher sensitivity and spectral resolution observations are still required for a full understanding of the covering fraction and velocity dispersion of the outflowing neutral gas in LBGs and its relationship to the escape fraction of Lyman continuum radiation in galaxies at z ~ 3.

Journal ArticleDOI
23 Oct 2003-Nature
TL;DR: The demonstration of a superconducting detector that is easily fabricated and can readily be incorporated into large arrays, and its sensitivity is already within an order of magnitude of that needed for CMB observations, and the energy resolution is similarly close to the targets required for future X-ray astronomy missions.
Abstract: Cryogenic detectors are extremely sensitive and have a wide variety of applications (particularly in astronomy), but are difficult to integrate into large arrays like a modern CCD (charge-coupled device) camera. As current detectors of the cosmic microwave background (CMB) already have sensitivities comparable to the noise arising from the random arrival of CMB photons, the further gains in sensitivity needed to probe the very early Universe will have to arise from large arrays. A similar situation is encountered at other wavelengths. Single-pixel X-ray detectors now have a resolving power of ΔE < 5 eV for single 6-keV photons, and future X-ray astronomy missions anticipate the need for 1,000-pixel arrays. Here we report the demonstration of a superconducting detector that is easily fabricated and can readily be incorporated into such an array. Its sensitivity is already within an order of magnitude of that needed for CMB observations, and its energy resolution is similarly close to the targets required for future X-ray astronomy missions.

Journal ArticleDOI
TL;DR: This work identifies three fundamental principles that would underlie a delay-tolerant networking (DTN) architecture and describes the main structural elements of that architecture, centered on a new end-to-end overlay network protocol called Bundling.
Abstract: Increasingly, network applications must communicate with counterparts across disparate networking environments characterized by significantly different sets of physical and operational constraints; wide variations in transmission latency are particularly troublesome. The proposed Interplanetary Internet, which must encompass both terrestrial and interplanetary links, is an extreme case. An architecture based on a "least common denominator" protocol that can operate successfully and (where required) reliably in multiple disparate environments would simplify the development and deployment of such applications. The Internet protocols are ill suited for this purpose. We identify three fundamental principles that would underlie a delay-tolerant networking (DTN) architecture and describe the main structural elements of that architecture, centered on a new end-to-end overlay network protocol called Bundling. We also examine Internet infrastructure adaptations that might yield comparable performance but conclude that the simplicity of the DTN architecture promises easier deployment and extension.

Journal ArticleDOI
TL;DR: Based on the excellent radiometric and spectral performance demonstrated by AIRS during prelaunch testing, it is expected the assimilation of AIRS data into the numerical weather forecast to result in significant forecast range and reliability improvements.
Abstract: The Atmospheric Infrared Sounder (AIRS), the Advanced Microwave Sounding Unit (AMSU), and the Humidity Sounder for Brazil (HSB) form an integrated cross-track scanning temperature and humidity sounding system on the Aqua satellite of the Earth Observing System (EOS). AIRS is an infrared spectrometer/radiometer that covers the 3.7-15.4-/spl mu/m spectral range with 2378 spectral channels. AMSU is a 15-channel microwave radiometer operating between 23 and 89 GHz. HSB is a four-channel microwave radiometer that makes measurements between 150 and 190 GHz. In addition to supporting the National Aeronautics and Space Administration's interest in process study and climate research, AIRS is the first hyperspectral infrared radiometer designed to support the operational requirements for medium-range weather forecasting of the National Ocean and Atmospheric Administration's National Centers for Environmental Prediction (NCEP) and other numerical weather forecasting centers. AIRS, together with the AMSU and HSB microwave radiometers, will achieve global retrieval accuracy of better than 1 K in the lower troposphere under clear and partly cloudy conditions. This paper presents an overview of the science objectives, AIRS/AMSU/HSB data products, retrieval algorithms, and the ground-data processing concepts. The EOS Aqua was launched on May 4, 2002 from Vandenberg AFB, CA, into a 705-km-high, sun-synchronous orbit. Based on the excellent radiometric and spectral performance demonstrated by AIRS during prelaunch testing, which has by now been verified during on-orbit testing, we expect the assimilation of AIRS data into the numerical weather forecast to result in significant forecast range and reliability improvements.

Journal ArticleDOI
TL;DR: The AMSR-E sensor calibration and extent of radio frequency interference are currently being assessed, to be followed by quantitative assessments of the soil moisture retrievals, which will provide evaluations of the retrieved soil moisture and enable improved hydrologic applications of the data.
Abstract: The Advanced Microwave Scanning Radiometer (AMSR-E) on the Earth Observing System (EOS) Aqua satellite was launched on May 4, 2002. The AMSR-E instrument provides a potentially improved soil moisture sensing capability over previous spaceborne radiometers such as the Scanning Multichannel Microwave Radiometer and Special Sensor Microwave/Imager due to its combination of low frequency and higher spatial resolution (approximately 60 km at 6.9 GHz). The AMSR-E soil moisture retrieval approach and its implementation are described in this paper. A postlaunch validation program is in progress that will provide evaluations of the retrieved soil moisture and enable improved hydrologic applications of the data. Key aspects of the validation program include assessments of the effects on retrieved soil moisture of variability in vegetation water content, surface temperature, and spatial heterogeneity. Examples of AMSR-E brightness temperature observations over land are shown from the first few months of instrument operation, indicating general features of global vegetation and soil moisture variability. The AMSR-E sensor calibration and extent of radio frequency interference are currently being assessed, to be followed by quantitative assessments of the soil moisture retrievals.

Journal ArticleDOI
TL;DR: Application of this model has allowed for the prediction and development of selective cross metathesis reactions, culminating in unprecedented three-component intermolecular cross metAthesis reactions.
Abstract: In recent years, olefin cross metathesis (CM) has emerged as a powerful and convenient synthetic technique in organic chemistry; however, as a general synthetic method, CM has been limited by the lack of predictability in product selectivity and stereoselectivity. Investigations into olefin cross metathesis with several classes of olefins, including substituted and functionalized styrenes, secondary allylic alcohols, tertiary allylic alcohols, and olefins with α-quaternary centers, have led to a general model useful for the prediction of product selectivity and stereoselectivity in cross metathesis. As a general ranking of olefin reactivity in CM, olefins can be categorized by their relative abilities to undergo homodimerization via cross metathesis and the susceptibility of their homodimers toward secondary metathesis reactions. When an olefin of high reactivity is reacted with an olefin of lower reactivity (sterically bulky, electron-deficient, etc.), selective cross metathesis can be achieved using fee...

Journal ArticleDOI
04 Dec 2003-Nature
TL;DR: A mass-spectrometry-based proteomic analysis of human centrosomes in the interphase of the cell cycle by quantitatively profiling hundreds of proteins across several centrifugation fractions identified and validated 23 novel components and identified 41 likely candidates as well as the vast majority of the known centrosomal proteins in a large background of nonspecific proteins.
Abstract: The centrosome is the major microtubule-organizing centre of animal cells and through its influence on the cytoskeleton is involved in cell shape, polarity and motility. It also has a crucial function in cell division because it determines the poles of the mitotic spindle that segregates duplicated chromosomes between dividing cells. Despite the importance of this organelle to cell biology and more than 100 years of study, many aspects of its function remain enigmatic and its structure and composition are still largely unknown. We performed a mass-spectrometry-based proteomic analysis of human centrosomes in the interphase of the cell cycle by quantitatively profiling hundreds of proteins across several centrifugation fractions. True centrosomal proteins were revealed by both correlation with already known centrosomal proteins and in vivo localization. We identified and validated 23 novel components and identified 41 likely candidates as well as the vast majority of the known centrosomal proteins in a large background of nonspecific proteins. Protein correlation profiling permits the analysis of any multiprotein complex that can be enriched by fractionation but not purified to homogeneity.

Journal ArticleDOI
TL;DR: The SIRTF Nearby Galaxy Survey (SINGS) as mentioned in this paper is a comprehensive infrared imaging and spectroscopic survey of 75 nearby galaxies and its primary goal is to characterize the infrared emission of galaxies and their principal infrared-emitting components across a broad range of galaxy properties and star formation environments.
Abstract: The SIRTF Nearby Galaxy Survey is a comprehensive infrared imaging and spectroscopic survey of 75 nearby galaxies. Its primary goal is to characterize the infrared emission of galaxies and their principal infrared-emitting components, across a broad range of galaxy properties and star formation environments. SINGS will provide new insights into the physical processes connecting star formation to the interstellar medium properties of galaxies and provide a vital foundation for understanding infrared observations of the distant universe and ultraluminous and active galaxies. The galaxy sample and observing strategy have been designed to maximize the scientific and archival value of the data set for the SIRTF user community at large. The SIRTF images and spectra will be supplemented by a comprehensive multiwavelength library of ancillary and complementary observations, including radio continuum, H i, CO, submillimeter, BVRIJHK ,H a ,P aa, ultraviolet, and X-ray data. This paper describes the main astrophysical issues to be addressed by SINGS, the galaxy sample and the observing strategy, and the SIRTF and other ancillary data products.

Journal ArticleDOI
TL;DR: This framework offers a coherent scheme for explaining the neural correlates of (visual) consciousness in terms of competing cellular assemblies and outlines some general experimental approaches to the problem.
Abstract: Here we summarize our present approach to the problem of consciousness. After an introduction outlining our general strategy, we describe what is meant by the term 'framework' and set it out under ten headings. This framework offers a coherent scheme for explaining the neural correlates of (visual) consciousness in terms of competing cellular assemblies. Most of the ideas we favor have been suggested before, but their combination is original. We also outline some general experimental approaches to the problem and, finally, acknowledge some relevant aspects of the brain that have been left out of the proposed framework.

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TL;DR: The HITRAN compilation consists of several components useful for radiative transfer calculation codes: high-resolution spectroscopic parameters of molecules in the gas phase, absorption cross-sections for molecules with very dense spectral features, aerosol refractive indices, ultraviolet line-by-line parameters and absorptionCross-sections, and associated database management software.
Abstract: This paper describes the status circa 2001, of the HITRAN compilation that comprises the public edition available through 2001. The HITRAN compilation consists of several components useful for radiative transfer calculation codes: high-resolution spectroscopic parameters of molecules in the gas phase, absorption cross-sections for molecules with very dense spectral features, aerosol refractive indices, ultraviolet line-by-line parameters and absorption cross-sections, and associated database management software. The line-by-line portion of the database contains spectroscopic parameters for 38 molecules and their isotopologues and isotopomers suitable for calculating atmospheric transmission and radiance properties. Many more molecular species are presented in the infrared cross-section data than in the previous edition, especially the chlorofluorocarbons and their replacement gases. There is now sufficient representation so that quasi-quantitative simulations can be obtained with the standard radiance codes. In addition to the description and justification of new or modified data that have been incorporated since the last edition of HITRAN (1996), future modifications are indicated for cases considered to have a significant impact on remote-sensing experiments. (C) 2003 Elsevier Ltd. All rights reserved.

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TL;DR: It is found that in a reasonable time, a qubit can be directly transmitted with better than classical fidelity across the full length of chains of up to 80 spins, and the channel allows distillable entanglement to be shared over arbitrary distances.
Abstract: We propose a scheme for using an unmodulated and unmeasured spin chain as a channel for short distance quantum communications. The state to be transmitted is placed on one spin of the chain and received later on a distant spin with some fidelity. We first obtain simple expressions for the fidelity of quantum state transfer and the amount of entanglement sharable between any two sites of an arbitrary Heisenberg ferromagnet using our scheme. We then apply this to the realizable case of an open ended chain with nearest neighbor interactions. The fidelity of quantum state transfer is obtained as an inverse discrete cosine transform and as a Bessel function series. We find that in a reasonable time, a qubit can be directly transmitted with better than classical fidelity across the full length of chains of up to 80 spins. Moreover, our channel allows distillable entanglement to be shared over arbitrary distances.