Institution
University of Vermont
Education•Burlington, Vermont, United States•
About: University of Vermont is a education organization based out in Burlington, Vermont, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 17592 authors who have published 38251 publications receiving 1609874 citations. The organization is also known as: UVM & University of Vermont and State Agricultural College.
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TL;DR: These mice, engineered with a common genetic profile to human melanoma, provide a system to study melanoma's cardinal feature of metastasis and for preclinical evaluation of agents designed to prevent or treat metastatic disease.
Abstract: Mutational activation of BRAF is the earliest and most common genetic alteration in human melanoma. To build a model of human melanoma, we generated mice with conditional melanocyte-specific expression of BRaf(V600E). Upon induction of BRaf(V600E) expression, mice developed benign melanocytic hyperplasias that failed to progress to melanoma over 15-20 months. By contrast, expression of BRaf(V600E) combined with Pten tumor suppressor gene silencing elicited development of melanoma with 100% penetrance, short latency and with metastases observed in lymph nodes and lungs. Melanoma was prevented by inhibitors of mTorc1 (rapamycin) or MEK1/2 (PD325901) but, upon cessation of drug administration, mice developed melanoma, indicating the presence of long-lived melanoma-initiating cells in this system. Notably, combined treatment with rapamycin and PD325901 led to shrinkage of established melanomas. These mice, engineered with a common genetic profile to human melanoma, provide a system to study melanoma's cardinal feature of metastasis and for preclinical evaluation of agents designed to prevent or treat metastatic disease.
984 citations
University of British Columbia1, National Autonomous University of Mexico2, Arizona State University3, National University of Cordoba4, University of Oxford5, University of Vermont6, Helmholtz Centre for Environmental Research - UFZ7, Charles Sturt University8, Lüneburg University9, Oregon State University10, Georgia Institute of Technology11, University of Kiel12, Ikerbasque13, University of Victoria14
TL;DR: It is proposed that focusing only on instrumental or intrinsic values may fail to resonate with views on personal and collective well-being, or “what is right,” with regard to nature and the environment, and it is time to engage seriously with a third class of values, one with diverse roots and current expressions: relational values.
Abstract: A cornerstone of environmental policy is the debate over protecting nature for humans’ sake (instrumental values) or for nature’s (intrinsic values) (1). We propose that focusing only on instrumental or intrinsic values may fail to resonate with views on personal and collective well-being, or “what is right,” with regard to nature and the environment. Without complementary attention to other ways that value is expressed and realized by people, such a focus may inadvertently promote worldviews at odds with fair and desirable futures. It is time to engage seriously with a third class of values, one with diverse roots and current expressions: relational values. By doing so, we reframe the discussion about environmental protection, and open the door to new, potentially more productive policy approaches.
977 citations
Smithsonian Institution1, Sun Yat-sen University2, University of California, Berkeley3, Naturalis4, Paris-Sorbonne University5, Universidade Federal de Minas Gerais6, University of Vermont7, Federal University of Western Pará8, University of Florida9, James Cook University10, Duke University11, University of Bonn12, University of Neuchâtel13, University of Turku14, University of Alaska Fairbanks15, Missouri Botanical Garden16, National Taiwan University17, Museum of New Zealand Te Papa Tongarewa18, National University of Río Cuarto19, University of Arizona20, Council of Agriculture21, Kaohsiung Medical University22, Chongqing Normal University23, Universidade Federal de Juiz de Fora24, Nanjing Forestry University25, Iowa State University26, Complutense University of Madrid27, University of Kansas28, Denison University29, University of Zurich30
TL;DR: A modern, comprehensive classification for lycophytes and ferns, down to the genus level, utilizing a community‐based approach, that uses monophyly as the primary criterion for the recognition of taxa, but also aims to preserve existing taxa and circumscriptions that are both widely accepted and consistent with the understanding of pteridophyte phylogeny.
Abstract: Phylogeny has long informed pteridophyte classification. As our ability to infer evolutionary trees has improved, classifications aimed at recognizing natural groups have become increasingly predic ...
971 citations
University of New South Wales1, Oregon State University2, Braunschweig University of Technology3, University of California, San Diego4, Norwegian University of Life Sciences5, University of Liverpool6, Max Planck Society7, University of Tasmania8, University of Vermont9, ETH Zurich10, Stazione Zoologica Anton Dohrn11, Montana State University12, University of Amsterdam13, University of Southern California14, Pacific Northwest National Laboratory15, University of Hawaii at Manoa16, University of California, Berkeley17, Marine Biological Laboratory18, University of California, Irvine19, University of Georgia20, California Institute of Technology21, University of Edinburgh22, Ohio State University23, University of Sydney24, University of Alberta25, Georgia Institute of Technology26, Australian Institute of Marine Science27, University of Melbourne28, University of Texas Medical Branch29, University of Queensland30
TL;DR: This Consensus Statement documents the central role and global importance of microorganisms in climate change biology and puts humanity on notice that the impact of climate change will depend heavily on responses of micro organisms, which are essential for achieving an environmentally sustainable future.
Abstract: In the Anthropocene, in which we now live, climate change is impacting most life on Earth. Microorganisms support the existence of all higher trophic life forms. To understand how humans and other life forms on Earth (including those we are yet to discover) can withstand anthropogenic climate change, it is vital to incorporate knowledge of the microbial 'unseen majority'. We must learn not just how microorganisms affect climate change (including production and consumption of greenhouse gases) but also how they will be affected by climate change and other human activities. This Consensus Statement documents the central role and global importance of microorganisms in climate change biology. It also puts humanity on notice that the impact of climate change will depend heavily on responses of microorganisms, which are essential for achieving an environmentally sustainable future.
963 citations
University of Minnesota1, Norwegian School of Sport Sciences2, University of Vermont3, Naval Medical Center Portsmouth4, Duke University5, Hospital for Special Surgery6, Cincinnati Children's Hospital Medical Center7, Vanderbilt University8, University of Pittsburgh9, American Orthopaedic Society for Sports Medicine10, University of Toronto11, University of North Carolina at Chapel Hill12, University of Southern California13, University of North Carolina at Greensboro14, University of Washington15, University of Michigan16
TL;DR: A group of physicians, physical therapists, athletic trainers, biomechanists, epidemiologists, and other scientists interested in this area of research met to review current knowledge on risk factors associated with noncontact anterior cruciate ligament injuries.
Abstract: The incidence of noncontact anterior cruciate ligament injuries in young to middle-aged athletes remains high. Despite early diagnosis and appropriate operative and nonoperative treatments, posttraumatic degenerative arthritis may develop. In a meeting in Atlanta, Georgia (January 2005), sponsored by the American Orthopaedic Society for Sports Medicine, a group of physicians, physical therapists, athletic trainers, biomechanists, epidemiologists, and other scientists interested in this area of research met to review current knowledge on risk factors associated with noncontact anterior cruciate ligament injuries, anterior cruciate ligament injury biomechanics, and existing anterior cruciate ligament prevention programs. This article reports on the presentations, discussions, and recommendations of this group.
945 citations
Authors
Showing all 17727 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Albert Hofman | 267 | 2530 | 321405 |
| Ralph B. D'Agostino | 226 | 1287 | 229636 |
| George Davey Smith | 224 | 2540 | 248373 |
| Stephen V. Faraone | 188 | 1427 | 140298 |
| Valentin Fuster | 179 | 1462 | 185164 |
| Dennis J. Selkoe | 177 | 607 | 145825 |
| Anders Björklund | 165 | 769 | 84268 |
| Alfred L. Goldberg | 156 | 474 | 88296 |
| Christopher P. Cannon | 151 | 1118 | 108906 |
| Debbie A Lawlor | 147 | 1114 | 101123 |
| Roger J. Davis | 147 | 498 | 103478 |
| Andrew S. Levey | 144 | 600 | 156845 |
| Jonathan G. Seidman | 137 | 563 | 89782 |
| Yu Huang | 136 | 1492 | 89209 |
| Christine E. Seidman | 134 | 519 | 67895 |