University of Virginia

About: University of Virginia is a education organization based out in Charlottesville, Virginia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 52543 authors who have published 113268 publications receiving 5220506 citations. The organization is also known as: U of V & UVa.

The 2MASS Redshift Survey: description and data release

Abstract: We present the results of the 2MASS Redshift Survey (2MRS), a ten-year project to map the full three-dimensional distribution of galaxies in the nearby universe. The Two Micron All Sky Survey (2MASS) was completed in 2003 and its final data products, including an extended source catalog (XSC), are available online. The 2MASS XSC contains nearly a million galaxies with K_s ≤ 13.5 mag and is essentially complete and mostly unaffected by interstellar extinction and stellar confusion down to a galactic latitude of |b| = 5° for bright galaxies. Near-infrared wavelengths are sensitive to the old stellar populations that dominate galaxy masses, making 2MASS an excellent starting point to study the distribution of matter in the nearby universe. We selected a sample of 44,599 2MASS galaxies with K_s ≤ 11.75 mag and |b| ≥ 5° (≥8° toward the Galactic bulge) as the input catalog for our survey. We obtained spectroscopic observations for 11,000 galaxies and used previously obtained velocities for the remainder of the sample to generate a redshift catalog that is 97.6% complete to well-defined limits and covers 91% of the sky. This provides an unprecedented census of galaxy (baryonic mass) concentrations within 300 Mpc. Earlier versions of our survey have been used in a number of publications that have studied the bulk motion of the Local Group, mapped the density and peculiar velocity fields out to 50 h^(–1) Mpc, detected galaxy groups, and estimated the values of several cosmological parameters. Additionally, we present morphological types for a nearly complete sub-sample of 20,860 galaxies with K_s ≤ 11.25 mag and |b| ≥ 10°.

Observation of a new boson with mass near 125 GeV in pp collisions at $ \sqrt{s}=7 $ and 8 TeV

Abstract: A detailed description is reported of the analysis used by the CMS Collaboration in the search for the standard model Higgs boson in pp collisions at the LHC, which led to the observation of a new boson. The data sample corresponds to integrated luminosities up to 5.1 inverse femtobarns at sqrt(s) = 7 TeV, and up to 5.3 inverse femtobarns at sqrt(s) = 8 TeV. The results for five Higgs boson decay modes gamma gamma, ZZ, WW, tau tau, and bb, which show a combined local significance of 5 standard deviations near 125 GeV, are reviewed. A fit to the invariant mass of the two high resolution channels, gamma gamma and ZZ to 4 ell, gives a mass estimate of 125.3 +/- 0.4 (stat) +/- 0.5 (syst) GeV. The measurements are interpreted in the context of the standard model Lagrangian for the scalar Higgs field interacting with fermions and vector bosons. The measured values of the corresponding couplings are compared to the standard model predictions. The hypothesis of custodial symmetry is tested through the measurement of the ratio of the couplings to the W and Z bosons. All the results are consistent, within their uncertainties, with the expectations for a standard model Higgs boson.

Feedback Control Real-Time Scheduling: Framework, Modeling, and Algorithms*

Abstract: We develop Feedback Control real-time Scheduling (FCS) as a unified framework to provide Quality of Service (QoS) guarantees in unpredictable environments (such as e-business servers on the Internet). FCS includes four major components. First, novel scheduling architectures provide performance control to a new category of QoS critical systems that cannot be addressed by traditional open loop scheduling paradigms. Second, we derive dynamic models for computing systems for the purpose of performance control. These models provide a theoretical foundation for adaptive performance control. Third, we apply established control methodology to design scheduling algorithms with proven performance guarantees, which is in contrast with existing heuristics-based solutions relying on laborious design/tuning/testing iterations. Fourth, a set of control-based performance specifications characterizes the efficiency, accuracy, and robustness of QoS guarantees. The generality and strength of FCS are demonstrated by its instantiations in three important applications with significantly different characteristics. First, we develop real-time CPU scheduling algorithms that guarantees low deadline miss ratios in systems where task execution times may deviate from estimations at run-time. We solve the saturation problems of real-time CPU scheduling systems with a novel integrated control structure. Second, we develop an adaptive web server architecture to provide relative and absolute delay guarantees to different service classes with unpredictable workloads. The adaptive architecture has been implemented by modifying an Apache web server. Evaluation experiments on a testbed of networked Linux PC's demonstrate that our server provides robust relative/absolute delay guarantees despite of instantaneous changes in the user population. Third, we develop a data migration executor for networked storage systems that migrate data on-line while guaranteeing specified I/O throughput of concurrent applications.

The impact of pretend play on children's development: a review of the evidence.

Abstract: Pretend play has been claimed to be crucial to children’s healthy development. Here we examine evidence for this position versus 2 alternatives: Pretend play is 1 of many routes to positive developments (equifinality), and pretend play is an epiphenomenon of other factors that drive development. Evidence from several domains is considered. For language, narrative, and emotion regulation, the research conducted to date is consistent with all 3 positions but insufficient to draw conclusions. For executive function and social skills, existing research leans against the crucial causal position but is insufficient to differentiate the other 2. For reasoning, equifinality is definitely supported, ruling out a crucially causal position but still leaving open the possibility that pretend play is epiphenomenal. For problem solving, there is no compelling evidence that pretend play helps or is even a correlate. For creativity, intelligence, conservation, and theory of mind, inconsistent correlational results from sound studies and nonreplication with masked experimenters are problematic for a causal position, and some good studies favor an epiphenomenon position in which child, adult, and environment characteristics that go along with play are the true causal agents. We end by considering epiphenomenalism more deeply and discussing implications for preschool settings and further research in this domain. Our take-away message is that existing evidence does not support strong causal claims about the unique importance of pretend play for development and that much more and better research is essential for clarifying its possible role.

Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae

Abstract: Histone methylation is known to be associated with both transcriptionally active and repressive chromatin states. Recent studies have identified SET domain–containing proteins such as SUV39H1 and Clr4 as mediators of H3 lysine 9 (Lys9) methylation and heterochromatin formation. Interestingly, H3 Lys9 methylation is not observed from bulk histones isolated from asynchronous populations of Saccharomyces cerevisiae or Tetrahymena thermophila. In contrast, H3 lysine 4 (Lys4) methylation is a predominant modification in these smaller eukaryotes. To identify the responsible methyltransferase(s) and to gain insight into the function of H3 Lys4 methylation, we have developed a histone H3 Lys4 methyl-specific antiserum. With this antiserum, we show that deletion of SET1, but not of other putative SET domain–containing genes, in S. cerevisiae, results in the complete abolishment of H3 Lys4 methylation in vivo. Furthermore, loss of H3 Lys4 methylation in a set1Δ strain can be rescued by SET1. Analysis of histone H3 mutations at Lys4 revealed a slow-growth defect similar to a set1Δ strain. Chromatin immunoprecipitation assays show that H3 Lys4 methylation is present at the rDNA locus and that Set1-mediated H3 Lys4 methylation is required for repression of RNA polymerase II transcription within rDNA. Taken together, these data suggest that Set1-mediated H3 Lys4 methylation is required for normal cell growth and transcriptional silencing.