Institution
Kumamoto University
Education•Kumamoto, Kumamoto, Japan•
About: Kumamoto University is a education organization based out in Kumamoto, Kumamoto, Japan. It is known for research contribution in the topics: Cancer & Population. The organization has 19602 authors who have published 35513 publications receiving 901260 citations. The organization is also known as: Kumamoto Daigaku.
Topics: Cancer, Population, Gene, Cell culture, Receptor
Papers published on a yearly basis
Papers
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TL;DR: It is shown that op/op fibroblasts are defective in production of functional macrophage colony-stimulating factor (M-CSF), although its messenger RNA (Csfm mRNA) is present at normal levels, and it is concluded that the pathological changes in this mutant result from the absence of M- CSF.
Abstract: Mice homozygous for the recessive mutation osteopetrosis (op) on chromosome 3 have a restricted capacity for bone remodelling, and are severely deficient in mature macrophages and osteoclasts. Both cell populations originate from a common haemopoietic progenitor. As op/op mice are not cured by transplants of normal bone marrow cells, the defects in op/op mice may be associated with an abnormal haematopoietic microenvironment rather than with an intrinsic defect in haematopoietic progenitors. To investigate the molecular and biochemical basis of the defects caused by the op mutation, we established primary fibroblast cell lines from op/op mice and tested the ability of these cell lines to support the proliferation of macrophage progenitors. We show that op/op fibroblasts are defective in production of functional macrophage colony-stimulating factor (M-CSF), although its messenger RNA (Csfm mRNA) is present at normal levels. This defect in M-CSF production and the recent mapping of the Csfm structural gene near op on chromosome 3 suggest that op is a mutation within the Csfm gene itself. We have sequenced Csfm complementary DNA prepared from op/op fibroblasts and found a single base pair insertion in the coding region of the Csfm gene that generates a stop codon 21 base pairs downstream. Thus, the op mutation is within the Csfm coding region and we conclude that the pathological changes in this mutant result from the absence of M-CSF.
1,804 citations
TL;DR: While the number of grave cases with acute M. d.
Abstract: Minamata disease (M. d.) is methylmercury (MeHg) poisoning that occurred in humans who ingested fish and shellfish contaminated by MeHg discharged in waste water from a chemical plant (Chisso Co. L...
1,792 citations
National Taiwan University1, Kumamoto University2, Heidelberg University3, University of Münster4, Boston University5, University of Messina6, University of British Columbia7, University of Barcelona8, Columbia University9, Sungkyunkwan University10, Konkuk University11, Istanbul University12, Shinshu University13, University College London14, Harvard University15, Johns Hopkins University16, Mayo Clinic17, Alnylam Pharmaceuticals18, Umeå University19
TL;DR: Patisiran improved multiple clinical manifestations of hereditary transthyretin amyloidosis with polyneuropathy and showed an effect on gait speed and modified BMI.
Abstract: BACKGROUND: Patisiran, an investigational RNA interference therapeutic agent, specifically inhibits hepatic synthesis of transthyretin.METHODS: In this phase 3 trial, we randomly assigned patients ...
1,671 citations
TL;DR: Crystallographic analysis of 17 different complexes of HSA with a wide variety of drugs and small-molecule toxins reveals the precise architecture of the two primary drug-binding sites on the protein, identifying residues that are key determinants of binding specificity and illuminating the capacity of both pockets for flexible accommodation.
1,609 citations
TL;DR: A novel cardiomyopathy with transient apical ballooning, but without coronary artery stenosis, that mimics acute myocardial infarction was reported, and one died suddenly during follow-up.
1,551 citations
Authors
Showing all 19645 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Fred H. Gage | 216 | 967 | 185732 |
| George D. Yancopoulos | 158 | 496 | 93955 |
| Kenji Kangawa | 153 | 1117 | 110059 |
| Tasuku Honjo | 141 | 712 | 88428 |
| Hideo Yagita | 137 | 946 | 70623 |
| Masashi Yanagisawa | 130 | 524 | 83631 |
| Kazuwa Nakao | 128 | 1041 | 70812 |
| Kouji Matsushima | 124 | 590 | 56995 |
| Thomas E. Mallouk | 122 | 549 | 52593 |
| Toshio Hirano | 120 | 401 | 55721 |
| Eisuke Nishida | 112 | 349 | 45918 |
| Hiroaki Shimokawa | 111 | 949 | 48822 |
| Bernd Bukau | 111 | 271 | 38446 |
| Kazuo Tsubota | 105 | 1379 | 48991 |
| Toshio Suda | 104 | 580 | 41069 |