Institution
Kumamoto University
Education•Kumamoto, Kumamoto, Japan•
About: Kumamoto University is a education organization based out in Kumamoto, Kumamoto, Japan. It is known for research contribution in the topics: Cancer & Population. The organization has 19602 authors who have published 35513 publications receiving 901260 citations. The organization is also known as: Kumamoto Daigaku.
Topics: Cancer, Population, Gene, Cell culture, Receptor
Papers published on a yearly basis
Papers
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TL;DR: GPC3, as defined in this study was shown to be a useful tumor marker for cancer-diagnosis for large numbers of patients with HCC.
428 citations
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TL;DR: The results demonstrate the rapid induction of ventricular BNP gene expression in rats with AMI compared with ANP and suggest that BNPGene expression in the ventricle is regulated distinctively from ANP gene expression against acute ventricular overload.
Abstract: Background We have demonstrated that brain natriuretic peptide (BNP) is a cardiac hormone predominantly synthesized in and secreted from the ventricle. We have also reported that, compared with atrial natriuretic peptide (ANP), the plasma concentration of BNP is increased to a greater degree in patients with congestive heart failure and more rapidly in patients with acute myocardial infarction (AMI). Methods and Results To investigate ventricular gene expression of BNP in AMI, we analyzed plasma and ventricular BNP concentrations along with ventricular BNP mRNA in rats with AMI produced by coronary artery ligation. The BNP concentration in the left ventricle increased about 2-fold as early as 12 hours postinfarction and 5-fold 1 day postinfarction compared with sham-operated rats, whereas left ventricular ANP concentration remained unchanged within 1 day. The tissue concentration of BNP increased in the noninfarcted region as well as in the infarcted region. The surviving myocytes in and around the necrot...
428 citations
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TL;DR: In this paper, the formation and mechanical properties of Mg 97 Zn 1 RE 2 alloys with long-period stacking ordered (LPSO) structures were investigated by examining RE = Y, La, Ce, Pr, Sm, Nd, Dy, Ho, Er, Gd, Tb and Tm LPSO structures.
Abstract: We investigated the formation and mechanical properties of Mg 97 Zn 1 RE 2 alloys with long-period stacking ordered (LPSO) structures by examining RE = Y, La, Ce, Pr, Sm, Nd, Gd, Dy, Ho, Er, Tb, Tm and Yb The LPSO phase developed for RE = Y, Dy, Ho, Er, Gd, Tb and Tm LPSO Mg-Zn-RE alloys are either type I, in which the LPSO phase forms during solidification: Mg-Zn-Y, Mg-Zn-Dy, Mg-Zn-Ho, Mg-Zn-Er and Mg-Zn-Tm, or type II, in which the LPSO phase is nonexistent in as-cast ingots but precipitates with soaking at 773 K: Mg-Zn-Gd and Mg-Zn-Tb The criteria for REs that form an LPSO phase in Mg-Zn-RE alloys are discussed Mg-Zn-RE alloys with an LPSO phase, which were worked by hot extrusion, include high strength both at ambient and elevated temperatures, and good ductility Their tensile yield strength, ultimate strength and elongation were 342-377 MPa, 372-410MPa and 3-9%, respectively at ambient temperature, and 292-310MPa, 322-345 MPa and 4-13% at 473 K The LPSO Mg-Zn-RE alloys are promising candidates for lightweight structural materials
427 citations
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TL;DR: In this paper, a linear relationship between bandgap and band edge was obtained for almost all the semiconductor oxides and it was pointed out that a bandgap energy higher than about 2.46 eV is necessary for water photolysis without bias voltage.
426 citations
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TL;DR: A new type of blue-light receptor flavoprotein, photoactivated adenylyl cyclase, is found in the photoreceptor organelle of Euglena gracilis, with molecular genetic evidence that it mediates the step-up photophobic response.
Abstract: Blue light regulates processes such as the development of plants and fungi and the behaviour of microbes. Two types of blue-light receptor flavoprotein have been identified: cryptochromes, which have partial similarity to photolyases, and phototropins, which are photoregulated protein kinases. The former have also been found in animals with evidence of essential roles in circadian rhythms. Euglena gracilis, a unicellular flagellate, abruptly changes its swimming direction after a sudden increase or decrease in incident blue light intensity, that is, step-up or step-down photophobic responses, resulting in photoavoidance or photoaccumulation, respectively. Although these photobehaviours of Euglena have been studied for a century, the photoreceptor molecules mediating them have remained unknown. Here we report the discovery and biochemical characterization of a new type of blue-light receptor flavoprotein, photoactivated adenylyl cyclase, in the photoreceptor organelle of Euglena gracilis, with molecular genetic evidence that it mediates the step-up photophobic response.
425 citations
Authors
Showing all 19645 results
Name | H-index | Papers | Citations |
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Fred H. Gage | 216 | 967 | 185732 |
George D. Yancopoulos | 158 | 496 | 93955 |
Kenji Kangawa | 153 | 1117 | 110059 |
Tasuku Honjo | 141 | 712 | 88428 |
Hideo Yagita | 137 | 946 | 70623 |
Masashi Yanagisawa | 130 | 524 | 83631 |
Kazuwa Nakao | 128 | 1041 | 70812 |
Kouji Matsushima | 124 | 590 | 56995 |
Thomas E. Mallouk | 122 | 549 | 52593 |
Toshio Hirano | 120 | 401 | 55721 |
Eisuke Nishida | 112 | 349 | 45918 |
Hiroaki Shimokawa | 111 | 949 | 48822 |
Bernd Bukau | 111 | 271 | 38446 |
Kazuo Tsubota | 105 | 1379 | 48991 |
Toshio Suda | 104 | 580 | 41069 |