Institution
University of Vermont
Education•Burlington, Vermont, United States•
About: University of Vermont is a education organization based out in Burlington, Vermont, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 17592 authors who have published 38251 publications receiving 1609874 citations. The organization is also known as: UVM & University of Vermont and State Agricultural College.
Papers published on a yearly basis
Papers
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TL;DR: Lifetime victimization was examined in a primarily European American sample that comprised 557 lesbian/gay, 163 bisexual, and 525 heterosexual adults, and sexual orientation differences in sexual victimization were greater among men than among women.
Abstract: Lifetime victimization was examined in a primarily European American sample that comprised 557 lesbian/gay, 163 bisexual, and 525 heterosexual adults. Lesbian, gay, and bisexual (LGB) participants were recruited via LGB e-mail lists, periodicals, and organizations; these participants recruited 1 or more siblings for participation in the study (81% heterosexual, 19% LGB). In hierarchical linear modeling analyses, sexual orientation was a significant predictor of most of the victimization variables. Compared with heterosexual participants, LGB participants reported more childhood psychological and physical abuse by parents or caretakers, more childhood sexual abuse, more partner psychological and physical victimization in adulthood, and more sexual assault experiences in adulthood. Sexual orientation differences in sexual victimization were greater among men than among women.
677 citations
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Memorial Sloan Kettering Cancer Center1, Harvard University2, Boston University3, University of Texas MD Anderson Cancer Center4, American Cancer Society5, Oregon Health & Science University6, University of Utah7, Kaiser Permanente8, University of Minnesota9, University of Colorado Denver10, University of Vermont11, University of Texas Southwestern Medical Center12, Creighton University13, Eastern Virginia Medical School14, Indiana University15
TL;DR: In this article, a careful analytic approach was designed to address all evidence available in the literature to delineate predictors of advanced pathology, both cancer and advanced adenomas, so that patients can be stratified more definitely at their baseline colonoscopy into those at lower risk or increased risk for a subsequent advanced neoplasia.
677 citations
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National Institutes of Health1, Johns Hopkins University2, University of Texas Medical Branch3, Centers for Disease Control and Prevention4, Creighton University5, United States Department of Agriculture6, Tufts University7, University of Virginia8, Brandeis University9, University of Vermont10, University of Maryland, Baltimore11, Christian Medical College & Hospital12, Veterans Health Administration13, Emory University14, University of Pennsylvania15, University of Georgia16, Murdoch University17, Tufts Medical Center18, University of Washington19, Texas A&M University20
TL;DR: Use of cryptosporidium genomes has helped to identify promising therapeutic targets, and drugs are in development, but methods to assess the efficacy in vitro and in animals are not well standardised.
Abstract: Summary Cryptosporidium spp are well recognised as causes of diarrhoeal disease during waterborne epidemics and in immunocompromised hosts. Studies have also drawn attention to an underestimated global burden and suggest major gaps in optimum diagnosis, treatment, and immunisation. Cryptosporidiosis is increasingly identified as an important cause of morbidity and mortality worldwide. Studies in low-resource settings and high-income countries have confirmed the importance of cryptosporidium as a cause of diarrhoea and childhood malnutrition. Diagnostic tests for cryptosporidium infection are suboptimum, necessitating specialised tests that are often insensitive. Antigen-detection and PCR improve sensitivity, and multiplexed antigen detection and molecular assays are underused. Therapy has some effect in healthy hosts and no proven efficacy in patients with AIDS. Use of cryptosporidium genomes has helped to identify promising therapeutic targets, and drugs are in development, but methods to assess the efficacy in vitro and in animals are not well standardised. Partial immunity after exposure suggests the potential for successful vaccines, and several are in development; however, surrogates of protection are not well defined. Improved methods for propagation and genetic manipulation of the organism would be significant advances.
676 citations
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TL;DR: Traditional cardiovascular risk factors had larger associations with cardiovascular mortality than novel risk factors in elderly persons with chronic kidney disease.
Abstract: ContextElderly persons with chronic kidney disease have substantial risk for
cardiovascular mortality, but the relative importance of traditional and novel
risk factors is unknown.ObjectiveTo compare traditional and novel risk factors as predictors of cardiovascular
mortality.Design, Setting, and PatientsA total of 5808 community-dwelling persons aged 65 years or older living
in 4 communities in the United States participated in the Cardiovascular Health
Study cohort. Participants were initially recruited from 1989 to June 1990;
an additional 687 black participants were recruited in 1992-1993. The average
length of follow-up in this longitudinal study was 8.6 years.Main Outcome MeasuresCardiovascular mortality among those with and without chronic kidney
disease. Chronic kidney disease was defined as an estimated glomerular filtration
rate of less than 60 mL/min per 1.73 m2.ResultsAmong the participants, 1249 (22%) had chronic kidney disease at baseline.
The cardiovascular mortality risk rate was 32 deaths/1000 person-years among
those with chronic kidney disease vs 16/1000 person-years among those without
it. In multivariate analyses, diabetes, systolic hypertension, smoking, low
physical activity, nonuse of alcohol, and left ventricular hypertrophy were
predictors of cardiovascular mortality in persons with chronic kidney disease
(all P values <.05). Among the novel risk factors,
only log C-reactive protein (P = .05) and
log interleukin 6 (P<.001) were associated with
the outcome as linear predictors. Traditional risk factors were associated
with the largest absolute increases in risks for cardiovascular deaths among
persons with chronic kidney disease: for left ventricular hypertrophy, there
were 25 deaths per 1000 person-years; current smoking, 20 per 1000 person-years;
physical inactivity, 15 per 1000 person-years; systolic hypertension, 14 per
1000 person-years; diabetes, 14 per 1000 person-years; and nonuse of alcohol,
11 per 1000 person-years vs 5 deaths per 1000 person-years for those with
increased C-reactive protein and 5 per 1000 person-years for those with increased
interleukin 6 levels. A receiver operating characteristic analysis found that
traditional risk factors had an area under the curve of 0.73 (95% confidence
interval, 0.70-0.77) among those with chronic kidney disease. Adding novel
risk factors only increased the area under the curve to 0.74 (95% confidence
interval, 0.71-0.78; P for difference = .15).ConclusionsTraditional cardiovascular risk factors had larger associations with
cardiovascular mortality than novel risk factors in elderly persons with chronic
kidney disease. Future research should investigate whether aggressive lifestyle
intervention in patients with chronic kidney disease can reduce their substantial
cardiovascular risk.
671 citations
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TL;DR: Findings further extend the association between intraneuronal aluminum and NFT formation and support the hypothesis that environmental factors are related to the neurodegenerative changes seen in the Chamorro population.
Abstract: Scanning electron microscopy with energy-dispersive x-ray spectrometry was used to analyze the elemental content of neurofibrillary tangle (NFT)-bearing and NFT-free neurons within the Sommer's sector (H1 region) of the hippocampus in Guamanian Chamorros with amyotrophic lateral sclerosis and parkinsonism-dementia and in neurologically normal controls. Preliminary data indicate prominent accumulation of aluminum within the nuclear region and perikaryal cytoplasm of NFT-bearing hippocampal neurons, regardless of the underlying neurological diagnosis. These findings further extend the association between intraneuronal aluminum and NFT formation and support the hypothesis that environmental factors are related to the neurodegenerative changes seen in the Chamorro population.
670 citations
Authors
Showing all 17727 results
Name | H-index | Papers | Citations |
---|---|---|---|
Albert Hofman | 267 | 2530 | 321405 |
Ralph B. D'Agostino | 226 | 1287 | 229636 |
George Davey Smith | 224 | 2540 | 248373 |
Stephen V. Faraone | 188 | 1427 | 140298 |
Valentin Fuster | 179 | 1462 | 185164 |
Dennis J. Selkoe | 177 | 607 | 145825 |
Anders Björklund | 165 | 769 | 84268 |
Alfred L. Goldberg | 156 | 474 | 88296 |
Christopher P. Cannon | 151 | 1118 | 108906 |
Debbie A Lawlor | 147 | 1114 | 101123 |
Roger J. Davis | 147 | 498 | 103478 |
Andrew S. Levey | 144 | 600 | 156845 |
Jonathan G. Seidman | 137 | 563 | 89782 |
Yu Huang | 136 | 1492 | 89209 |
Christine E. Seidman | 134 | 519 | 67895 |