Jagiellonian University

About: Jagiellonian University is a education organization based out in Krakow, Poland. It is known for research contribution in the topics: Population & Catalysis. The organization has 17438 authors who have published 44092 publications receiving 862633 citations. The organization is also known as: Academia Cracoviensis & Akademia Krakowska.

A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study of Oral Sildenafil Citrate in Treatment-Naive Children With Pulmonary Arterial Hypertension

Abstract: Background—Safe, effective therapy is needed for pediatric pulmonary arterial hypertension. Methods and Results—Children (n=235; weight ≥8 kg) were randomized to low-, medium-, or high-dose sildenafil or placebo orally 3 times daily for 16 weeks in the Sildenafil in Treatment-Naive Children, Aged 1–17 Years, With Pulmonary Arterial Hypertension (STARTS-1) study. The primary comparison was percent change from baseline in peak oxygen consumption (PVo2) for the 3 sildenafil doses combined versus placebo. Exercise testing was performed in 115 children able to exercise reliably; the study was powered for this population. Secondary end points (assessed in all patients) included hemodynamics and functional class. The estimated mean±SE percent change in PVo2 for the 3 doses combined versus placebo was 7.7±4.0% (95% confidence interval, −0.2% to 15.6%; P=0.056). PVo2, functional class, and hemodynamics improved with medium and high doses versus placebo; low-dose sildenafil was ineffective. Most adverse events w...

On the evolution of the nuclear modification factors with rapidity and centrality in d + Au collisions at s(NN)**(1/2) = 200-GeV

Abstract: We report on a study of the transverse momentum dependence of nuclear modification factors ${R}_{d\mathrm{A}\mathrm{u}}$ for charged hadrons produced in $\mathrm{\text{deuteron}}\text{ }\text{ }+\text{ }\text{ }\mathrm{\text{gold}}$ collisions at $\sqrt{{s}_{NN}}=200\text{ }\text{ }\mathrm{G}\mathrm{e}\mathrm{V}$, as a function of collision centrality and of the pseudorapidity ($\ensuremath{\eta}=0$, 1, 2.2, 3.2) of the produced hadrons. We find a significant and systematic decrease of ${R}_{d\mathrm{A}\mathrm{u}}$ with increasing rapidity. The midrapidity enhancement and the forward rapidity suppression are more pronounced in central collisions relative to peripheral collisions. These results are relevant to the study of the possible onset of gluon saturation at energies reached at BNL RHIC.

Challenges and Controversies in Human Mesenchymal Stem Cell Therapy.

Abstract: Stem cell therapy is being intensely investigated within the last years. Expectations are high regarding mesenchymal stem cell (MSC) treatment in translational medicine. However, many aspects concerning MSC therapy should be profoundly defined. Due to a variety of approaches that are investigated, potential effects of stem cell therapy are not transparent. On the other hand, most results of MSC administration in vivo have confirmed their safety and showed promising beneficial outcomes. However, the therapeutic effects of MSC-based treatment are still not spectacular and there is a potential risk related to MSC applications into specific cell niche that should be considered in long-term observations and follow-up outcomes. In this review, we intend to address some problems and critically discuss the complex nature of MSCs in the context of their effective and safe applications in regenerative medicine in different diseases including graft versus host disease (GvHD) and cardiac, neurological, and orthopedic disorders.

Neutrinos from the primary proton–proton fusion process in the Sun

Abstract: Spectral observations of the low-energy neutrinos produced by proton–proton fusion in the Sun demonstrate that about 99 per cent of the Sun’s power is generated by this process.