University of Missouri

About: University of Missouri is a education organization based out in Columbia, Missouri, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 41427 authors who have published 83598 publications receiving 2911437 citations. The organization is also known as: Mizzou & Missouri-Columbia.

Measures of depression and depressive symptoms: Beck Depression Inventory-II (BDI-II), Center for Epidemiologic Studies Depression Scale (CES-D), Geriatric Depression Scale (GDS), Hospital Anxiety and Depression Scale (HADS), and Patient Health Questionnaire-9 (PHQ-9).

Abstract: This article presents a summary of self-report adult measures that are considered to be most relevant for the assessment of depression in the context of rheumatology clinical and/or research practice. This piece represents an update of the special issue article that appeared in Arthritis Care & Research in 2003; the current review followed similar selection criteria for inclusion of assessment tools. Specifically, measures were selected based on several considerations, including ease of administration, interpretation, and adoption by arthritis health professionals from varying backgrounds and training perspectives; self-report measures providing data from the patient or research participant’s perspective; availability of adequate psychometric literature and data involving rheumatology populations; and frequent use in both clinical and research practice with adult rheumatology populations. This study was not intended to be exhaustive. Clinicianadministered, semistructured depression interviews requiring specialized training such as the Hamilton Rating Scale for Depression and Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition were not included. Additionally, measures without sufficient use within rheumatology populations, such as the World Health Organization Composite International Diagnostic Interview depression module and the National Institutes of Health Patient-Reported Outcomes Measurement Information System, were also not included in this review. Self-report measures that have been included in this review are as follows: Beck Depression Inventory-II, Center for Epidemiologic Studies Depression Scale, Geriatric Depression Scale, Hospital Anxiety and Depression Scale, and Patient Health Questionnaire-9. Some of these measures have become integrated into routine clinical practice (as screening tools) in large managed-care organizations, and these specifics have been included in this article. Included within each measure review are “additional references” that, while not cited within the review itself, may be of interest to the arthritis health professional who intends to use this instrument in their clinical practice or as part of a research study. As a general comment regarding any assessment of depression, while care was taken to include measures that require little training to administer and interpret, users without psychological background/experience in the management of clinical issues related to depression and crisis situations may need contingency plans for clinical supervision and/or referral sources. Any individual meeting or close to meeting the diagnostic criteria for depressive disorders needs appropriate management and/or referral, including being provided with referral options for different treatment approaches (pharmacologic and/or psychological). Additionally, suicide risk associated with depression must be taken seriously and promptly addressed. Clinicians should have existing plans to immediately deal with anyone who is an imminent danger to self or others (including mandated reporting). Researchers and clinicians ought to identify behavioral health experts (e.g., psychologists, psychiatrists, social workers) who can assist with appropriately handling these types of crisis situations should they be identified in the context of rheumatology clinical or research environments.

Effects of alcohol on human aggression: an integrative research review

Abstract: This review used quantitative and qualitative techniques to integrate the alcohol and aggression literature. The primary purpose of the review was to determine if a causal relation exists between alcohol and aggression. The main meta-analysis included 30 experimental studies that used between-subjects designs, male confederates, and male subjects who were social drinkers. Studies using other designs or subject populations were integrated with meta-analytic procedures when possible and summarized descriptively when not. The results of the review indicate that alcohol does indeed cause aggression. However, alcohol effects were moderated by certain methodological parameters.

Sense of Belonging in College Freshmen at the Classroom and Campus Levels.

Abstract: The importance of students' sense of school belonging for many adaptive outcomes is becoming well established; however, few researchers have focused on college-aged populations. In this study, the authors examined associations between undergraduate students' sense of class belonging and their academic motivation in that class, their sense of class belonging and perceptions of their instructors' characteristics, and their class and campus-level sense of belonging. They distributed questionnaires to students at a southeastern university; freshmen (N = 238) completed the questionnaire. The authors found associations between (a) students' sense of class belonging and their academic self-efficacy, intrinsic motivation, and task value; (b) students' sense of class-level belonging and their perceptions of instructors' warmth and openness, encouragement of student participation, and organization; and (c) students' sense of university-level belonging and their sense of social acceptance. The authors found smaller ...

Stomatal Development and Patterning Are Regulated by Environmentally Responsive Mitogen-Activated Protein Kinases in Arabidopsis

Abstract: Stomata are specialized epidermal structures that regulate gas (CO2 and O2) and water vapor exchange between plants and their environment. In Arabidopsis thaliana, stomatal development is preceded by asymmetric cell divisions, and stomatal distribution follows the one-cell spacing rule, reflecting the coordination of cell fate specification. Stomatal development and patterning are regulated by both genetic and environmental signals. Here, we report that Arabidopsis MITOGEN-ACTIVATED PROTEIN KINASE3 (MPK3) and MPK6, two environmentally responsive mitogen-activated protein kinases (MAPKs), and their upstream MAPK kinases, MKK4 and MKK5, are key regulators of stomatal development and patterning. Loss of function of MKK4/MKK5 or MPK3/MPK6 disrupts the coordinated cell fate specification of stomata versus pavement cells, resulting in the formation of clustered stomata. Conversely, activation of MKK4/MKK5-MPK3/MPK6 causes the suppression of asymmetric cell divisions and stomatal cell fate specification, resulting in a lack of stomatal differentiation. We further establish that the MKK4/MKK5-MPK3/MPK6 module is downstream of YODA, a MAPKKK. The establishment of a complete MAPK signaling cascade as a key regulator of stomatal development and patterning advances our understanding of the regulatory mechanisms of intercellular signaling events that coordinate cell fate specification during stomatal development.

Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial. Inhaled Nitric Oxide in ARDS Study Group.

Abstract: Objectives To evaluate the safety and physiologic response of inhaled nitric oxide (NO) in patients with acute respiratory distress syndrome (ARDS). In addition, the effect of various doses of inhaled NO on clinical outcome parameters was assessed. Design Prospective, multicenter, randomized, double-blind, placebo-controlled study. Setting Intensive care units of 30 academic, teaching, and community hospitals in the United States. Patients Patients with ARDS, as defined by the American-European Consensus Conference, were enrolled into the study if the onset of disease was within 72 hrs of randomization. Interventions Patients were randomized to receive placebo (nitrogen gas) or inhaled NO at concentrations of 1.25, 5, 20, 40, or 80 ppm. Measurements and main results Acute increases in PaO2, decreases in mean pulmonary arterial pressure, intensity of mechanical ventilation, and oxygenation index were examined. Clinical outcomes examined were the dose effects of inhaled NO on mortality, the number of days alive and off mechanical ventilation, and the number of days alive after meeting oxygenation criteria for extubation. A total of 177 patients were enrolled over a 14-month period. An acute response to treatment gas, defined as a PaO2 increase > or =20%, was seen in 60% of the patients receiving inhaled NO with no significant differences between dose groups. Twenty-four percent of placebo patients also had an acute response to treatment gas during the first 4 hrs. The initial increase in oxygenation translated into a reduction in the FIO2 over the first day and in the intensity of mechanical ventilation over the first 4 days of treatment, as measured by the oxygenation index. There were no differences among the pooled inhaled NO groups and placebo with respect to mortality rate, the number of days alive and off mechanical ventilation, or the number of days alive after meeting oxygenation criteria for extubation. However, patients receiving 5 ppm inhaled NO showed an improvement in these parameters. In this dose group, the percentage of patients alive and off mechanical ventilation at day 28 (a post hoc analysis) was higher (62% vs. 44%) than the placebo group. There was no apparent difference in the number or type of adverse events reported among those patients receiving inhaled NO compared with placebo. Four patients had methemoglobin concentrations >5%. The mean inspired nitrogen dioxide concentration in inhaled NO patients was 1.5 ppm. Conclusions From this placebo-controlled study, inhaled NO appears to be well tolerated in the population of ARDS patients studied. With mechanical ventilation held constant, inhaled NO is associated with a significant improvement in oxygenation compared with placebo over the first 4 hrs of treatment. An improvement in oxygenation index was observed over the first 4 days. Larger phase III studies are needed to ascertain if these acute physiologic improvements can lead to altered clinical outcome.