École Polytechnique Fédérale de Lausanne

About: École Polytechnique Fédérale de Lausanne is a facility organization based out in Lausanne, Switzerland. It is known for research contribution in the topics: Population & Catalysis. The organization has 44041 authors who have published 98296 publications receiving 4372092 citations. The organization is also known as: EPFL & ETHL.

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

Abstract: New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new class of antimycobacterial agents that kill Mycobacterium tuberculosis in vitro, ex vivo, and in mouse models of TB. Using genetics and biochemistry, we identified the enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase as a major BTZ target. Inhibition of this enzymatic activity abolishes the formation of decaprenylphosphoryl arabinose, a key precursor that is required for the synthesis of the cell-wall arabinans, thus provoking cell lysis and bacterial death. The most advanced compound, BTZ043, is a candidate for inclusion in combination therapies for both drug-sensitive and extensively drug-resistant TB.

Growth of Saccharomyces cerevisiae is controlled by its limited respiratory capacity: Formulation and verification of a hypothesis

Abstract: A novel mechanistic model for the growth of baker's yeast on glucoseis presented. It is based on the fact that glucose degradation proceeds via two pathways under conditions of aerobic ethanol formation. Part is metabolized oxidatively and part reductively, with ethanol being the end product of reductive energy metabolism. The corresponding metabolic state is designated oxidoreductive. Ethanol can be used oxidatively only. Maximum rates of oxidative glucose and ethanol degradation are governed by the respiratory capacity of the cells. The model is formulated by using the stoichiometric growth equations for pure oxidative and reductive (fermentative) glucose and ethanol metabolism. Together with the experimentally determinable yield coefficients (Y(X/S)) for the respective metabolic pathways, the resulting equation system is sufficiently determined. The superiority of the presented model over hitherto published ones is based on two essential novelities. (1) The model was developed on experimentally easily accessible parameters only. (2) For the modeling of aerobic ethanol formation, the substrate flow was split into two simultaneously operating (i.e., in parallel) metabolic pathways that exhibit different but constant energy-generating efficiencies (respiration and fermentation) and consequently different and constant biomass yields (Y(X/S)). The model allows the prediction of experimental data without parameter adaption in a biologically dubious manner.

Calcium pump of the plasma membrane

Abstract: Article de synthese sur les pompes calciques de la membrane plasmique proprietes generales de ces pompes, stimulation par la calmoduline ou par d'autres traitements, inhibiteur. Synthese sur la structure primaire de ces ATPases, sur leur regulation hormonale et sur les alterations pathologiques affectant leur integrite chez les mammiferes. Methodes de purification et proteolyse

Merging meets matching in MC@NLO

Abstract: The next-to-leading order accuracy for MC@NLO results exclusive in J light jets is achieved if the computation is based on matrix elements that feature J and J+1 QCD partons. The simultaneous prediction of observables which are exclusive in different light-jet multiplicities cannot simply be obtained by summing the above results over the relevant range in J; rather, a suitable merging procedure must be defined. We address the problem of such a merging, and propose a solution that can be easily incorporated into existing MC@NLO implementations. We use the automated aMC@NLO framework to illustrate how the method works in practice, by considering the production at the 8TeV LHC of a Standard Model Higgs in association with up to J = 2 jets, and of an e(+)nu(e) pair or a t (t) over bar pair in association with up to J = 1 jet.

Unreacted PbI2 as a Double-Edged Sword for Enhancing the Performance of Perovskite Solar Cells

Abstract: Lead halide perovskites have over the past few years attracted considerable interest as photo absorbers in PV applications with record efficiencies now reaching 22%. It has recently been found that not only the composition but also the precise stoichiometry is important for the device performance. Recent reports have, for example, demonstrated small amount of PbI2 in the perovskite films to be beneficial for the overall performance of both the standard perovskite, CH3NH3PbI3, as well as for the mixed perovskites (CH3NH3)x(CH(NH2)2)(1–x)PbBryI(3–y). In this work a broad range of characterization techniques including X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), photo electron spectroscopy (PES), transient absorption spectroscopy (TAS), UV–vis, electroluminescence (EL), photoluminescence (PL), and confocal PL mapping have been used to further understand the importance of remnant PbI2 in perovskite solar cells. Our best devices were over 18% efficient, a...