Institution
University of Vermont
Education•Burlington, Vermont, United States•
About: University of Vermont is a education organization based out in Burlington, Vermont, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 17592 authors who have published 38251 publications receiving 1609874 citations. The organization is also known as: UVM & University of Vermont and State Agricultural College.
Papers published on a yearly basis
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TL;DR: Recent treatment-outcome studies on voucher-based contingency management and community reinforcement therapy are reviewed demonstrating how reinforcement and related principles can be used to improve outcomes across a wide range of different substance use disorders and populations.
Abstract: Extensive scientific evidence indicates that reinforcement plays an important role in the genesis, maintenance, and recovery from substance use disorders. In this chapter, we review recent clinical research from laboratory, clinic, and naturalistic settings examining the role of reinforcement in substance use disorders. Well-controlled human laboratory studies are reviewed characterizing orderly interactions between the reinforcing effects of drugs and environmental context that have important implications for understanding risk factors for substance use disorders and for the development of efficacious interventions. Recent treatment-outcome studies on voucher-based contingency management and community reinforcement therapy are reviewed demonstrating how reinforcement and related principles can be used to improve outcomes across a wide range of different substance use disorders and populations. Overall, the chapter characterizes a vigorous area of clinical research that has much to contribute to a scientific analysis of substance use disorders.
334 citations
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TL;DR: An integrated set of worldviews, institutions, and technologies are suggested to stimulate and seed this evolutionary redesign of the current socio-ecological regime to achieve global sustainability.
Abstract: A high and sustainable quality of life is a central goal for humanity. Our current socio-ecological regime and its set of interconnected worldviews, institutions, and technologies all support the goal of unlimited growth of material production and consumption as a proxy for quality of life. However, abundant evidence shows that, beyond a certain threshold, further material growth no longer significantly contributes to improvement in quality of life. Not only does further material growth not meet humanity’s central goal, there is mounting evidence that it creates significant roadblocks to sustainability through increasing resource constraints (i.e., peak oil, water limitations) and sink constraints (i.e., climate disruption). Overcoming these roadblocks and creating a sustainable and desirable future will require an integrated, systems level redesign of our socio-ecological regime focused explicitly and directly on the goal of sustainable quality of life rather than the proxy of unlimited material growth. This transition, like all cultural transitions, will occur through an evolutionary process, but one that we, to a certain extent, can control and direct. We suggest an integrated set of worldviews, institutions, and technologies to stimulate and seed this evolutionary redesign of the current socio-ecological regime to achieve global sustainability. cultural adaptation ecology societal decline
334 citations
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TL;DR: This paper found that a strong market orientation helps facilitate a balance between incremental and radical innovation by shifting firms' innovation priority more toward radical innovation activities and also suggests that the abandonment of traditional conceptualizations and measures of market orientation are premature.
333 citations
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Agricultural Research Service1, University of Missouri2, National Institutes of Health3, Pacific Biosciences4, University of Adelaide5, Johns Hopkins University6, Livestock Improvement Corporation7, University of Maryland, College Park8, University of Vermont9, University of Idaho10, Institute for Animal Health11, University of Agriculture, Faisalabad12, University of Natural Resources and Life Sciences, Vienna13, Oklahoma State University–Stillwater14, University of California, Davis15
TL;DR: It is demonstrated that improved continuity of assembled sequence warrants the adoption of ARS-UCD1.2 as the new cattle reference genome and that increased assembly accuracy will benefit future research on this species.
Abstract: Author(s): Rosen, Benjamin D; Bickhart, Derek M; Schnabel, Robert D; Koren, Sergey; Elsik, Christine G; Tseng, Elizabeth; Rowan, Troy N; Low, Wai Y; Zimin, Aleksey; Couldrey, Christine; Hall, Richard; Li, Wenli; Rhie, Arang; Ghurye, Jay; McKay, Stephanie D; Thibaud-Nissen, Francoise; Hoffman, Jinna; Murdoch, Brenda M; Snelling, Warren M; McDaneld, Tara G; Hammond, John A; Schwartz, John C; Nandolo, Wilson; Hagen, Darren E; Dreischer, Christian; Schultheiss, Sebastian J; Schroeder, Steven G; Phillippy, Adam M; Cole, John B; Van Tassell, Curtis P; Liu, George; Smith, Timothy PL; Medrano, Juan F | Abstract: BackgroundMajor advances in selection progress for cattle have been made following the introduction of genomic tools over the past 10-12 years. These tools depend upon the Bos taurus reference genome (UMD3.1.1), which was created using now-outdated technologies and is hindered by a variety of deficiencies and inaccuracies.ResultsWe present the new reference genome for cattle, ARS-UCD1.2, based on the same animal as the original to facilitate transfer and interpretation of results obtained from the earlier version, but applying a combination of modern technologies in a de novo assembly to increase continuity, accuracy, and completeness. The assembly includes 2.7 Gb and is g250× more continuous than the original assembly, with contig N50 g25 Mb and L50 of 32. We also greatly expanded supporting RNA-based data for annotation that identifies 30,396 total genes (21,039 protein coding). The new reference assembly is accessible in annotated form for public use.ConclusionsWe demonstrate that improved continuity of assembled sequence warrants the adoption of ARS-UCD1.2 as the new cattle reference genome and that increased assembly accuracy will benefit future research on this species.
333 citations
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University of Toronto1, University of Haifa2, Pomeranian Medical University3, Creighton University4, University of Oslo5, Université de Montréal6, McGill University7, Erasmus University Rotterdam8, Tel Aviv University9, Sheba Medical Center10, University of British Columbia11, University of Western Ontario12, Princess Margaret Cancer Centre13, University of Pennsylvania14, Medical University of Vienna15, Harvard University16, Mayo Clinic17, Fox Chase Cancer Center18, Cincinnati Children's Hospital Medical Center19, Ohio State University20, Curie Institute21, Hamilton Health Sciences22, Clalit Health Services23, University of San Francisco24, Rambam Health Care Campus25, University of Chicago26, City of Hope National Medical Center27, Cedars-Sinai Medical Center28, University of Vermont29, University of Alberta30, University of Manitoba31, New York University32, York University33, University of Saskatchewan34, University of Texas MD Anderson Cancer Center35, University of Michigan36
TL;DR: Nearly one‐half of the women at risk for breast cancer had taken no preventive option, relying solely on screening, and there were large differences in the uptake of the different preventive options by country of residence.
Abstract: Several options for cancer prevention are available for women with a BRCA1 or BRCA2 mutation, including prophylactic surgery, chemoprevention and screening. The authors report on preventive practices in women with mutations from 9 countries and examine differences in uptake according to country. Women with a BRCA1 or BRCA2 mutation were contacted after receiving their genetic test result and were questioned regarding their preventive practices. Information was recorded on prophylactic mastectomy, prophylactic oophorectomy, use of tamoxifen and screening (MRI and mammography). Two thousand six hundred seventy-seven women with a BRCA1 or BRCA2 mutation from 9 countries were included. The follow-up questionnaire was completed a mean of 3.9 years (range 1.5-10.3 years) after genetic testing. One thousand five hundred thirty-one women (57.2%) had a bilateral prophylactic oophorectomy. Of the 1,383 women without breast cancer, 248 (18.0%) had had a prophylactic bilateral mastectomy. Among those who did not have a prophylactic mastectomy, only 76 women (5.5%) took tamoxifen and 40 women (2.9%) took raloxifene for breast cancer prevention. Approximately one-half of the women at risk for breast cancer had taken no preventive option, relying solely on screening. There were large differences in the uptake of the different preventive options by country of residence. Prophylactic oophorectomy is now generally accepted by women and their physicians as a cancer preventive measure. However, only the minority of women with a BRCA1 or BRCA2 mutation opt for prophylactic mastectomy or take tamoxifen for the prevention of hereditary breast cancer. Approximately one-half of women at risk for breast cancer rely on screening alone.
333 citations
Authors
Showing all 17727 results
Name | H-index | Papers | Citations |
---|---|---|---|
Albert Hofman | 267 | 2530 | 321405 |
Ralph B. D'Agostino | 226 | 1287 | 229636 |
George Davey Smith | 224 | 2540 | 248373 |
Stephen V. Faraone | 188 | 1427 | 140298 |
Valentin Fuster | 179 | 1462 | 185164 |
Dennis J. Selkoe | 177 | 607 | 145825 |
Anders Björklund | 165 | 769 | 84268 |
Alfred L. Goldberg | 156 | 474 | 88296 |
Christopher P. Cannon | 151 | 1118 | 108906 |
Debbie A Lawlor | 147 | 1114 | 101123 |
Roger J. Davis | 147 | 498 | 103478 |
Andrew S. Levey | 144 | 600 | 156845 |
Jonathan G. Seidman | 137 | 563 | 89782 |
Yu Huang | 136 | 1492 | 89209 |
Christine E. Seidman | 134 | 519 | 67895 |