Indian Institute of Technology Bombay

About: Indian Institute of Technology Bombay is a education organization based out in Mumbai, India. It is known for research contribution in the topics: Catalysis & Computer science. The organization has 16756 authors who have published 33588 publications receiving 570559 citations.

Annotating and searching web tables using entities, types and relationships

Abstract: Tables are a universal idiom to present relational data. Billions of tables on Web pages express entity references, attributes and relationships. This representation of relational world knowledge is usually considerably better than completely unstructured, free-format text. At the same time, unlike manually-created knowledge bases, relational information mined from "organic" Web tables need not be constrained by availability of precious editorial time. Unfortunately, in the absence of any formal, uniform schema imposed on Web tables, Web search cannot take advantage of these high-quality sources of relational information. In this paper we propose new machine learning techniques to annotate table cells with entities that they likely mention, table columns with types from which entities are drawn for cells in the column, and relations that pairs of table columns seek to express. We propose a new graphical model for making all these labeling decisions for each table simultaneously, rather than make separate local decisions for entities, types and relations. Experiments using the YAGO catalog, DB-Pedia, tables from Wikipedia, and over 25 million HTML tables from a 500 million page Web crawl uniformly show the superiority of our approach. We also evaluate the impact of better annotations on a prototype relational Web search tool. We demonstrate clear benefits of our annotations beyond indexing tables in a purely textual manner.

Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity.

Abstract: The assembly and stability of FtsZ protofilaments have been shown to play critical roles in bacterial cytokinesis. Recent evidence suggests that FtsZ may be considered as an important antibacterial drug target. Curcumin, a dietary polyphenolic compound, has been shown to have a potent antibacterial activity against a number of pathogenic bacteria including Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus. We found that curcumin induced filamentation in the Bacillus subtilis 168, suggesting that it inhibits bacterial cytokinesis. Further, curcumin strongly inhibited the formation of the cytokinetic Z-ring in B. subtilis 168 without detectably affecting the segregation and organization of the nucleoids. Since the assembly dynamics of FtsZ protofilaments plays a major role in the formation and functioning of the Z-ring, we analysed the effects of curcumin on the assembly of FtsZ protofilaments. Curcumin inhibited the assembly of FtsZ protofilaments and also increased the GTPase activity of FtsZ. Electron microscopic analysis showed that curcumin reduced the bundling of FtsZ protofilaments in vitro. Further, curcumin was found to bind to FtsZ in vitro with a dissociation constant of 7.3+/-1.8 microM and the agent also perturbed the secondary structure of FtsZ. The results indicate that the perturbation of the GTPase activity of FtsZ assembly is lethal to bacteria and suggest that curcumin inhibits bacterial cell proliferation by inhibiting the assembly dynamics of FtsZ in the Z-ring.