Institution
Jagiellonian University
Education•Krakow, Poland•
About: Jagiellonian University is a education organization based out in Krakow, Poland. It is known for research contribution in the topics: Population & Catalysis. The organization has 17438 authors who have published 44092 publications receiving 862633 citations. The organization is also known as: Academia Cracoviensis & Akademia Krakowska.
Papers published on a yearly basis
Papers
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Royal Netherlands Academy of Arts and Sciences1, University of Sheffield2, Wageningen University and Research Centre3, University of Illinois at Urbana–Champaign4, University of Oxford5, Washington University in St. Louis6, University of Antwerp7, Polytechnic University of Valencia8, Moscow State University9, Jagiellonian University10, Max Planck Society11, University of Turku12, University of Natural Resources and Life Sciences, Vienna13, University of Tartu14, University of Glasgow15, University of Coimbra16, University of Oulu17, University of Bern18, Rikshospitalet–Radiumhospitalet19, University of Groningen20, Eötvös Loránd University21, University of Zurich22, Hokkaido University23
TL;DR: The high-quality great tit genome assembly is assembled, showing an overrepresentation of genes related to neuronal functions, learning and cognition in regions under positive selection, as well as increased CpG methylation in these regions.
Abstract: For over 50 years, the great tit (Parus major) has been a model species for research in evolutionary, ecological and behavioural research; in particular, learning and cognition have been intensively studied. Here, to provide further insight into the molecular mechanisms behind these important traits, we de novo assemble a great tit reference genome and whole-genome re-sequence another 29 individuals from across Europe. We show an overrepresentation of genes related to neuronal functions, learning and cognition in regions under positive selection, as well as increased CpG methylation in these regions. In addition, great tit neuronal non-CpG methylation patterns are very similar to those observed in mammals, suggesting a universal role in neuronal epigenetic regulation which can affect learning-, memory- and experience-induced plasticity. The high-quality great tit genome assembly will play an instrumental role in furthering the integration of ecological, evolutionary, behavioural and genomic approaches in this model species.
175 citations
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TL;DR: The volume of the (N 2 − 1)-dimensional set N of density matrices of size N with respect to the Bures measure was shown to be equal to that of an (N2 − 1)dimensional hyper-hemisphere of radius 1/2 in this article.
Abstract: We compute the volume of the (N2 − 1)-dimensional set N of density matrices of size N with respect to the Bures measure and show that it is equal to that of an (N2 − 1)-dimensional hyper-hemisphere of radius 1/2. For N = 2 we obtain the volume of the Uhlmann hemisphere, ½S3 ⊂ 4. We find also the area of the boundary of the set N and obtain analogous results for the smaller set of all real density matrices. An explicit formula for the Bures–Hall normalization constants is derived for an arbitrary N.
175 citations
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French Institute of Health and Medical Research1, University of Amsterdam2, National Institutes of Health3, Ghent University4, Swiss Institute of Allergy and Asthma Research5, University of Genoa6, Karolinska Institutet7, Charité8, University of Bonn9, Seconda Università degli Studi di Napoli10, University of Manchester11, Erasmus University Rotterdam12, University of Southampton13, University of Paris-Sud14, Medical University of Łódź15, Centre national de la recherche scientifique16, University of Oslo17, German Red Cross18, Jagiellonian University19, National and Kapodistrian University of Athens20, University of Bern21, University of Coimbra22, Finnish Institute of Occupational Health23, Medical University of Vienna24, Boston Children's Hospital25
TL;DR: Characterization of the phenotype, mechanisms and management of NAR represents one of the major unmet needs in allergic and nonallergic diseases and its phenotypes need to be evaluated using appropriate methods to better understand its pathophysiology, diagnosis and management.
Abstract: Nonallergic rhinitis (NAR) can be defined as a chronic nasal inflammation which is not caused by systemic IgE-dependent mechanisms. It is common and probably affects far more than 200 million people worldwide. Both children and adults are affected. However, its exact prevalence is unknown and its phenotypes need to be evaluated using appropriate methods to better understand its pathophysiology, diagnosis and management. It is important to differentiate between infectious rhinitis, allergic/NAR and chronic rhinosinusitis, as management differs for each of these cases. Characterization of the phenotype, mechanisms and management of NAR represents one of the major unmet needs in allergic and nonallergic diseases. Studies on children and adults are required in order to appreciate the prevalence, phenotype, severity and co-morbidities of NAR. These studies should compare allergic and NAR and consider different age group populations including elderly subjects. Mechanistic studies should be carried out to better understand the disease(s) and risk factors and to guide towards an improved diagnosis and therapy. These studies need to take the heterogeneity of NAR into account. It is likely that neuronal mechanisms, T cells, innate immunity and possibly auto-immune responses all play a role in NAR and may also contribute to the symptoms of allergic rhinitis.
175 citations
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TL;DR: Results indicate that heme oxygenase-1 is involved in an important protective mechanism against PDT-mediated phototoxicity and administration of HO-1 inhibitors might be an effective way to potentiate antitumor effectiveness of PDT.
Abstract: Photodynamic therapy is a promising antitumor treatment modality approved for the management of both early and advanced tumors. The mechanisms of its antitumor action include generation of singlet oxygen and reactive oxygen species that directly damage tumor cells and tumor vasculature. A number of mechanisms seem to be involved in the protective responses to PDT that include activation of transcription factors, heat shock proteins, antioxidant enzymes and antiapoptotic pathways. Elucidation of these mechanisms might result in the design of more effective combination strategies to improve the antitumor efficacy of PDT. Using DNA microarray analysis to identify stress-related genes induced by Photofrin-mediated PDT in colon adenocarcinoma C-26 cells, we observed a marked induction of heme oxygenase-1 (HO-1). Induction of HO-1 with hemin or stable transfection of C-26 with a plasmid vector encoding HO-1 increased resistance of tumor cells to PDT-mediated cytotoxicity. On the other hand, zinc (II) protoporphyrin IX, an HO-1 inhibitor, markedly augmented PDT-mediated cytotoxicity towards C-26 and human ovarian carcinoma MDAH2774 cells. Neither bilirubin, biliverdin nor carbon monoxide, direct products of HO-1 catalysed heme degradation, was responsible for cytoprotection. Importantly, desferrioxamine, a potent iron chelator significantly potentiated cytotoxic effects of PDT. Altogether our results indicate that HO-1 is involved in an important protective mechanism against PDT-mediated phototoxicity and administration of HO-1 inhibitors might be an effective way to potentiate antitumor effectiveness of PDT.
175 citations
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Harvard University1, INAF2, University of Hamburg3, University of Hertfordshire4, Leiden University5, Lawrence Livermore National Laboratory6, University of Minnesota7, University of Edinburgh8, University of Virginia9, Jagiellonian University10, University of Southampton11, ASTRON12, Max Planck Society13, Centre national de la recherche scientifique14, Netherlands Institute for Space Research15, Chalmers University of Technology16, University of the Western Cape17, National Radio Astronomy Observatory18, Johns Hopkins University19, University of Groningen20, Japan Aerospace Exploration Agency21, Rutherford Appleton Laboratory22
TL;DR: In this article, the authors presented deep LOFAR observations between 120 and 181 MHz of the "Toothbrush" (RX J0603.3+ 4214), a cluster that contains one of the brightest radio relic sources known.
Abstract: We present deep LOFAR observations between 120 and 181 MHz of the "Toothbrush" (RX J0603.3+ 4214), a cluster that contains one of the brightest radio relic sources known. Our LOFAR observations exploit a new and novel calibration scheme to probe 10 times deeper than any previous study in this relatively unexplored part of the spectrum. The LOFAR observations, when combined with VLA, GMRT, and Chandra X-ray data, provide new information about the nature of cluster merger shocks and their role in re-accelerating relativistic particles. We derive a spectral index of alpha = -0.8 +/- 0.1 at the northern edge of the main radio relic, steepening toward the south to alpha approximate to-2. The spectral index of the radio halo is remarkably uniform (alpha = -1.16, with an intrinsic scatter of <= 0.04). The observed radio relic spectral index gives a Mach number of M = 2.8(-0.3)(+0.5), assuming diffusive shock acceleration. However, the gas density jump at the northern edge of the large radio relic implies a much weaker shock (M approximate to 1.2, with an upper limit of M approximate to 1.5). The discrepancy between the Mach numbers calculated from the radio and X-rays can be explained if either (i) the relic traces a complex shock surface along the line of sight, or (ii) if the radio relic emission is produced by a re-accelerated population of fossil particles from a radio galaxy. Our results highlight the need for additional theoretical work and numerical simulations of particle acceleration and re-acceleration at cluster merger shocks.
174 citations
Authors
Showing all 17729 results
Name | H-index | Papers | Citations |
---|---|---|---|
Roxana Mehran | 141 | 1378 | 99398 |
Brad Abbott | 137 | 1566 | 98604 |
M. Morii | 134 | 1664 | 102074 |
M. Franklin | 134 | 1581 | 95304 |
John Huth | 131 | 1087 | 85341 |
Wladyslaw Dabrowski | 129 | 990 | 79728 |
Rostislav Konoplich | 128 | 811 | 73790 |
Michel Vetterli | 128 | 901 | 76064 |
Francois Corriveau | 128 | 1022 | 75729 |
Christoph Falk Anders | 126 | 734 | 68828 |
Tomasz Bulik | 121 | 698 | 86211 |
Elzbieta Richter-Was | 118 | 793 | 69127 |
S. H. Robertson | 116 | 1311 | 58582 |
S. J. Chen | 116 | 1559 | 62804 |
David M. Stern | 107 | 271 | 47461 |