University of Missouri

About: University of Missouri is a education organization based out in Columbia, Missouri, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 41427 authors who have published 83598 publications receiving 2911437 citations. The organization is also known as: Mizzou & Missouri-Columbia.

Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis

Abstract: Previously, identification of promoters regulated by mammalian transcription factors has relied upon overexpression studies. Here we present the identification of a large set of promoters that are bound by E2F in physiological conditions. Probing a human CpG microarray with chromatin immunoprecipitated using an antibody to E2F4, we have identified 68 unique target loci; 15% are bidirectional promoters and 25% recruit E2F via a mechanism distinct from the defined consensus site. Interestingly, although E2F has been shown previously to regulate genes involved in cell cycle progression, many of the new E2F target genes encode proteins involved in DNA repair or recombination. We suggest that human CpG microarrays, in combination with chromatin immunoprecipitation, will allow rapid identification of target promoters for many mammalian transcription factors.

Source Localization Using TDOA and FDOA Measurements in the Presence of Receiver Location Errors: Analysis and Solution

Abstract: The accuracy of a source location estimate is very sensitive to the accurate knowledge of receiver locations. This paper performs analysis and develops a solution for locating a moving source using time-difference-of-arrival (TDOA) and frequency-difference-of-arrival (FDOA) measurements in the presence of random errors in receiver locations. The analysis starts with the Crameacuter-Rao lower bound (CRLB) for the problem, and derives the increase in mean-square error (MSE) in source location estimate if the receiver locations are assumed correct but in fact have error. A solution is then proposed that takes the receiver error into account to reduce the estimation error, and it is shown analytically, under some mild approximations, to achieve the CRLB accuracy for far-field sources. The proposed solution is closed form, computationally efficient, and does not have divergence problem as in iterative techniques. Simulations corroborate the theoretical results and the good performance of the proposed method

Impact of corporate insider, blockholder, and institutional equity ownership on firm risk taking

Abstract: The nature of a firm's risk-taking behavior can significantly affect corporate performance. In an agency context, we examined the influence of equity ownership structure upon corporate risk taking....

The integrity of independent variables in behavior analysis.

Abstract: Establishing a functional relationship between the independent and the dependent variable is the primary focus of applied behavior analysis. Accurate and reliable description and observation of both the independent and dependent variables are necessary to achieve this goal. Although considerable attention has been focused on ensuring the integrity of the dependent variable in the operant literature, similar effort has not been directed at ensuring the integrity of the independent variable. Inaccurate descriptions of the application of the independent variable may threaten the reliability and validity of operant research data. A survey of articles in the Journal of Applied Behavior Analysis demonstrated that the majority of articles published do not use any assessment of the actual occurrence of the independent variable and a sizable minority do not provide operational definitions of the independent variable. The feasibility and utility of ensuring the integrity of the independent variable is described.