Institution
University of Vermont
Education•Burlington, Vermont, United States•
About: University of Vermont is a education organization based out in Burlington, Vermont, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 17592 authors who have published 38251 publications receiving 1609874 citations. The organization is also known as: UVM & University of Vermont and State Agricultural College.
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King Mongkut's University of Technology Thonburi1, Ferdowsi University of Mashhad2, Xi'an Jiaotong University3, University of Monastir4, Shahid Beheshti University5, University of Rennes6, Clarkson University7, North Carolina State University8, University of Vermont9, University of New South Wales10, Khalifa University11, Royal Society12, King Abdulaziz University13, Quaid-i-Azam University14, University of Tehran15, Babeș-Bolyai University16
TL;DR: In this paper, the authors present a review of the main computational methods for solving the transport equations associated with nanofluid flow, including finite difference, finite volume, finite element, lattice Boltzmann methods, and Lagrangian methods.
433 citations
TL;DR: Different calcium signals in the endothelium and smooth muscle target different types of Ca2+-sensitive K+ channels to modulate vascular function and represent multilayered opportunities for prevention and/or treatment of vascular dysfunctions.
Abstract: Different calcium signals in the endothelium and smooth muscle target different types of Ca2+-sensitive K+ channels to modulate vascular function. These differential calcium signals and targets represent multilayered opportunities for prevention and/or treatment of vascular dysfunctions.
433 citations
TL;DR: The concept of "sense of place" typically is used to refer to an individual's ability to develop feelings of attachment to particular settings based on combinations of use, attentiveness, and emoti...
Abstract: The concept of “sense of place” typically is used to refer to an individual's ability to develop feelings of attachment to particular settings based on combinations of use, attentiveness, and emoti...
432 citations
TL;DR: It is concluded that TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels that elicits smooth muscle hyperpolarization and arterial dilation via Ca2-induced Ca1+ release in response to an endothelial-derived factor.
Abstract: Vasodilatory factors produced by the endothelium are critical for the maintenance of normal blood pressure and flow. We hypothesized that endothelial signals are transduced to underlying vascular smooth muscle by vanilloid transient receptor potential (TRPV) channels. TRPV4 message was detected in RNA from cerebral artery smooth muscle cells. In patch-clamp experiments using freshly isolated cerebral myocytes, outwardly rectifying whole-cell currents with properties consistent with those of expressed TRPV4 channels were evoked by the TRPV4 agonist 4alpha-phorbol 12,13-didecanoate (4alpha-PDD) (5 micromol/L) and the endothelium-derived arachidonic acid metabolite 11,12 epoxyeicosatrienoic acid (11,12 EET) (300 nmol/L). Using high-speed laser-scanning confocal microscopy, we found that 11,12 EET increased the frequency of unitary Ca2+ release events (Ca2+ sparks) via ryanodine receptors located on the sarcoplasmic reticulum of cerebral artery smooth muscle cells. EET-induced Ca2+ sparks activated nearby sarcolemmal large-conductance Ca2+-activated K+ (BKCa) channels, measured as an increase in the frequency of transient K+ currents (referred to as "spontaneous transient outward currents" [STOCs]). 11,12 EET-induced increases in Ca2+ spark and STOC frequency were inhibited by lowering external Ca2+ from 2 mmol/L to 10 micromol/L but not by voltage-dependent Ca2+ channel inhibitors, suggesting that these responses require extracellular Ca2+ influx via channels other than voltage-dependent Ca2+ channels. Antisense-mediated suppression of TRPV4 expression in intact cerebral arteries prevented 11,12 EET-induced smooth muscle hyperpolarization and vasodilation. Thus, we conclude that TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels that elicits smooth muscle hyperpolarization and arterial dilation via Ca2+-induced Ca2+ release in response to an endothelial-derived factor.
432 citations
University of California, San Diego1, McGill University2, Oregon Health & Science University3, Florida International University4, Yale University5, Washington University in St. Louis6, Virginia Commonwealth University7, University of Vermont8, University of Michigan9, Medical University of South Carolina10, National Institutes of Health11, SRI International12, University of Southern California13, McGovern Institute for Brain Research14, Harvard University15, Medical College of Wisconsin16, University of California, Irvine17, University of California, Los Angeles18, University of California, San Francisco19, University of Colorado Boulder20, University of Florida21, University of Maryland, Baltimore22, University of Massachusetts Boston23, University of Minnesota24, University of Pittsburgh25, University of Rochester26, University of Tennessee27, University of Utah28, University of Wisconsin–Milwaukee29, Boston University30, United States Department of Veterans Affairs31
TL;DR: The baseline neuroimaging processing and subject-level analysis methods used by the Adolescent Brain Cognitive Development Study are described to be a resource of unprecedented scale and depth for studying typical and atypical development.
431 citations
Authors
Showing all 17727 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Albert Hofman | 267 | 2530 | 321405 |
| Ralph B. D'Agostino | 226 | 1287 | 229636 |
| George Davey Smith | 224 | 2540 | 248373 |
| Stephen V. Faraone | 188 | 1427 | 140298 |
| Valentin Fuster | 179 | 1462 | 185164 |
| Dennis J. Selkoe | 177 | 607 | 145825 |
| Anders Björklund | 165 | 769 | 84268 |
| Alfred L. Goldberg | 156 | 474 | 88296 |
| Christopher P. Cannon | 151 | 1118 | 108906 |
| Debbie A Lawlor | 147 | 1114 | 101123 |
| Roger J. Davis | 147 | 498 | 103478 |
| Andrew S. Levey | 144 | 600 | 156845 |
| Jonathan G. Seidman | 137 | 563 | 89782 |
| Yu Huang | 136 | 1492 | 89209 |
| Christine E. Seidman | 134 | 519 | 67895 |