University of Missouri

About: University of Missouri is a education organization based out in Columbia, Missouri, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 41427 authors who have published 83598 publications receiving 2911437 citations. The organization is also known as: Mizzou & Missouri-Columbia.

Immune mechanisms at the maternal-fetal interface: perspectives and challenges

Abstract: Leaders gathered at the US National Institutes of Health in November 2014 to discuss recent advances and emerging research areas in aspects of maternal-fetal immunity that may affect fetal development and pregnancy success.

Bayes factor approaches for testing interval null hypotheses

Abstract: Psychological theories are statements of constraint. The role of hypothesis testing in psychology is to test whether specific theoretical constraints hold in data. Bayesian statistics is well suited to the task of finding supporting evidence for constraint, because it allows for comparing evidence for 2 hypotheses against each another. One issue in hypothesis testing is that constraints may hold only approximately rather than exactly, and the reason for small deviations may be trivial or uninteresting. In the large-sample limit, these uninteresting, small deviations lead to the rejection of a useful constraint. In this article, we develop several Bayes factor 1-sample tests for the assessment of approximate equality and ordinal constraints. In these tests, the null hypothesis covers a small interval of non-0 but negligible effect sizes around 0. These Bayes factors are alternatives to previously developed Bayes factors, which do not allow for interval null hypotheses, and may especially prove useful to researchers who use statistical equivalence testing. To facilitate adoption of these Bayes factor tests, we provide easy-to-use software.

A chromosome bin map of 16,000 expressed sequence tag loci and distribution of genes among the three genomes of polyploid wheat.

Abstract: Because of the huge size of the common wheat (Triticum aestivum L., 2n = 6x = 42, AABBDD) genome of 17,300 Mb, sequencing and mapping of the expressed portion is a logical first step for gene discovery. Here we report mapping of 7104 expressed sequence tag (EST) unigenes by Southern hybridization into a chromosome bin map using a set of wheat aneuploids and deletion stocks. Each EST detected a mean of 4.8 restriction fragments and 2.8 loci. More loci were mapped in the B genome (5774) than in the A (5173) or D (5146) genomes. The EST density was significantly higher for the D genome than for the A or B. In general, EST density increased relative to the physical distance from the centromere. The majority of EST-dense regions are in the distal parts of chromosomes. Most of the agronomically important genes are located in EST-dense regions. The chromosome bin map of ESTs is a unique resource for SNP analysis, comparative mapping, structural and functional analysis, and polyploid evolution, as well as providing a framework for constructing a sequence-ready, BAC-contig map of the wheat genome.

Identification of a Plant Receptor for Extracellular ATP

Abstract: Extracellular adenosine 5′-triphosphate (ATP) is an essential signaling molecule that is perceived in mammals by plasma membrane P2-type purinoceptors Similar ATP receptors do not exist in plants, although extracellular ATP has been shown to play critical roles in plant growth, development, and stress responses Here, we identify an ATP-insensitive Arabidopsis mutant, dorn1 (Does not Respond to Nucleotides 1), defective in lectin receptor kinase I9 (Arabidopsis Information Resource accession code At5g60300) DORN1 binds ATP with high affinity (dissociation constant of 457 ± 31 nanomolar) and is required for ATP-induced calcium response, mitogen-activated protein kinase activation, and gene expression Ectopic expression of DORN1 increased the plant response to physical wounding We propose that DORN1 is essential for perception of extracellular ATP and likely plays a variety of roles in plant stress resistance