University of Nebraska Omaha

About: University of Nebraska Omaha is a education organization based out in Omaha, Nebraska, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 4526 authors who have published 8905 publications receiving 213914 citations. The organization is also known as: UNO & University of Omaha.

Evaluation of Reinforcement Learning Control for Thermal Energy Storage Systems

Abstract: This paper describes a simulation-based investigation of machine-learning control for the supervisory control of building energy systems. Model-free reinforcement learning control is investigated for the operation of electrically driven cool thermal energy storage systems in commercial buildings. The reinforcement learning controller learns to charge and discharge a thermal storage tank based on the feedback it receives from past control actions. The learning agent interacts with its environment by commanding the thermal energy storage system and extracts cues about the environment solely based on the reinforcement feedback it receives, which in this study is the monetary cost of each control action. No prediction or system model is required. Over time and by exploring the environment, the reinforcement learning controller establishes a statistical summary of plant operation, which is continuously updated as operation continues. The controller learns to account for the time-dependent cost of electricity (...

HIV-1 neuropathogenesis: glial mechanisms revealed through substance abuse.

Abstract: Neuronal dysfunction and degeneration are ultimately responsible for the neurocognitive impairment and dementia manifest in neuroAIDS. Despite overt neuronal pathology, HIV-1 does not directly infect neurons; rather, neuronal dysfunction or death is largely an indirect consequence of disrupted glial function and the cellular and viral toxins released by infected glia. A role for glia in HIV-1 neuropathogenesis is revealed in experimental and clinical studies examining substance abuse-HIV-1 interactions. Current evidence suggests that glia are direct targets of substance abuse and that glia contribute markedly to the accelerated neurodegeneration seen with substance abuse in HIV-1 infected individuals. Moreover, maladaptive neuroplastic responses to chronic drug abuse might create a latent susceptibility to CNS disorders such as HIV-1. In this review, we consider astroglial and microglial interactions and dysfunction in the pathogenesis of HIV-1 infection and examine how drug actions in glia contribute to neuroAIDS.

Associations of disease activity and treatments with mortality in men with rheumatoid arthritis: results from the VARA registry

Abstract: Objectives. To examine the all-cause mortality rate and factors associated with mortality in US veteran men with RA. Methods. Men with RA were enrolled and followed until death or censoring. Vital status was ascertained through systematic record review and standardized mortality ratios (SMRs) were calculated using US life tables for men. Multivariate Cox proportional hazards regression was used to examine the independent associations of patient factors including socio-demographics, comorbidity, measures of RA disease activity/severity and medication use with mortality. Measures of RA disease activity and medications were examined as time-varying factors. Results. A total of 138 deaths were observed during 2314 patient-years of follow-up (n = 1015 patients), corresponding to a crude morality rate of 5.9 deaths per 100 patient-years (95% CI 5.0, 7.0) and an SMR of 2.1 (95% CI 1.8, 2.5). After multivariate adjustment, factors independently associated with higher mortality risk in men with RA included older age, Caucasian race, low body weight, an increased frequency of rheumatology visits, higher ESR and RF concentrations, increased DAS28, subcutaneous nodules and prednisone use. In contrast, MTX use [hazard ratio (HR) 0.63; 95% CI 0.42, 0.96] was associated with 40% lower mortality risk. Conclusion. Mortality rates among US male veterans with RA are more than twice those of age-matched men in the general population. These results suggest that optimizing disease control, particularly with regimens that include MTX and minimize glucocorticoid exposure, could improve long-term survival in this population.

Competitive intelligence and firm's performance in emerging markets: an exploratory study in India

Abstract: – This paper aims to explore the impact of competitive intelligence (CI) practices on the firm's performance in the emerging market context of India. The paper seeks to answer the following questions: do CI activities have an impact on the market performance of Indian firms? If so, what are the macro and micro environmental drivers of CI for Indian firms? How are CI activities organized within Indian firms? How is the usage and dissemination of CI taking place within Indian firms?, – The study used a stratified sample developed from a variety of mailing lists focusing on Indian firms. The study employed a cross‐sectional, survey‐based methodology., – The study identifies two key aspects: Indian firms that exhibit higher levels of CI activities indeed achieve better financial performance results; and the current level of CI activities in Indian firms is at a moderate level, thereby suggesting an opportunity for using and implementing more sophisticated CI techniques., – The findings of this study should assist local and foreign managers in having a more informed understanding of CI activities in the Indian marketplace. Additionally, these findings provide directives to managers regarding the untapped opportunities and potential that CI can offer in a highly volatile and rapidly changing market scenario., – This is the first study that empirically investigates the relationship between the level of CI activities and firm performance in an emerging market context. It is also the first study of its kind that explores the current state of CI practices in the Indian market.

Endurance training and performance in runners: research limitations and unanswered questions.

Abstract: The purpose of this review is to discuss several limitations common to research concerning running and, secondly, to identify selected areas where additional research appears needed. Hopefully, this review will provide guidance for future research in terms of topics, as well as design and methodology. Limitations in the research include: lack of longitudinal studies, inadequate description of training status of individuals, lack of confirmation of state of rest, nourishment and hydration, infrequent use of allometric scaling to express oxygen uptake, relative neglect of anaerobic power and physical structure as determinants of performance, neglect of the central nervous system, and reliance on laboratory data. Further research in a number of areas is needed to enhance our knowledge of running performance. This includes: body mass as a performance determinant, evaluation of methods used to measure economy of running, assessing the link between strength and running performance, and further examination of training methods. While the amount of research on distance running is voluminous, the present state of knowledge is somewhat restricted by the limitations in research design and methodology identified here.