Institution
National Autonomous University of Mexico
Education•Mexico City, Distrito Federal, Mexico•
About: National Autonomous University of Mexico is a education organization based out in Mexico City, Distrito Federal, Mexico. It is known for research contribution in the topics: Population & Galaxy. The organization has 72868 authors who have published 127797 publications receiving 2285543 citations. The organization is also known as: UNAM & Universidad Nacional Autónoma de México.
Topics: Population, Galaxy, Catalysis, Thin film, Stars
Papers published on a yearly basis
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Harvard University1, Broad Institute2, Universidad Autónoma Metropolitana3, National Autonomous University of Mexico4, Universidad Autónoma de Nuevo León5, Massachusetts Institute of Technology6, University of Southern California7, Mexican Social Security Institute8, University of Hawaii at Manoa9, Max Planck Society10, University of Minnesota11, University of California, San Francisco12, National University of Singapore13, University of Oxford14, University of Michigan15, Yeshiva University16, Texas Biomedical Research Institute17, Wake Forest University18, National Health Service19, Imperial College London20, Hallym University21, Hebrew University of Jerusalem22, Wolfson Medical Center23, University of Texas Health Science Center at Houston24, University of Eastern Finland25, Agency for Science, Technology and Research26, University of Mississippi27, University of Texas Health Science Center at San Antonio28
TL;DR: Analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism and an archaic genome sequence indicated that the risk haplotype introgressed into modern humans via admixture with Neanderthals.
Abstract: Performing genetic studies in multiple human populations can identify disease risk alleles that are common in one population but rare in others, with the potential to illuminate pathophysiology, health disparities, and the population genetic origins of disease alleles. Here we analysed 9.2 million single nucleotide polymorphisms (SNPs) in each of 8,214 Mexicans and other Latin Americans: 3,848 with type 2 diabetes and 4,366 non-diabetic controls. In addition to replicating previous findings, we identified a novel locus associated with type 2 diabetes at genome-wide significance spanning the solute carriers SLC16A11 and SLC16A13 (P = 3.9 × 10(-13); odds ratio (OR) = 1.29). The association was stronger in younger, leaner people with type 2 diabetes, and replicated in independent samples (P = 1.1 × 10(-4); OR = 1.20). The risk haplotype carries four amino acid substitutions, all in SLC16A11; it is present at ~50% frequency in Native American samples and ~10% in east Asian, but is rare in European and African samples. Analysis of an archaic genome sequence indicated that the risk haplotype introgressed into modern humans via admixture with Neanderthals. The SLC16A11 messenger RNA is expressed in liver, and V5-tagged SLC16A11 protein localizes to the endoplasmic reticulum. Expression of SLC16A11 in heterologous cells alters lipid metabolism, most notably causing an increase in intracellular triacylglycerol levels. Despite type 2 diabetes having been well studied by genome-wide association studies in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism.
431 citations
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TL;DR: The adsorption energy of the four intermediates, H*, COOH*, CO*, and CH3 O*, can be used to differentiate, group, and explain products in electrochemical reduction processes involving CO2 , CO, and carbon-oxygen compounds.
Abstract: In this work we propose four non-coupled binding energies of intermediates as descriptors, or 'genes', for predicting the product distribution in CO2 electroreduction. Simple reactions can be understood by the Sabatier principle (catalytic activity vs. one descriptor), while more complex reactions tend to give multiple very different products and consequently the product selectivity is a more complex property to understand. We approach this, as a logistical classification problem, by grouping metals according to their major experimental product from CO2 electroreduction: H2, CO, formic acid and beyond CO* (hydrocarbons or alcohols). We compare the groups in terms of multiple binding energies of intermediates calculated by density functional theory. Here we find three descriptors to explain the grouping: the adsorption energies of H*, COOH* and CO*. To further classify products beyond CO*, we carry out formaldehyde experiments on Cu, Ag and Au and combine these results with the literature to group and differentiate alcohol or hydrocarbon products. We find that the oxygen binding (adsorption energy of CH3O*) is an additional descriptor to explain the alcohol formation in reduction processes. Finally, the adsorption energy of the four intermediates, H*, COOH*, CO* and CH3O*, can be used to differentiate, group and explain products in electrochemical reduction processes involving CO2, CO and carbon-oxygen compounds.
430 citations
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TL;DR: The goal of this review is to expose that lactate is not only a secondary product of cellular metabolic waste of tumor cells, but also a key molecule involved in carcinogenesis as well as in tumor immune evasion.
Abstract: Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts of glucose producing large volumes of lactate even in the presence of oxygen, this process is known as "Warburg effect or aerobic glycolysis." As a consequence of such amounts of lactate there is an acidification of the extracellular pH in tumor microenvironment, ranging between 6.0 and 6.5. This acidosis favors processes such as metastasis, angiogenesis and more importantly, immunosuppression, which has been associated to a worse clinical prognosis. Thus, lactate should be thought as an important oncometabolite in the metabolic reprogramming of cancer. In this review, we summarized the role of lactate in regulating metabolic microenvironment of cancer and discuss its relevance in the up-regulation of the enzymes lactate dehydrogenase (LDH) and monocarboxilate transporters (MCTs) in tumors. The goal of this review is to expose that lactate is not only a secondary product of cellular metabolic waste of tumor cells, but also a key molecule involved in carcinogenesis as well as in tumor immune evasion. Finally, the possible targeting of lactate production in cancer treatment is discussed.
430 citations
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TL;DR: This review reports the recent developments in the Hg(II) removal in waste water treatment, using chitosan and its derivatives in order to provide useful information about the different technologies.
430 citations
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TL;DR: The number of species places Mexico as the country with the fourth largest floristic richness in the world, although among the non-insular countries, by its number of endemic species (about 50%) is second only surpassed by South Africa.
Abstract: An updated inventory of the native vascular plants of Mexico records 23,314 species, distributed in 2,854 genera, 297 families, and 73 orders. The flora includes 1,039 species of ferns and lycophytes, 149 gymnosperms, and 22,126 angiosperms. On average, the number of synonyms per species is 1.3 (mode = 1). The number of species places Mexico as the country with the fourth largest floristic richness in the world, although among the non-insular countries, by its number of endemic species (about 50%) is second only surpassed by South Africa. The species distribution among higher taxonomic categories, and the richness and endemism values in the 32 states of Mexico are discussed. This compilation allows us to assess the flora's contribution to the overall Mexican biodiversity.
430 citations
Authors
Showing all 73617 results
Name | H-index | Papers | Citations |
---|---|---|---|
Richard Peto | 183 | 683 | 231434 |
Anton M. Koekemoer | 168 | 1127 | 106796 |
Rory Collins | 162 | 489 | 193407 |
Timothy C. Beers | 156 | 934 | 102581 |
Vivek Sharma | 150 | 3030 | 136228 |
Kjell Fuxe | 142 | 1479 | 89846 |
Prashant V. Kamat | 140 | 725 | 79259 |
Carmen García | 139 | 1503 | 96925 |
Harold A. Mooney | 135 | 450 | 100404 |
Efe Yazgan | 128 | 986 | 79041 |
Roberto Maiolino | 127 | 816 | 61724 |
Peter Nugent | 127 | 754 | 92988 |
William R. Miller | 125 | 601 | 72570 |
Nicholas A. Kotov | 123 | 574 | 55210 |
John C. Wingfield | 122 | 509 | 52291 |