University of Missouri

About: University of Missouri is a education organization based out in Columbia, Missouri, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 41427 authors who have published 83598 publications receiving 2911437 citations. The organization is also known as: Mizzou & Missouri-Columbia.

Analysis of Animal Space Use and Movements

Abstract: Publisher Summary Animal space use and movements are best understood through direct observation. This chapter describes a variety of techniques used to analyze animal space use, including home range estimation, analysis of site fidelity, and animal interactions. It also provides limitations of using many traditional techniques. The chapter provides a discussion of modeling animal movements using a combination of advanced descriptive and visualization approaches, general movement models, and biological models. The importance of sample size and autocorrelation of data in estimating home ranges and animal movements cannot be overemphasized. When considering tradeoffs between sample size and independence, obtaining an adequate sample size is more important than independence between data points. Any analysis of radiotelemetry data must consider the full range of biological and environmental factors that may impact the results. Home range estimation and animal movement analyses must answer difficult questions regarding the internal anatomy of home range boundaries and movement pathways through the judicious use of biological and environmental information. Also, radiotelemetry studies should go beyond simple, general descriptions and use a model-driven approach to examine the key factors determining why and how an animal uses space.

Role of Mitochondrial Dysfunction in Insulin Resistance

Abstract: Insulin resistance is characteristic of obesity, type 2 diabetes, and components of the cardiometabolic syndrome, including hypertension and dyslipidemia, that collectively contribute to a substantial risk for cardiovascular disease. Metabolic actions of insulin in classic insulin target tissues (eg, skeletal muscle, fat, and liver), as well as actions in nonclassic targets (eg, cardiovascular tissue), help to explain why insulin resistance and metabolic dysregulation are central in the pathogenesis of the cardiometabolic syndrome and cardiovascular disease. Glucose and lipid metabolism are largely dependent on mitochondria to generate energy in cells. Thereby, when nutrient oxidation is inefficient, the ratio of ATP production/oxygen consumption is low, leading to an increased production of superoxide anions. Reactive oxygen species formation may have maladaptive consequences that increase the rate of mutagenesis and stimulate proinflammatory processes. In addition to reactive oxygen species formation, genetic factors, aging, and reduced mitochondrial biogenesis all contribute to mitochondrial dysfunction. These factors also contribute to insulin resistance in classic and nonclassic insulin target tissues. Insulin resistance emanating from mitochondrial dysfunction may contribute to metabolic and cardiovascular abnormalities and subsequent increases in cardiovascular disease. Furthermore, interventions that improve mitochondrial function also improve insulin resistance. Collectively, these observations suggest that mitochondrial dysfunction may be a central cause of insulin resistance and associated complications. In this review, we discuss mechanisms of mitochondrial dysfunction related to the pathophysiology of insulin resistance in classic insulin-responsive tissue, as well as cardiovascular tissue.

Endocrine-Disrupting Chemicals and Public Health Protection: A Statement of Principles from The Endocrine Society

Abstract: An endocrine-disrupting chemical (EDC) is an exogenous chemical, or mixture of chemicals, that can interfere with any aspect of hormone action. The potential for deleterious effects of EDC must be considered relative to the regulation of hormone synthesis, secretion, and actions and the variability in regulation of these events across the life cycle. The developmental age at which EDC exposures occur is a critical consideration in understanding their effects. Because endocrine systems exhibit tissue-, cell-, and receptor-specific actions during the life cycle, EDC can produce complex, mosaic effects. This complexity causes difficulty when a static approach to toxicity through endocrine mechanisms driven by rigid guidelines is used to identify EDC and manage risk to human and wildlife populations. We propose that principles taken from fundamental endocrinology be employed to identify EDC and manage their risk to exposed populations. We emphasize the importance of developmental stage and, in particular, the realization that exposure to a presumptive “safe” dose of chemical may impact a life stage when there is normally no endogenous hormone exposure, thereby underscoring the potential for very low-dose EDC exposures to have potent and irreversible effects. Finally, with regard to the current program designed to detect putative EDC, namely, the Endocrine Disruptor Screening Program, we offer recommendations for strengthening this program through the incorporation of basic endocrine principles to promote further understanding of complex EDC effects, especially due to developmental exposures.

The Role of Gender Stereotypes in Perceptions of Entrepreneurs and Intentions to Become an Entrepreneur

Abstract: In this study we examine the role of socially constructed gender stereotypes in entrepreneurship and their influence on men and women's entrepreneurial intentions. Data on characteristics of males, females, and entrepreneurs were collected from young adults in three countries. As hypothesized, entrepreneurs were perceived to have predominantly masculine characteristics. Additional results revealed that although both men and women perceive entrepreneurs to have characteristics similar to those of males (masculine gender-role stereotype), only women also perceived entrepreneurs and females as having similar characteristics (feminine gender-role stereotype). Further, though men and women did not differ in their entrepreneurial intentions, those who perceived themselves as more similar to males (high on male gender identification) had higher entrepreneurial intentions than those who saw themselves as less similar to males (low male gender identification). No such difference was found for people who saw themselves as more or less similar to females (female gender identification). The results were consistent across the three countries. Practical implications and directions for future research are discussed.

The cocktail party phenomenon revisited: The importance of working memory capacity.

Abstract: Wood and Cowan (1995) replicated and extended Moray’s (1959) investigation of thecocktail party phenomenon, which refers to a situation in which one can attend to only part of a noisy environment, yet highly pertinent stimuli such as one’s own name can suddenly capture attention. Both of these previous investigations have shown that approximately 33% of subjects report hearing their own name in an unattended, irrelevant message. Here we show that subjects who detect their name in the irrelevant message have relatively low working-memory capacities, suggesting that they have difficulty blocking out, or inhibiting, distracting information.